A5084950243- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- Autism Spectrum Disorder Research
- RNA regulation and disease
- Lysosomal Storage Disorders Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Gaze Tracking and Assistive Technology
- Autoimmune Neurological Disorders and Treatments
- Nuclear Receptors and Signaling
- Transcranial Magnetic Stimulation Studies
- Genetics and Neurodevelopmental Disorders
- Assistive Technology in Communication and Mobility
- Vascular Malformations Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Genetic Neurodegenerative Diseases
- Epilepsy research and treatment
- Neurological and metabolic disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Neurogenetic and Muscular Disorders Research
- Migraine and Headache Studies
- Prion Diseases and Protein Misfolding
G. Papanikolaou General Hospital
2011-2024
Parkinson's UK
2024
Aristotle University of Thessaloniki
2012-2023
National and Kapodistrian University of Athens
2014
AHEPA University Hospital
1989-1991
Importance Deep brain stimulation of the subthalamic nucleus (STN-DBS) improves quality life (QOL) in patients with advanced Parkinson disease (PD). However, controlled studies more than 3 years follow-up are lacking. Objective To investigate long-term effects STN-DBS on QOL compared standard-of-care medication (MED). Design, Setting, and Participants In this prospective, observational, quasi-experimental, longitudinal nonrandomized trial, 183 were screened for eligibility 167 enrolled from...
Background/Objective: The aim of this study was to describe the rate and clinical predictors cognitive decline in dementia with Lewy bodies (DLB), compare findings Alzheimer’s disease (AD) Parkinson’s (PDD) patients. Methods: Longitudinal scores for Mini-Mental State Examination (MMSE) 1,290 patients (835 DLB, 198 PDD, 257 AD) were available from 18 centers up three years longitudinal data. Linear mixed effects analyses appropriate covariates used model MMSE over time. Several subgroup...
ABSTRACT Background G209A SNCA mutation carriers represent an important group of genetic PD. We describe motor and nonmotor features carriers. Methods Longitudinal clinical assessments over 2 years were collected in 22 symptomatic 8 asymptomatic Motor rating scales administered. Correlations performed between variables disease duration or age. Penetrance was calculated using Kaplan‐Meier survival curves. Results Asymptomatic did not manifest clear premotor symptoms, but often reported that...
We evaluated pupil light reflex (PLR) in patients with Parkinson's disease (PD) and normal controls by means of pupillometry explored its possible relation to clinical characteristics parkinsonian patients. PLR was using 66 PD without evidence autonomic dysfunction 44 healthy matched controls. elicited single flash stimuli 24.6 candelas/m(2) intensity 20 ms duration, six parameters were studied after full recording pupil's movement. A significant increase latency (T1) decrease amplitude...
To determine the frequency, distribution, and clinical features of Parkinson disease (PD) with PINK1 mutations.Retrospective genetic review.University hospital.We performed extensive mutation analyses in 414 PD patients negative for parkin mutations (mean [SD] age at onset, 42.8 [14.3] years), including 391 unrelated (190 sporadic 201 probands familial PD) from 13 countries.We found 10 9 families identified 7 novel (2 homozygous [p.D297MfsX22 p.W437R] 5 single heterozygous [p.A78V,...
Objectives To compare the dopaminergic neuronal imaging features of different subtypes genetic Parkinson's Disease. Methods A retrospective study diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen each case. The right:left asymmetry index striatal calculated. Results Scans were available from 37 monogenetic disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12...
Abstract Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, affecting more than 1% of population above 60 years old with both motor and non-motor symptoms escalating severity as it progresses. Since cannot be cured, treatment options focus on improvement PD symptoms. In fact, evidence suggests that early intervention has potential to slow down symptom progression improve general quality life in long term. However, initial are usually very subtle and, a result,...
Abstract The motor and neuropsychological abnormalities in eight Greek patients with Parkinson's disease (PD) carrying the α‐synuclein gene mutation (G209A) were studied. These (five men, three women) belonged to six different families. Their symptoms started between 32–50 years of age (mean ± SD, 39.7 7.6 years) they had a mean duration 5.4 2.1 (range, 2–9 at time examination. Rigidity bradykinesia predominated both onset as well later stages rest tremor was relatively uncommon....
Parkinson's Disease (PD) is a neurodegenerative disorder with early non-motor/motor symptoms that may evade clinical detection for years after the disease onset due to their mildness and slow progression. Digital health tools process densely sampled data streams from daily human-mobile interaction can objectify monitoring of behavioral patterns change appearance PD-related signs. In this context, touchscreens capture micro-movements fingers during natural typing; an unsupervised activity...
Abstract Fine-motor impairment (FMI) is progressively expressed in early Parkinson’s Disease (PD) patients and now known to be evident the immediate prodromal stage of condition. The clinical techniques for detecting FMI may not robust enough here, we show that subtle PD can effectively estimated from analysis natural smartphone touchscreen typing via deep learning networks, trained stages initialization fine-tuning. In a validation dataset 36,000 sessions 39 subjects (17 healthy/22 with...
Wide comprehension of genetic features cerebral cavernous malformations (CCM) represents the starting point to better manage patients and risk rating in relatives. The causative mutations spectrum is constantly growing. KRIT1, CCM2, PDCD10 are three loci date linked familial CCM development, although germline have also been detected affected by sporadic forms. In this context, main challenge draw up criteria formulate genotype-phenotype correlations. Clearly, factors determining incomplete...
Hypomimia, i.e. reduction in the expressiveness of face, is a cardinal sign PD, often present at its early stages. Within EU-funded i-Prognosis project (http://www.i-prognosis.eu), and unobtrusive Parkinson's disease detection tests are developed, based on interaction users with everyday technological devices. The selfie analysis module translates facial expression features into an index reflecting severity PD hypomimia symptoms that affect variability patients' expressions. Monitoring such...
Abstract Various instruments with good psychometric properties have been developed for the assessment of health‐related quality life (HRQoL) in Parkinson's disease, (PD); however, everyday practice a brief questionnaire is needed quick screening patients. We present process development and validation Greek version PD questionnaire‐8 (PDQ‐8 GrV ), which an 8‐item scale derived from well‐known measure evaluation HRQoL PD, (PDQ‐39). PDQ‐8 was applied to 228 nondemented Data PDQ‐39 were also...
Pharmacological data and early clinical experience have suggested that the calcium entry blocker flunarizine may be a valuable gain in prophylaxis of migraine. This was supported by study 20 patients with classical migraine who were, after drug free run-in phase, orally treated either placebo or (10 mg at night) for 3 to 4 months. Flunarizine significantly reduced frequency, duration severity attacks. A corrected index, based on these variables 82% group but increased 66% control patients....
Antibody-mediated autoimmune encephalopathies comprise a group of severe conditions with varying degree motor and cognitive symptoms that respond to immunotherapies.1 The associated antibodies are directed against intracellular targets, such as the classic paraneoplastic autoantigens Hu, Yo, Ri, CV2, Ma2/Ta, or enzyme GAD, cell surface antigens receptors ion channels.
Fatigue is a frequent symptom in Parkinson disease (PD), but its pathogenesis remains obscure. may be influenced by depression and motor disability, immunological factors have been also implicated. The purpose of the study was to assess fatigue PD patients relation various factors.Forty 26 normal matched controls were studied. assessed Severity Scale (FSS). Beck Depression Inventory (BDI) employed for screening. following estimated: a) T- B-lymphocytes, T-lymphocyte subsets...