A5001026149- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Sepsis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Diabetic Foot Ulcer Assessment and Management
- COVID-19 epidemiological studies
- Wound Healing and Treatments
- HIV, Drug Use, Sexual Risk
- Urinary Bladder and Prostate Research
- Antibiotic Use and Resistance
- Vaccine Coverage and Hesitancy
- Antimicrobial Resistance in Staphylococcus
- Inflammasome and immune disorders
- Respiratory viral infections research
- COVID-19 and Mental Health
- Urinary Tract Infections Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Diabetes and associated disorders
- COVID-19 Pandemic Impacts
National and Kapodistrian University of Athens
2008-2025
Democritus University of Thrace
2015-2024
University Hospital of Alexandroupolis
2013-2024
University General Hospital Attikon
2005-2024
University of Crete
2024
Hoag Memorial Hospital Presbyterian
2024
University of Nicosia
2024
Duke University Health System
2023
Centre of Excellence for Health, Immunity and Infections
2023
University of Copenhagen
2023
Abstract Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative increased risk progression coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at progressing failure as identified by plasma suPAR ≥6 ng ml −1 , 85.9% ( n = 510) whom were receiving dexamethasone. At day 28, adjusted...
Severe acute respiratory syndrome coronavirus 2 infection has evolved into a global pandemic. Low-dose colchicine combines anti-inflammatory action with favorable safety profile.To evaluate the effect of treatment on cardiac and inflammatory biomarkers clinical outcomes in patients hospitalized disease 2019 (COVID-19).In this prospective, open-label, randomized trial (the Greek Study Effects Colchicine COVID-19 Complications Prevention), 105 were 1:1 allocation from April 3 to 27, 2020,...
It was studied if early suPAR-guided anakinra treatment can prevent severe respiratory failure (SRF) of COVID-19.A total 130 patients with suPAR ≥6 ng/ml were assigned to subcutaneous 100 mg once daily for 10 days. Primary outcome SRF incidence by day 14 defined as any ratio below 150 mmHg necessitating mechanical or non-invasive ventilation. Main secondary outcomes 30-day mortality and inflammatory mediators; 28-day WHO-CPS explored. Propensity-matched standard-of care comparators...
A significant proportion of people infected with SARS-CoV-2 report a new onset smell or taste loss. The duration the chemosensory impairment and predictive factors recovery are still unclear. We aimed to investigate prevalence, temporal course predictors in patients who suffered from varying disease severity. Consecutive adult diagnosed be via reverse-transcription–polymerase chain reaction (RT-PCR) at two coronavirus disease-2019 (COVID-19) Reference Hospitals were contacted complete survey...
The pressure of the COVID-19 pandemic on healthcare systems led to limited roles infectious diseases services, increased rates irrational use antimicrobials, and incidence infections by multidrug-resistant microorganisms. aim present study is evaluate antimicrobial resistance management bloodstream before during at University General Hospital Alexandroupolis (Greece).This a retrospective conducted from January 2018 December 2022. Data were collected Microbiology Laboratory per semester...
The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. bacterium possesses multitude mechanisms to escape human immune system. consequences A. on morbidity and mortality, as well financial resources, remain dire. Furthermore, superinfections have also occurred during COVID-19 pandemic. While prevention is important, antibiotic armamentarium most essential factor these infections. main problem notorious resistance profile...
Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning progression to respiratory failure (SRF) or death, access suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating C-reactive protein, D- dimers, interleukin-6,...
Abstract Background Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes transitions associated response anakinra (human interleukin 1 receptor antagonist) in participants the SAVE-MORE trial. Methods Adult hospitalized radiological findings PCR-confirmed severe pneumonia caused by SARS-CoV-2 plasma-soluble urokinase plasminogen activator levels ≥ 6 ng/ml trial (NCT04680949) were characterized at...
Introduction: The reduced implementation of surveillance programs and limited bedside infectious diseases consultations due to the pressure COVID-19 pandemic in healthcare systems led increased rates irrational use antimicrobials incidence infections by multidrug-resistant microorganisms. aim present study is evaluate antimicrobial resistance management bloodstream before during at University General Hospital Alexandroupolis (Greece). Material-Methods: This a retrospective conducted from...
Vaccination against SARS-CoV-2 and the prevalence of Omicron variants have reduced risk severe clinical progress COVID-19. However, breakthrough infections has increased, early administration an effective antiviral treatment is significant in order to prevent progression COVID-19 vulnerable patients with comorbidities.Adults confirmed infection were included a matched-pair retrospective study based on age, gender, comorbidities vaccination status. They divided into two groups: group A (n =...
Introduction: Neonates born at 37-38 weeks of gestation have been shown to face a relatively higher risk mortality and various morbidities compared those full term (39-41 weeks). The aim this study was conduct comprehensive analysis early birth rate (ETBR) trends in Greece from 1980 2023. Materials methods: Data on live births 2023 were obtained the Hellenic Statistical Authority (ELSTAT), based certificate records. A total 4,595,020 categorized by gestational age. annual ETBR calculated as...
Metabolic disorders associated with atherosclerosis and cardiovascular disease have been described in "HIV-infected" individuals. We investigated (i) whether normotensive individuals hypertensive patients similarities regarding their arterial elastic properties (ii) the effect of highly active antiretroviral therapy (HAART) metabolic factors on stiffness.In a case-control study, we compared measurements pulse wave velocity (PWV), blood pressure, markers profile 56 normotensive, (mean age 40...
Abstract We aimed to develop presepsin as a marker of diagnosis severe infections either bacterial and viral origin. The derivation cohort was recruited from 173 hospitalized patients with acute pancreatitis or post-operative fever infection suspicion aggravated by at least one sign the quick sequential organ failure assessment (qSOFA). first validation 57 admissions emergency department qSOFA second 115 COVID-19 pneumonia. Presepsin measured in plasma PATHFAST assay. Concentrations more...
The SAVE-MORE trial demonstrated that anakinra treatment in COVID-19 pneumonia with plasma soluble urokinase plasminogen activator (suPAR) levels of 6 ng/mL or more was associated 0.36 odds for a worse outcome compared to placebo when expressed by the WHO-Clinical Progression Scale (CPS) at day 28. Herein, we report results subgroup analyses and long-term outcomes.
A metabolic syndrome associated with atherosclerosis and cardiovascular disease has been described in HIV-positive individuals. In the present study we investigated whether individuals CAD (coronary artery disease) patients have similarities their vascular function structure. a case-control study, compared measurements of carotid IMT (intima-media thickness) brachial FMD (flow-mediated vasodilation) age- sex-matched controls similar risk factors established CAD. Seventy-one HIV patients, age...