A5042437588- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Telomeres, Telomerase, and Senescence
- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- Phagocytosis and Immune Regulation
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
- Virus-based gene therapy research
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
King's College London
2024-2025
The Francis Crick Institute
2023-2025
University of Cambridge
2015-2024
University of California, San Francisco
2008-2023
Cancer Research Institute
2001-2023
UCSF Helen Diller Family Comprehensive Cancer Center
2007-2017
Cold Spring Harbor Laboratory
2016
University of Turku
2013
Åbo Akademi University
2013
University of Helsinki
1989-2013
Six monoclonal antibodies have been isolated from mice immunized with synthetic peptide immunogens whose sequences are derived that of the human c-myc gene product. Five these precipitate p62c-myc cells, and three five also recognize mouse None sees chicken p110gag-myc protein. All six immunoblotted p62c-myc. These reagents provide basis for an immunoblotting assay by which to quantitate in cells.
Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-) were found be developmentally normal and reproductively fit failed develop any age-related disorders. when Bak-deficient mated Bax-deficient create both genes, the majority of bax(-/-)bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. displayed multiple developmental...
Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation. Whether autophagy observed cancer represents mechanism that allows to survive therapy for initiating nonapoptotic form of programmed cell death remains controversial. To address this issue, the role Myc-induced model lymphoma generated from derived p53ERTAM/p53ERTAM mice (with ER denoting estrogen receptor) was examined. Such tumors are resistant apoptosis due...
Journal Article A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins Get access Trevor D. Littlewood, Littlewood * Biochemistry Cell NucleusLondon WC2A 3PX, UK To whom correspondence should be addressed Search other works by this author on: Oxford Academic PubMed Google Scholar David C. Hancock, Hancock Paul S. Danielian, Danielian 1Molecular Endocrinology Laboratories, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln's...
Six monoclonal antibodies have been isolated from mice immunized with synthetic peptide immunogens whose sequences are derived that of the human c-myc gene product. Five these precipitate p62c-myc cells, and three five also recognize mouse None sees chicken p110gag-myc protein. All six immunoblotted p62c-myc. These reagents provide basis for an immunoblotting assay by which to quantitate in cells.
We studied death of human vascular smooth muscle cells derived from coronary plaques and normal arteries aorta. Cells underwent only upon removal serum growth factors. In contrast, plaque-derived died even in high conditions, increased after withdrawal. Death was characteristically by apoptosis both cells, as determined time-lapse videomicroscopy, electron microscopy, DNA fragmentation patterns. IGF-1 PDGF were identified potent survival factors serum, whereas EGF basic fibroblast factor had...
Caspase-3 is an effector of apoptosis in experimental models Parkinson's disease (PD). However, its potential role the human pathology remains to be demonstrated. Using caspase-3 immunohistochemistry on postmortem brain, we observed a positive correlation between degree neuronal loss dopaminergic (DA) cell groups affected mesencephalon PD patients and percentage caspase-3-positive neurons these control subjects significant decrease pigmented substantia nigra pars compacta compared with...