A5027926308- Spinal Cord Injury Research
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Anesthesia and Neurotoxicity Research
- Social Policies and Family
- Photoreceptor and optogenetics research
- Pain Management and Treatment
- Memory and Neural Mechanisms
- Cardiac Arrest and Resuscitation
- Neurogenesis and neuroplasticity mechanisms
- Technology and Human Factors in Education and Health
- Neuroscience of respiration and sleep
- Neural Networks and Applications
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Prosthetics and Rehabilitation Robotics
- Nerve Injury and Rehabilitation
- Cerebral Palsy and Movement Disorders
École Polytechnique Fédérale de Lausanne
2018-2025
University of Lausanne
2025
University of Copenhagen
2023-2024
Laboratoire d'Informatique Fondamentale de Lille
2022
University Hospital of Lausanne
2018
A spinal cord injury interrupts the communication between brain and region of that produces walking, leading to paralysis1,2. Here, we restored this with a digital bridge enabled an individual chronic tetraplegia stand walk naturally in community settings. This brain-spine interface (BSI) consists fully implanted recording stimulation systems establish direct link cortical signals3 analogue modulation epidural electrical targeting regions involved production walking4-6. highly reliable BSI...
Abstract A spinal cord injury interrupts pathways from the brain and brainstem that project to lumbar cord, leading paralysis. Here we show spatiotemporal epidural electrical stimulation (EES) of 1–3 applied during neurorehabilitation 4,5 (EES REHAB ) restored walking in nine individuals with chronic injury. This recovery involved a reduction neuronal activity humans walking. We hypothesized this unexpected reflects activity-dependent selection specific subpopulations become essential for...
Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. Here, we developed an implantable spinal cord neuroprosthesis operating in a closed loop robust walking and cycling assisted by robotic devices. This is device agnostic designed for seamless implementation nonexpert users. Preliminary...
Body weight support (BWS) systems are widely used in gait research and rehabilitation. This letter introduces a new three-dimensional overground BWS system, called the RYSEN. The RYSEN is designed to be intrinsically safe low power consuming, while still performing at least as well existing regarding human-robot interaction. These features mainly achieved by decoupling degrees of freedom between motors: slow/high-torque motors for vertical motion fast/low-torque horizontal motion. explains...
Abstract It is known that movement arrest can be induced by optogenetic stimulation of a brainstem nucleus, the pedunculopontine nucleus (PPN)1–6. This evoked appears conspicuously similar to freezing behavior often seen as fear response. Nevertheless, could also represent global halting mechanism for movement. introduces two possible roles this nucleus: A hub orchestrating fear-related responses or an omnipotent devoid emotional components could, in principle, encompass brain activities...
ABSTRACT Generation of locomotion is a fundamental function the spinal cord, yet underlying principles remain unclear. In particular, relationship between neuronal cell types, networks and has been difficult to establish 1, 2 . Here, we propose by which functions arise primarily from spatial features cord. First, suggest that distinct types with dissimilar length projection constitute an asymmetrical “Mexican hat” topology, i.e. local excitation surrounding inhibition, along rostro-caudal...
ABSTRACT Complete movement arrest has recently been reported to be induced in rodents by optogenetic stimulation of a subpopulation within the pedunculopontine nucleus (PPN). This evoked appears conspicuously similar freezing behavior often seen as fear response prey animals but could also akin gait, which is symptom Parkinson’s disease. introduces two perspectives on functional roles this sub-region: A hub for orchestrating fear-related responses or an omnipotent halting mechanism devoid...