A5014879023- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Oral Health Pathology and Treatment
- Galectins and Cancer Biology
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Chemokine receptors and signaling
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Lymphoma Diagnosis and Treatment
- Diabetes and associated disorders
- Vasculitis and related conditions
- Lymphatic System and Diseases
- Growth Hormone and Insulin-like Growth Factors
- T-cell and B-cell Immunology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Fibromyalgia and Chronic Fatigue Syndrome Research
National and Kapodistrian University of Athens
2019-2024
Biomedical Research Foundation of the Academy of Athens
2024
Academy of Athens
2024
Centre Hospitalier Régional Universitaire de Brest
2023
Inserm
2023
Ospedale Santa Maria della Misericordia di Udine
2022-2023
University of Perugia
2021-2023
University of Pisa
2021-2023
University of Florence
2023
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2021-2023
It was studied if early suPAR-guided anakinra treatment can prevent severe respiratory failure (SRF) of COVID-19.A total 130 patients with suPAR ≥6 ng/ml were assigned to subcutaneous 100 mg once daily for 10 days. Primary outcome SRF incidence by day 14 defined as any ratio below 150 mmHg necessitating mechanical or non-invasive ventilation. Main secondary outcomes 30-day mortality and inflammatory mediators; 28-day WHO-CPS explored. Propensity-matched standard-of care comparators...
Objectives To study the clinical, serological and histologic features of primary Sjögren’s syndrome (pSS) patients with early (young ≤35 years) or late (old ≥65 onset to explore differential effect on lymphoma development. Methods From a multicentre population 1997 consecutive pSS patients, those disease onset, were matched compared control middle age onset. Data driven analysis was applied identify independent variables associated in both groups. Results Young (19%, n=379), had higher...
Background: To compare the clinical, serological and histologic features between male female patients with Sjögren’s syndrome (SS) explore potential effect of gender on lymphoma development. Methods: From a multicenter population (Universities Udine, Pisa Athens, Harokopion Ioannina (UPAHI)) consisting consecutive SS fulfilling 2016 ACR/EULAR criteria, were identified, matched compared controls. Data-driven multivariable logistic regression analysis was applied to identify independent...
Primary Sjögren's Syndrome (pSS) carries the highest risk for non-Hodgkin's lymphoma (NHL) development among systemic autoimmune diseases. However, paucity of data on long-term survival those patients and lack established predictors each histologic subtype prompted our present study.We retrospectively analysed 121 diagnosed with NHL according to WHO classification criteria. All fulfilled 2016 ACR-EULAR criteria pSS. Cumulative clinical, laboratory, radiologic, treatment regimens were...
Tissue-resident memory cells (Trm) are a subset of T residing persistently and long-term within specific tissues that contribute to persistent inflammation tissue damage. We characterised the phenotype function Trm role CD103 in primary Sjogren's syndrome (pSS).
To describe the clinical spectrum of cryoglobulinemic vasculitis (CV) in primary Sjögren's syndrome (pSS), investigate its relation to lymphoma and identify differences with hepatitis C virus (HCV) related CV.From a multicentre study population consecutive pSS patients, those who had been evaluated for cryoglobulins fulfilled 2011 classification criteria CV were identified retrospectively. pSS-CV patients matched without (1:2) HCV-CV (1:1). Clinical, laboratory outcome features analyzed. A...
Parotid swelling (PSW) is a major predictor of non-Hodgkin's lymphoma (NHL) in primary SS (pSS). However, since detailed information on the time onset and duration PSW scarce, this was investigated to verify whether it may lead further improved prediction. NHL localization concomitantly studied evaluate role parotid gland microenvironment pSS-related lymphomagenesis.A multicentre study conducted among patients with pSS who developed B cell during follow-up matched controls that did not...
Humoral immunity has emerged as a vital immune component against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nevertheless, subset of recovered Coronavirus Disease-2019 (COVID-19) paucisymptomatic/asymptomatic individuals do not generate an antibody response, constituting paradox. We assumed that immunodiagnostic assays may operate under competitive format within the context antigenemia, potentially explaining this phenomenon. present case where persistent...
Recent studies suggest that elevated CXCL13 serum levels in patients with primary Sjögren's syndrome (pSS) associate minor salivary gland (MSG) histologic features, disease severity, as well high-risk status for non-Hodgkin lymphoma (NHL) development and NHL itself. In contrast, limited discriminative value of saliva has been reported. Prompt by these reports, we sought to validate the clinical utility investigating potential correlations MSG histopathologic [including CXCL13+-cell number,...
Primary Sjögren syndrome (pSS) is a systemic autoimmune epithelitis, potentially affecting salivary epithelium, biliary and hepatocytes. Common immunological mechanisms might cause clinically silent liver inflammation, combined with non-alcoholic fatty disease (NAFLD), fibrosis (LF) may occur. No studies have explored the occurrence of LF in context NAFLD among pSS patients.Consecutive patients from rheumatology outpatient clinic Department Pathophysiology individuals evaluated hepatology...
Abstract: Giant Cell Arteritis (GCA) is an autoimmune/autoinflammatory disease affecting large vessels in patients over 50 years old. The presents as acute inflammatory response with two phenotypes, cranial-GCA and Large Vessel Vasculitis (LV)-GCA, involving the thoracic aor-ta its branches. 18F-fluorodeoxyglucose positron emission tomography-computed tomogra-phy (18F-FDG PET-CT) among imaging techniques contributing to diagnosis of systemic disease. However, association soluble markers...