A5010091221- Spinal Cord Injury Research
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Stroke Rehabilitation and Recovery
- Family and Disability Support Research
- Nerve Injury and Rehabilitation
- Breastfeeding Practices and Influences
- Injury Epidemiology and Prevention
- COVID-19 and Mental Health
- Neonatal Respiratory Health Research
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Pancreatic function and diabetes
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Exercise and Physiological Responses
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Issues in Pregnancy
- Metabolism, Diabetes, and Cancer
- Infant Development and Preterm Care
- Cardiovascular Effects of Exercise
- Sexual function and dysfunction studies
- Genetics and Neurodevelopmental Disorders
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
International Collaboration On Repair Discoveries
2016-2024
University of British Columbia
2016-2022
University of Lausanne
2022
École Polytechnique Fédérale de Lausanne
2018-2021
Wellcome/MRC Cambridge Stem Cell Institute
2017
Medical Research Council
2017
University of Cambridge
2017
Hutchison/MRC Research Centre
2017
University of Toronto
2016
GF Strong Rehabilitation Centre
2016
The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of Ngn3 protein is largely unexplored. Here we demonstrate that undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple serine-proline sites. Replacing wild-type with phosphomutant form increases α generation, the earliest type to be formed developing pancreas. Moreover, un(der)phosphorylated maintains insulin expression adult β...
Autonomic dysreflexia (AD), which describes episodic hypertension, is highly prevalent in people with spinal cord injury (SCI). In non-SCI, primary hypertension depresses cardiac contractile reserve via β-adrenergic mechanisms. this study, we investigated whether AD contributes to the impairment function that accompanies SCI. We induced SCI rodents and stratified them into sham, SCI, or plus repetitive induction of AD. At 6-week post-SCI, assessed using vivo (speckle-tracking...
Purpose: To (1) evaluate the level of agreement between individually calibrated accelerometers and self-reported Physical Activity Recall Assessment for People with Spinal Cord Injury when assessing moderate-vigorous physical activity; (2) qualitatively examine different components activity each measure assesses.Materials/methods: Nineteen manual wheelchair users chronic spinal cord injury (19.0 ± 12.9 years post injury, C5-L2 level) wore a wrist spoke accelerometer one week then returned to...
There are known sex differences in blood pressure regulation. The related to ovarian hormones that influence β-adrenergic receptors and the transduction of muscle sympathetic nerve activity. Oral contraceptives (OC) modulate hormonal profile women therefore may alter cardiovascular response. We questioned if OC would absolute pressor response static exercise day-to-day variability Healthy men (n = 11) 19) completed a familiarization day 2 experimental testing days. Women were divided into...
Electrical spinal cord neuromodulation has emerged as a leading intervention for restoring autonomic functions, such blood pressure, lower urinary tract (LUT), bowel, and sexual following injury (SCI). While few preliminary studies have shown the potential effect of non-invasive transcutaneous stimulation (tSCS) on recovery SCI, optimal parameters, well real-time long-term functional benefits tSCS are understudied. This trial entitled "Non-invasive Neuromodulation to Treat Bladder, Bowel,...
The World Health Organization (WHO) recommends that children be breastfed exclusively for the first 6 months of age. This recommendation may prove challenging women with spinal cord injury (SCI) who face unique challenges and barriers to breastfeeding due impact SCI on mobility physiology. Tailored provision care from health professionals (HCPs) is important in helping navigate these potential barriers. Yet, HCPs often lack confidence SCI-specific knowledge meet needs mothers SCI. An...
New Findings What is the central question of this study? How does early versus delayed initiation passive hindlimb cycling, as well detraining, affect cardiac function and blood pressure control in a rodent model spinal cord injury? main finding its importance? Early or cycling improves haemodynamic injury, although benefits administration are more pronounced. We also demonstrate need for exercise to be maintained, because detraining rapidly reverses benefits. Spinal injury (SCI) reduces...
ABSTRACT The World Health Organization (WHO) recommends that infants be breastfed exclusively for the first 6 months of age. However, there are few resources available on effects a spinal cord injury (SCI) can have breastfeeding mothers. It is difficult to find information address unique challenges women with SCI experience when planning or trying breastfeed. Our international team, including SCI, health care providers, and researchers, aims gap through creation this consumer guide. purpose...
Abstract We aimed to investigate the impact of postponement Tokyo 2020 Paralympic Games on expected participants’ careers, COVID-19 history and mental health using an e-survey. Thirty-nine participants (median age 37 years; 16 females) from five countries responded between July 20 th September 28 , 2021, which completed survey, including athletes 11 coaches. All but two planned attend rescheduled in 2021 (95%). Ninety percent (35/39) had previously tested at least once for COVID-19, with six...