A5109577320- Salivary Gland Disorders and Functions
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Systemic Sclerosis and Related Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- Inflammatory mediators and NSAID effects
- Otitis Media and Relapsing Polychondritis
- Osteoarthritis Treatment and Mechanisms
- IgG4-Related and Inflammatory Diseases
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal pain and rehabilitation
- Liver Disease Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Pancreatitis Pathology and Treatment
- Tuberculosis Research and Epidemiology
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Myopathies and Dermatomyositis
- Liver Diseases and Immunity
- Chronic Lymphocytic Leukemia Research
- Mycobacterium research and diagnosis
- Antiplatelet Therapy and Cardiovascular Diseases
National and Kapodistrian University of Athens
2018-2025
University of Ioannina
2023-2024
General Hospital of Attica
2023
Asklepion
2023
Mitera Hospital
2023
Hygeia Hospital
2023
University General Hospital Attikon
2023
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2022
Laiko General Hospital of Athens
2020
Aristotle University of Thessaloniki
2016
Objectives To study the clinical, serological and histologic features of primary Sjögren’s syndrome (pSS) patients with early (young ≤35 years) or late (old ≥65 onset to explore differential effect on lymphoma development. Methods From a multicentre population 1997 consecutive pSS patients, those disease onset, were matched compared control middle age onset. Data driven analysis was applied identify independent variables associated in both groups. Results Young (19%, n=379), had higher...
Objectives Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible pathogenetic role cellular senescence. To address this question, we applied an established senescence specific multimarker algorithm in temporal artery biopsies (TABs) GCA patients. Methods 75(+) TABs from patients, 22(−) polymyalgia rheumatica (PMR) patients and 10(−) non-GCA/non-PMR were retrospectively retrieved analysed. Synovial tissue specimens with inflammatory arthritis aorta used as...
Background: To compare the clinical, serological and histologic features between male female patients with Sjögren’s syndrome (SS) explore potential effect of gender on lymphoma development. Methods: From a multicenter population (Universities Udine, Pisa Athens, Harokopion Ioannina (UPAHI)) consisting consecutive SS fulfilling 2016 ACR/EULAR criteria, were identified, matched compared controls. Data-driven multivariable logistic regression analysis was applied to identify independent...
To describe the clinical spectrum of cryoglobulinemic vasculitis (CV) in primary Sjögren's syndrome (pSS), investigate its relation to lymphoma and identify differences with hepatitis C virus (HCV) related CV.From a multicentre study population consecutive pSS patients, those who had been evaluated for cryoglobulins fulfilled 2011 classification criteria CV were identified retrospectively. pSS-CV patients matched without (1:2) HCV-CV (1:1). Clinical, laboratory outcome features analyzed. A...
To explore the presence of neutrophil extracellular traps (NETs) in inflamed temporal artery biopsies (TABs) patients with GCA.Ten GCA [five limited and five associated generalized vascular involvement, as defined by 18F-fluorodeoxyglucose PET CT (PET/CT)] eight PMR were studied. The presence, location, quantitation decoration NETs IL-6, IL-1β IL-17A assessed TABs at time disease diagnosis tissue immunofluorescence confocal microscopy. Paired serum levels IL-6 also evaluated all patients.All...
Abstract Background Osteoarthritis (OA) represents a leading cause of disability with limited data available for the Greek patients. Objectives To evaluate impact moderate to severe symptomatic hip/knee OA under treatment on physical performance and quality life. Methods A non-interventional, cross-sectional, epidemiological study patients moderate/severe OA, recruited in single visit from 9 expert sites Athens, Greece. Assessments were based commonly used outcome scales: Hip Outcome Score...
Giant Cell Arteritis-(GCA) is an inflammatory disease following a chronic, relapsing course. The metabolic alterations related to the intense process during active phase and rapid impact of steroid treatment, remain unknown. study aims investigate serum metabolome in inactive state.110 samples from 50 patients [33-GCA 17-Polymyalgia rheumatica-(PMR)] at 3 time points, 0-(V1: disease), 1 6 months-(V2 V3: remission) treatment with glucocorticosteroids (GCs), were subjected Nuclear Magnetic...
Miller-Fisher syndrome (MFS) is considered as a variant of the Guillain-Barre (GBS) and its characteristic clinical features are ophthalmoplegia, ataxia, areflexia. Typically, it associated with anti-GQ1b antibodies; however, significant percentage (>10%) these patients seronegative. Here, we report 67-year-old female patient who presented typical MFS. Workup revealed antibodies against glutamic acid decarboxylase (GAD) in relatively high titers while GQ1b were negative. Neurological...
Primary Sjögren syndrome (pSS) is a systemic autoimmune epithelitis, potentially affecting salivary epithelium, biliary and hepatocytes. Common immunological mechanisms might cause clinically silent liver inflammation, combined with non-alcoholic fatty disease (NAFLD), fibrosis (LF) may occur. No studies have explored the occurrence of LF in context NAFLD among pSS patients.Consecutive patients from rheumatology outpatient clinic Department Pathophysiology individuals evaluated hepatology...
Abstract: Giant Cell Arteritis (GCA) is an autoimmune/autoinflammatory disease affecting large vessels in patients over 50 years old. The presents as acute inflammatory response with two phenotypes, cranial-GCA and Large Vessel Vasculitis (LV)-GCA, involving the thoracic aor-ta its branches. 18F-fluorodeoxyglucose positron emission tomography-computed tomogra-phy (18F-FDG PET-CT) among imaging techniques contributing to diagnosis of systemic disease. However, association soluble markers...
Objective To assess the economic burden of moderate to severe osteoarthritis (OA) management for patients and health care system in Greece. Design A noninterventional, cross-sectional, prospective, epidemiological analysis data from medical records with OA, recruited a single visit 9 sites Outcomes included resource use (direct/indirect costs) associated this patient population. Results total 164 were analysis: mean age was 70.5 years, majority participants females (78.7%). The presence...
Perinuclear anti-neutrophilic cytoplasmic antibodies (P-ANCA) recognize heterogeneous antigens, including myeloperoxidase (MPO), lactoferrin, elastase, cathepsin-G and bactericidal/permeability-increasing protein. Although P-ANCA have diagnostic utility in vasculitides, they may also be found patients with various other systemic autoimmune rheumatic diseases (SARDs). Nevertheless, the clinical significance targets recognized by such remain unclear. For this purpose, herein we investigated...