A5027453586- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Oral Health Pathology and Treatment
- Vasculitis and related conditions
- Diabetes and associated disorders
- Galectins and Cancer Biology
- Inflammasome and immune disorders
- Growth Hormone and Insulin-like Growth Factors
- Rheumatoid Arthritis Research and Therapies
- Lymphatic System and Diseases
- Renal Diseases and Glomerulopathies
- Liver Diseases and Immunity
- Ophthalmology and Eye Disorders
- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- AI in cancer detection
- Glycosylation and Glycoproteins Research
- Inflammatory Myopathies and Dermatomyositis
- Chemokine receptors and signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
National and Kapodistrian University of Athens
2016-2025
Laiko General Hospital of Athens
2015-2024
Academy of Athens
2024
Biomedical Research Foundation of the Academy of Athens
2024
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2021-2023
University of Pisa
2023
University of Perugia
2023
Autoimmune Technologies (United States)
2022
Center for Rheumatology
2022
University Medical Center Groningen
2022
Clinically significant renal involvement in patients with primary Sjögren syndrome (pSS) has been described previously only isolated case reports. The prevalence and significance of the 2 syndromes, interstitial nephritis (IN) glomerulonephritis (GMN), are not well known. In a cohort 471 pSS who were followed for mean 10 years, 20 (4.2%) developed overt disease. Eighteen underwent percutaneous biopsy; declined. Ten had IN, 8 GMN, presented both entities. Glomerular histology disclosed...
Objective To estimate the prevalence and investigate clinical features outcome of clinically significant renal involvement in a large cohort patients with primary Sjögren's syndrome (SS). Methods Among 715 who met American–European Consensus Group criteria for SS, those were identified their immunologic recorded. The prognosis SS was assessed by appearance any following major outcomes: death, hemodialysis, chronic failure (CRF), lymphoma. Kaplan‐Meier analysis applied to compare death rates...
Objectives To study the clinical, serological and histologic features of primary Sjögren’s syndrome (pSS) patients with early (young ≤35 years) or late (old ≥65 onset to explore differential effect on lymphoma development. Methods From a multicentre population 1997 consecutive pSS patients, those disease onset, were matched compared control middle age onset. Data driven analysis was applied identify independent variables associated in both groups. Results Young (19%, n=379), had higher...
The novel mRNA-based vaccines against SARS-CoV-2 display encouraging safety and efficacy profiles. However, there is a paucity of data regarding their immunogenicity in patients with liver diseases (PWLD), especially those cirrhosis. We prospectively assessed anti-SARS-CoV-2 S-spike IgG antibodies neutralizing activity fully vaccinated PWLD (n = 87) controls 40). Seroconversion rates were 97.4% (37/38) cirrhotic PWLD, 87.8% (43/49) non-cirrhotic 100% (40/40) controls. Adequate was detected...
Objectives Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible pathogenetic role cellular senescence. To address this question, we applied an established senescence specific multimarker algorithm in temporal artery biopsies (TABs) GCA patients. Methods 75(+) TABs from patients, 22(−) polymyalgia rheumatica (PMR) patients and 10(−) non-GCA/non-PMR were retrospectively retrieved analysed. Synovial tissue specimens with inflammatory arthritis aorta used as...
Background: To compare the clinical, serological and histologic features between male female patients with Sjögren’s syndrome (SS) explore potential effect of gender on lymphoma development. Methods: From a multicenter population (Universities Udine, Pisa Athens, Harokopion Ioannina (UPAHI)) consisting consecutive SS fulfilling 2016 ACR/EULAR criteria, were identified, matched compared controls. Data-driven multivariable logistic regression analysis was applied to identify independent...
Primary Sjögren's Syndrome (pSS) carries the highest risk for non-Hodgkin's lymphoma (NHL) development among systemic autoimmune diseases. However, paucity of data on long-term survival those patients and lack established predictors each histologic subtype prompted our present study.We retrospectively analysed 121 diagnosed with NHL according to WHO classification criteria. All fulfilled 2016 ACR-EULAR criteria pSS. Cumulative clinical, laboratory, radiologic, treatment regimens were...
To describe the clinical spectrum of cryoglobulinemic vasculitis (CV) in primary Sjögren's syndrome (pSS), investigate its relation to lymphoma and identify differences with hepatitis C virus (HCV) related CV.From a multicentre study population consecutive pSS patients, those who had been evaluated for cryoglobulins fulfilled 2011 classification criteria CV were identified retrospectively. pSS-CV patients matched without (1:2) HCV-CV (1:1). Clinical, laboratory outcome features analyzed. A...
To explore the presence of neutrophil extracellular traps (NETs) in inflamed temporal artery biopsies (TABs) patients with GCA.Ten GCA [five limited and five associated generalized vascular involvement, as defined by 18F-fluorodeoxyglucose PET CT (PET/CT)] eight PMR were studied. The presence, location, quantitation decoration NETs IL-6, IL-1β IL-17A assessed TABs at time disease diagnosis tissue immunofluorescence confocal microscopy. Paired serum levels IL-6 also evaluated all patients.All...
For many decades, the clinical unmet needs of primary Sjögren's Syndrome (pSS) have been left unresolved due to rareness disease and complexity underlying pathogenic mechanisms, including pSS-associated lymphomagenesis process. Here, we present HarmonicSS cloud-computing exemplar which offers beyond state-of-the-art data analytics services address pSS needs, development lymphoma classification models identification biomarkers for lymphomagenesis. The users platform able successfully...