A5001370668- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Trigeminal Neuralgia and Treatments
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Cerebrospinal fluid and hydrocephalus
- Facial Nerve Paralysis Treatment and Research
- Vagus Nerve Stimulation Research
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Head and Neck Surgical Oncology
- Ion channel regulation and function
- Botulinum Toxin and Related Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Transcranial Magnetic Stimulation Studies
University of California, San Francisco
2016-2025
Neurological Surgery
2016-2025
University of California System
2024
San Francisco VA Medical Center
2022
Vanderbilt University Medical Center
2017
Epilepsy Foundation
2012
Broad Center
2009-2010
Yale University
2002-2004
The development of a balance between excitatory and inhibitory synapses is critical process in the generation maturation functional circuits. Accumulating evidence suggests that neuronal activity plays an important role achieving such developing cortex, but mechanism regulates this unknown. During development, GABA, primary neurotransmitter adults, excites neurons as result high expression Na + -K -2Cl − cotransporter (NKCC1). Using NKCC1 RNA interference knockdown vivo , we show...
Previous studies have reported the presence of migrating and dividing neuronal progenitors in subventricular zone (SVZ) rostral migratory stream (RMS) postnatal mammalian brain. Although behaviour these is thought to be influenced by local signals, nature mode action signals are largely unknown. One signalling molecules known affect embryonic neurons neurotransmitter GABA. In order determine whether GABA affects via activation specific receptors, we performed cell-attached, whole-cell...
A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to hypersyncrhonous activity. During development, γ-aminobutyric acid (GABA), primary inhibitory neurotransmitter in adults, typically excites neurons due expression Na(+)-K(+)-2Cl(-) cotransporter (NKCC1). NKCC1 facilitates because it renders GABA activity excitatory through intracellular Cl(-) accumulation, while blocking with bumetanide suppresses seizures. Bumetanide...
In Parkinson's disease (PD), subthalamic nucleus beta band oscillations are decreased by therapeutic deep-brain stimulation (DBS) and this has been proposed as important to the mechanism of therapy. The globus pallidus is a common alternative target for PD with similar motor benefits DBS, but effects pallidal in not well studied, DBS on cortical function unknown. Here, 20 14 isolated dystonia human patients both genders undergoing lead implantation, we recorded local field potentials from...
OBJECTIVE Common surgical treatments for trigeminal neuralgia (TN) include microvascular decompression (MVD), stereotactic radiosurgery (SRS), and radiofrequency ablation (RFA). Although the efficacy of each procedure has been described, few studies have directly compared these treatment modalities on pain control TN. Using a large prospective longitudinal database, authors aimed to 1) compare long-term rates first-time idiopathic TN, 2) identify predictors control. METHODS The reviewed...
Malformations of cortical development (MCDs) are a major cause medically refractory epilepsy. Our aim was to examine surgical series patients with malformations determine the prognostic factors associated long-term seizure control.We conducted retrospective review 143 MCD who underwent resective surgery for Demographic, imaging, histopathologic, and variables were analyzed potential association freedom. Preoperative magnetic resonance imaging (MRI) evaluated in blind fashion classified...
The deep brain stimulation (DBS) Think Tank X was held on August 17–19, 2022 in Orlando FL. session organizers and moderators were all women with the theme neuromodulation . Dr. Helen Mayberg from Mt. Sinai, NY keynote speaker. She discussed milestones her experiences developing depression DBS. DBS founded 2012 provides an open platform where clinicians, engineers researchers (from industry academia) can freely discuss current emerging technologies as well logistical ethical issues facing...
Epilepsy surgery remains significantly underutilized. The authors recently reported that the number of lobectomies for localized intractable epilepsy in US has not changed despite implementation clear evidence-based guidelines 10 years ago supporting early referral surgery. To better understand why continues to be underused, authors' objective was carefully examine hospital-related factors related following: 1) where patients are being admitted evaluation epilepsy, 2) rates utilization...
Object Language dominance in the right hemisphere is rare. Therefore, organization of essential language sites dominant unclear, especially compared with cases involving more prevalent left hemisphere. Methods The authors reviewed medical records 15 patients who underwent awake craniotomy for tumor or epilepsy surgery and speech mapping perisylvian areas at University California, San Francisco. All were determined to have either complete right-sided bilateral by preoperative Wada testing....
Movement decoding from invasive human recordings typically relies on a distributed system employing advanced machine learning algorithms programmed into an external computer for state classification. These brain-computer interfaces are limited to short-term studies in laboratory settings that may not reflect behavior and neural states the real world. The development of implantable devices with sensing capabilities is revolutionizing study treatment brain circuits. However, it unknown whether...
Movement decoding from invasive human recordings typically relies on a distributed system employing advanced machine learning algorithms programmed into an external computer for state classification. These brain-computer interfaces are limited to short-term studies in laboratory settings that may not reflect behavior and neural states the real world. The development of implantable devices with sensing capabilities is revolutionizing study treatment brain circuits. However, it unknown whether...
INTRODUCTION: The development of adaptive deep brain stimulation (aDBS) for Parkinson’s disease (PD) to automatically change from conventional ‘gait-optimized’ frequency settings when patients walk is challenged by the lack neural biomarkers movement states in naturalistic environments. METHODS: A bi-directional neurostimulator (Summit RC+S, Medtronic) was used record unilateral activity globus pallidus (GP), premotor cortex (PM), and primary motor (M1) two PD patients. Wearable ankle...