A5048116774- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Sleep and Wakefulness Research
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Biotin and Related Studies
- Hereditary Neurological Disorders
- Connexins and lens biology
- Botulinum Toxin and Related Neurological Disorders
- Glycogen Storage Diseases and Myoclonus
- Ion channel regulation and function
- Neurological disorders and treatments
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Complement system in diseases
- Long-Term Effects of COVID-19
National and Kapodistrian University of Athens
2016-2025
Evangelismos Hospital
2020
University General Hospital Attikon
2020
Piedmont Athens Regional
2020
Alexander Fleming Biomedical Sciences Research Center
2016
Biomedical Research Foundation of the Academy of Athens
2016
Molecular Oncology (United States)
2016
Thomas Jefferson University
2013-2015
Universität Innsbruck
2015
Innsbruck Medical University
2015
<h3>Objective</h3> To investigate the pathophysiologic mechanism of encephalopathy and prolonged comatose or stuporous state in severally ill patients with coronavirus disease 2019 (COVID-19). <h3>Methods</h3> Eight COVID-19 signs were tested for antibodies to severe acute respiratory syndrome 2 (SARS-CoV-2) serum CSF using a Food Drug Administration-approved independently validated ELISA. Blood-brain barrier (BBB) integrity immunoglobulin G (IgG) intrathecal synthesis further albumin IgG...
Background The incidence and prevalence of CNS involvement in SLE remains unclear owing to conflicting results the published studies. aim study was evaluate major definite events patients. Methods 370 patients with no previous history were prospectively evaluated a tertiary hospital referral center for 3 years. Major manifestations codified according ACR definitions, including chorea, aseptic meningitis, psychosis, seizures, myelopathy, demyelinating syndrome, acute confusional state...
Optic neuritis (ON) is an inflammatory disease of the optic nerve characterized by pain and visual loss often associated with multiple sclerosis (MS) or neuromyelitis optica spectrum disorders (NMOSD). Recent evidence suggests that certain forms ON are anti–myelin oligodendrocyte glycoprotein (MOG) antibodies.1,–4 A distinct clinical subset episodes involve one both nerves, occur within months weeks, do not any other radiologic findings. This entity, defined as either recurrent (rON)...
In stiff person syndrome (SPS), an antibody-mediated impaired γ-aminobutyric acidergic (GABAergic) neurotransmission is believed to cause muscle stiffness and spasms. Most patients improve with GABA-enhancing drugs intravenous immunoglobulin, but some respond poorly remain disabled. The need for more effective therapy prompted a trial the anti-CD20 monoclonal antibody rituximab.This was placebo-controlled randomized of rituximab (2 biweekly infusions 1g each). primary outcome change in...
Stiff Person Syndrome (SPS) is an under-diagnosed disorder that affects mobility and the quality of life affected patients. The aim study to describe natural history SPS, extent accumulated disability associated clinical immunological features in patients followed for up 8 years a single center. Our collective cohort included 57 SPS Additionally, 32 these were examined every 6 months two-year period longitudinal protocol, assess disease progression using quantitative measures stiffness...
Brain glucose sensing is critical for healthy energy balance, but how appropriate neurocircuits encode both small changes and large background values of levels unknown. Here, we report several features hypothalamic orexin neurons, cells essential normal wakefulness feeding: (i) A distinct group neurons exhibits only transient inhibitory responses to sustained rises in sugar levels; (ii) this strategy involves time-dependent recovery from inhibition via adaptive closure leak-like K(+)...
Introduction: Cross-reactivity to SARS-CoV-2 antigenic peptides has been detected on T-cells from pre-pandemic donors due recognition of conserved protein fragments within members the coronavirus's family. Further, preexisting antibodies recognizing with epitopes in spike region have now seen uninfected individuals. High-dose Intravenous Immunoglobulin (IVIg), derived thousands healthy donors, contains natural IgG against various antigens which can be both IVIg preparations and serum...
The prevalence of peripheral neuropathy in patients with Sjögren syndrome remains unclear owing to conflicting results the published series, numbers ranging from 2% over 60% patients. Whether is a feature systemic or glandular disease whether it related circulating antineuronal antibody also uncertain.The authors reviewed records primary (pSS), fulfilling Revised European-American Classification Criteria, seen their department 1992 2009. previously recorded neuropathic features were...
High titers of autoantibodies to glutamic acid decarboxylase (GAD) are well documented in association with stiff person syndrome (SPS). Glutamic is the rate-limiting enzyme synthesis γ-aminobutyric (GABA), and impaired function GABAergic neurons has been implicated pathogenesis SPS. Autoantibodies GAD might be causative agent or a disease marker.To investigate characteristics potential pathogenicity patients SPS related disorders.Retrospective cohort study laboratory investigation.Weatherall...
New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes group of patients NORSE who all demonstrated typical magnetic resonance imaging (MRI) sign characterized by bilateral lesions claustrum. The includes 31 (12 personal 19 published cases; 17 females; mean age 25 years). Fever preceded (SE) 28 patients, 6 days. SE was...
COVID-19 vaccination leads to a less intense humoral response in patients with multiple myeloma (MM) compared healthy individuals, whereas the SARS-CoV-2-specific immunity fades over time. The purpose of this study was explore kinetics SARS-CoV-2 neutralizing antibodies (NAbs) MM after BNT162b2 mRNA vaccine, focusing on their before (B4D) and at 1 month fourth (M1P4D). Overall, 201 median age 67 years were included, 114 (56.7%) men. NAbs levels B4D 80.0% (±3.5%) M1P4D they increased value...
The aim of this study was to identify genetic markers and immunologic characteristics glutamic acid decarboxylase (GAD) antibody-positive patients with stiff-person syndrome (SPS). We conducted systemic immunogenetic studies in 11 GAD-positive patients: 8 sporadic SPS 3 from a three-generation family very high GAD-ab titers but diverse symptomatology (one GAD-epilepsy 2 only diabetes), by performing complete profile whole-exome sequencing analysis. Two genes expressed immune neuronal tissues...