Nawal Kinany
A5082328309- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Medical Imaging and Analysis
- Transcranial Magnetic Stimulation Studies
- Spinal Cord Injury Research
- Motor Control and Adaptation
- Prosthetics and Rehabilitation Robotics
- Action Observation and Synchronization
- Balance, Gait, and Falls Prevention
- Acute Ischemic Stroke Management
- Spine and Intervertebral Disc Pathology
- Virtual Reality Applications and Impacts
- Neural dynamics and brain function
- Spinal Dysraphism and Malformations
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neural Engineering
- Heart Rate Variability and Autonomic Control
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Brain Tumor Detection and Classification
- Cervical and Thoracic Myelopathy
École Polytechnique Fédérale de Lausanne
2017-2025
University of Geneva
2018-2025
Charles Humbert 8
2022
Wyss Center for Bio and Neuroengineering
2019-2022
Bioengineering Center
2019
Imperial College London
2016-2017
Abstract The lumbosacral spinal cord contains neural circuits crucial for locomotion, organized into rostrocaudal levels with distinct somatosensory and motor neuron pools that project to from the muscles of lower limbs. However, specific innervate each muscle locations vary significantly between individuals, presenting challenges targeted therapies neurosurgical interventions aimed at restoring locomotion. Non-invasive approaches functionally map segmental distribution innervation – or...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
Functional magnetic resonance imaging (fMRI) has revolutionized the investigation of brain function. Similar approaches can be translated to probe spinal mechanisms. However, cord remains challenging, notably due its size and location. Technological advances are gradually tackling these issues, though there is yet no consensus on optimal acquisition protocols. In this study, we assessed performance three sequences during a simple motor task at rest, in 15 healthy humans. Building upon recent...
Multiplayer video games promoting exercise-based rehabilitation may facilitate motor learning, by increasing motivation through social interaction. However, a major design challenge is to enable meaningful inter-subject interaction, whilst allowing for significant skill differences between players. We present novel motor-training paradigm that allows real-time collaboration and performance enhancement, across wide range of mismatches, including disabled vs. able-bodied partnerships.A virtual...
Several training programs have been developed in the past to restore motor functions after stroke. Their efficacy strongly relies on possibility assess individual levels of impairment and recovery rate. However, commonly used clinical scales rely mainly subjective functional assessments are not able provide a complete description patients' neuro-biomechanical status. Therefore, current tests should be integrated with specific physiological measurements, i.e. kinematic, muscular, brain...
Abstract Functional magnetic resonance imaging (fMRI) of the spinal cord is relevant for studying sensation, movement, and autonomic function. Preprocessing fMRI data involves segmentation on gradient-echo echo planar (EPI) images. Current automated methods do not work well these data, due to low spatial resolution, susceptibility artifacts causing distortions signal drop-out, ghosting, motion-related artifacts. Consequently, this task demands a considerable amount manual effort which takes...
Abstract Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources biological variation such as subject’s sex age. However, corrections body size (i.e. height weight) are mostly lacking in clinical neuroimaging designs. This investigates importance parameters their relationship with spinal cord (SC) brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population...
Mapping the neural patterns that drive human behavior is a key challenge in neuroscience. Even simplest of our everyday actions stem from dynamic and complex interplay multiple structures across central nervous system (CNS). Yet, most neuroimaging research has focused on investigating cerebral mechanisms, while way spinal cord accompanies brain shaping been largely overlooked. Although recent advent functional magnetic resonance imaging (fMRI) sequences can simultaneously target opened up...
Functional magnetic resonance imaging (fMRI) has been widely employed to study stroke pathophysiology. In particular, analyses of fMRI signals at rest were directed quantifying the impact on spatial features brain networks. However, networks have intrinsic time that were, so far, disregarded in these analyses. consequence, standard analysis failed capture temporal imbalance resulting from lesions, hence restricting their ability reveal interdependent pathological changes structural and...
Abstract Somatotopy, the topographical arrangement of sensorimotor pathways corresponding to distinct body parts, is a fundamental feature human central nervous system (CNS). Traditionally, investigations into brain and spinal cord somatotopy have been conducted independently, primarily utilizing stimulations or movements. To date, however, no study has probed somatotopic cerebro-spinal functional connections in vivo humans. In this study, we used simultaneous cervical magnetic resonance...
Abstract Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources biological variation such as subject’s sex age. However, corrections body size (i.e. height weight) are mostly lacking in clinical neuroimaging designs. This investigates importance parameters their relationship with spinal cord (SC) brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population...
Abstract Background In the past years, robotic systems have become increasingly popular in upper limb rehabilitation. Nevertheless, clinical studies so far not been able to confirm superior efficacy of therapy over conventional methods. The personalization robot-aided according patients’ individual motor deficits has suggested as a pivotal step improve outcome such approaches. Methods Here, we present model-based approach personalize rehabilitation within training sessions. proposed method...
Abstract The spinal cord is a critical component of the central nervous system, transmitting and integrating signals between brain periphery via topographically organized functional levels. Despite its role in sensorimotor processes several neuromotor disorders, mapping organization vivo humans has been long-standing challenge. Here, we test efficacy two data-driven connectivity approaches to produce reliable temporally stable parcellation cervical through resting-state networks different...
In recent years, while the exploration of spontaneous brain activity has shifted from static methods (i.e., examining average connectivity patterns over entire run) towards dynamic approaches accounting for non-stationarity resting-state fluctuations), non-stationary nature intrinsic in spinal cord seldom been studied. Here, we propose to probe time-varying functional using a sliding-window correlation approach, as commonly employed brain. Our results suggest potential this approach unravel...
Abstract In the past decade, exploration of spontaneous blood-oxygen-level-dependent (BOLD) signal fluctuations has expanded beyond brain to include spinal cord. While most studies have predominantly focused on cervical region, lumbosacral segments play a crucial role in motor control and sensory processing lower limbs. Addressing this gap, aims current study were twofold: first, confirming presence nature organized BOLD signals human cord; second, systematically assessing impact various...
Abstract Somatotopy, the topographical arrangement of sensorimotor pathways corresponding to distinct body parts, is a fundamental feature human central nervous system (CNS). Traditionally, investigations into brain and spinal cord somatotopy have been conducted independently, primarily utilizing stimulations or movements. To date, however, no study has probed somatotopic cerebro-spinal functional connections in vivo humans. In this study, we used simultaneous cervical magnetic resonance...