A5014518827- Botulinum Toxin and Related Neurological Disorders
- Hematopoietic Stem Cell Transplantation
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Cerebrospinal fluid and hydrocephalus
- Pain Management and Treatment
- Fetal and Pediatric Neurological Disorders
- Neuroblastoma Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological disorders and treatments
- Single-cell and spatial transcriptomics
- Pharmacological Effects and Toxicity Studies
- Pain Mechanisms and Treatments
- Facial Nerve Paralysis Treatment and Research
- Neurogenesis and neuroplasticity mechanisms
- Myofascial pain diagnosis and treatment
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Spinal Dysraphism and Malformations
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical and Biological Ozone Research
- Blood transfusion and management
- Advanced Glycation End Products research
- Nerve injury and regeneration
- Scoliosis diagnosis and treatment
Hôpital Orthopédique de la Suisse Romande
2022-2025
École Polytechnique Fédérale de Lausanne
2023-2024
University of Lausanne
2021-2024
University Hospital of Lausanne
2017-2021
Bicêtre Hospital
2019
Assistance Publique – Hôpitaux de Paris
2019
Bambino Gesù Children's Hospital
2010-2011
University of Pavia
2011
University of Rome Tor Vergata
2007-2009
Università Cattolica del Sacro Cuore
1989-1990
Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing identify that restore walking after incomplete SCI. We show chemoattracting guiding the transected...
Background and objectives: The retrosigmoid approach (RSA) is considered the standard surgical choice to address a neurovascular conflict involving trigeminal nerve. subtemporal transtentorial (STA) represents main alternative. We describe here mini-invasive anterior petrosal intertentorial with view reduce complications associated STA. Methods: M-APIA was described for case of refractory neuralgia. This includes very limited amount drilling petrous ridge expose posterior fossa dura superior...
Hematopoietic stem cell transplantation is commonly used to treat several oncohematologic diseases. The autologous hematopoietic progenitor cells collected through apheresis (HPC-A) must be cryopreserved and stored before use in vivo. Cell processing that precedes cryopreservation of HPC-A includes volume reduction aimed at reducing the amount dimethyl sulfoxide used, as well storage space.The aim our study was assess effectiveness performed with an automated closed system, namely, Sepax...
Here, we introduce the Tabulae Paralytica —a compilation of four atlases spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas half million cells; multiome pairing transcriptomic and epigenomic measurements within same nuclei; two spatial injured spanning temporal dimensions. We integrated these into common framework to dissect molecular logic that governs responses cord. The exposed new biological principles dictate consequences SCI, including conserved divergent neuronal...
This was a retrospective review of patients with compressive cervical radiculopathy treated minimally invasive anterior foraminotomy (ACF).This study aimed to evaluate the results and complication rates ACF in consecutive series report our clinical as technique 45 for radiculopathy.ACF is motion-sparing procedure an alternative discectomy fusion (ACDF) posterior direct nerve root decompression radiculopathy.The chart recorded radiological features preoperatively postoperatively at follow-up...
Abstract. Changes in metabolic and functional activity of platelets stored as platelet concentrates plastic bags highly permeable to gases were investigated. The following parameters measured daily: pH, pO 2 , pCO HCO 3 glucose, lactic acid, dehydrogenase, cellular ATP aggregation induced by different agents (collagen ADP). As indexes lipid peroxidative damage, the levels conjugated dienes, malonyldialdehyde some antioxidant molecules such coenzyme Q10 vitamin E determined. A marked increase...
BACKGROUND: Immunomagnetic selection of peripheral blood progenitor cells (PBPCs) in patients with tumoral infiltration marrow makes it possible to reduce contamination cellular concentrates, but this procedure cannot always be used, mainly because the low count apheresis concentrates. STUDY DESIGN AND METHODS: In case two concentrates taken separately at different times were selected and cryopreserved; they thawed an automatic instrument. RESULTS: After manipulation, a concentrate...
This study presents the case of a brain-injured patient whose pathological awakening after coma and absence interaction led to diagnosis lack consciousness when standard clinical scales were administered. However, we able demonstrate conscious perception in this from initial assessments using Motor Behaviour Tool acute stage, complemented by systematic search for potential obstacles blocking his execution motor responses (pitfalls). refinement enabled prediction favourable outcome despite...
Abstract Objective. Meralgia paresthetica (MP) is a mononeuropathy of the exclusively sensory lateral femoral cutaneous nerve (LFCN) that difficult to treat with conservative treatments. Afferents from LFCN enter spinal cord through dorsal root entry zones (DREZs) innervating L2 and L3 segments. We previously showed epidural electrical stimulation can be configured steer currents laterally in order target afferents within individual DREZs. Therefore, we hypothesized this neuromodulation...
Refractory subhemispheric epilepsy has been traditionally treated by resection. The last few decades have seen the emergence of disconnective techniques, for both hemispheric and disease. aim this study was to describe technique a surgery large epileptogenic lesions involving central (perirolandic cortices), parietal, occipital lobes. This junctional cortex within hemisphere (in contrast anterior posterior quadrantotomies) presents unique challenges when contemplating complete disconnection...