Achilleas Laskaratos
A5067121903- Single-cell and spatial transcriptomics
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Multiple Sclerosis Research Studies
- Chronic Lymphocytic Leukemia Research
- Zebrafish Biomedical Research Applications
- COVID-19 Clinical Research Studies
- Autoimmune Neurological Disorders and Treatments
- Sleep and Wakefulness Research
- Immune responses and vaccinations
- Osteoarthritis Treatment and Mechanisms
- Cardiac Arrest and Resuscitation
- RNA Research and Splicing
- Transcranial Magnetic Stimulation Studies
- Regulation of Appetite and Obesity
- Neonatal and fetal brain pathology
- Immune cells in cancer
- COVID-19 Impact on Reproduction
- Tissue Engineering and Regenerative Medicine
- Circadian rhythm and melatonin
- Nerve injury and regeneration
- Neurological disorders and treatments
École Polytechnique Fédérale de Lausanne
2021-2024
University of Lausanne
2023
National and Kapodistrian University of Athens
2020-2022
Singapore Bioimaging Consortium
2021
Agency for Science, Technology and Research
2021
University of Thessaly
2021
Eginition Hospital
2020
Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing identify that restore walking after incomplete SCI. We show chemoattracting guiding the transected...
Here, we introduce the Tabulae Paralytica —a compilation of four atlases spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas half million cells; multiome pairing transcriptomic and epigenomic measurements within same nuclei; two spatial injured spanning temporal dimensions. We integrated these into common framework to dissect molecular logic that governs responses cord. The exposed new biological principles dictate consequences SCI, including conserved divergent neuronal...
Autonomic dysreflexia is a life-threatening medical condition characterized by episodes of uncontrolled hypertension that occur in response to sensory stimuli after spinal cord injury (SCI) 1–7 . The fragmented understanding the mechanisms underlying autonomic hampers development therapeutic strategies manage this condition, leaving people with SCI at daily risk heart attack and stroke 8–18 Here, we expose complete de novo neuronal architecture develops causes dysreflexia. In parallel,...
We introduce Vespucci, a machine-learning method to identify perturbation-responsive regions, genes and gene programs within comparative spatial transcriptomics atlases. validate Vespucci on simulated published datasets show that it outperforms 19 computational methods for transcriptomics. apply expose the organization of activated by therapies guide repair injured spinal cord.
We studied whether progression of severe pneumonia into post-acute COVID-19 syndrome (PACS) is associated with long-term immune dysregulation. Patients known history during two different time periods and matched comparators were divided a discovery cohort (n=46, September-October 2020) validation (n=484, June-August 2021). Peripheral blood mononuclear cells (PBMCs) stimulated for cytokine production, patient-reported questionnaires lung function tests (LFTs) analyzed. Increased production...