A5069448821- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Peripheral Neuropathies and Disorders
- Amyotrophic Lateral Sclerosis Research
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Restless Legs Syndrome Research
- Mitochondrial Function and Pathology
- Neurological and metabolic disorders
- Botulinum Toxin and Related Neurological Disorders
- Neurogenetic and Muscular Disorders Research
- Neurosurgical Procedures and Complications
- Medical and Biological Sciences
- Medical Imaging Techniques and Applications
- Vestibular and auditory disorders
- Hereditary Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Parkinson's Disease and Spinal Disorders
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Fetal and Pediatric Neurological Disorders
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
Hiratsuka City Hospital
1996-2023
Shonan Oiso Hospital
2016-2020
Tokai University
2006-2017
Hokkaido University
2008
The University of Tokyo
2008
Sanin Rosai Hospital
2008
Oregon Health & Science University
1998
Neurology, Inc
1996
Tokai University Hospital
1991
Mount Sinai Medical Center
1987-1991
Abstract Sixteen normal volunteers were studied with [F-18] fluorodeoxyglucose and positron emission tomography scans during behavioral activation a verbal fluency test, 35 age-matched controls resting-state scans. There was an overall increase of the cerebral glucose metabolic rate 23.3% activation, compared to resting state, greatest in bilateral temporal frontal lobes. A negative correlation between test performance scores indices metabolism found frontal, temporal, parietal regions....
In 76 normal volunteers studied by positron emission tomography, with [ 18 F]fluorodeoxyglucose, CMR glu was significantly lower in the elderly as compared young subjects and higher females relative to males. However, 58 of these who also had magnetic resonance imaging scans, age gender were found be unrelated , when effects brain volume atrophy on partialed out using covariate analyses. Individually, have a significant effect explaining ∼17% variability measures ∼8% variance . Together two...
Thirty-one patients with probable Alzheimer's disease and 11 memory disorders, attributable to multiple cerebral infarctions, were studied using 18-F-fluorodeoxyglucose-positron emission tomography scans. Asymmetry in glucose metabolism within these diagnostic groups was assessed by comparison the metabolic rates obtained age-equivalent healthy control subjects. A significantly greater number of individuals both patient exhibited predominant left rather than right hemisphere hypometabolism....
Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated several factors such as depression fatigue. This study aimed to evaluate in Japanese MS the association between apathy, fatigue, depression. The Brief Repeatable Battery Neuropsychological tests (BRB-N) was performed 184 163 healthy controls matched age, gender, education. Apathy Scale (AS), Fatigue Questionnaire (FQ), Beck Depression Inventory Second Edition...
Positron-emission tomography (PET) was used to study regional cerebral metabolic activity during oral reading in right-handed adult males with, and without a childhood family history of developmental dyslexia. Significant group differences normalized values were revealed prefrontal cortex the lingual (inferior) region occipital lobe. Lingual bilaterally higher for dyslexic than normal readers. In contrast asymmetry observed regions nondyslexic subjects reading, pattern more symmetric. These...
Abstract To investigate local metabolic and hemodynamic interrelationships during functional activation of the brain, paired studies cerebral glucose utilization (lCMRGlc) blood flow (lCBF) were carried out in 10 normal subjects (9 right‐handed, 1 ambidextrous) at rest a unilateral discriminative somatosensory/motor task—palpation sorting mah‐jongg tiles by engraved design. The extent was assessed on basis percentage difference images following normalization to compensate for global shifts....
To determine the frequency, distribution, and clinical features of Parkinson disease (PD) with PINK1 mutations.Retrospective genetic review.University hospital.We performed extensive mutation analyses in 414 PD patients negative for parkin mutations (mean [SD] age at onset, 42.8 [14.3] years), including 391 unrelated (190 sporadic 201 probands familial PD) from 13 countries.We found 10 9 families identified 7 novel (2 homozygous [p.D297MfsX22 p.W437R] 5 single heterozygous [p.A78V,...
The Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease (PD) Rating Scale (UPDRS) (MDS-UPDRS) has been developed and is now available in English. Part overall program includes establishment official non-English translations MDS-UPDRS. We present process for completing Japanese translation MDS-UPDRS with clinimetric testing results.In this trial, was translated into Japanese, underwent cognitive pre-testing, modified after taking results account. final...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by selective loss of motor neurons in the brain and spinal cord. Multiple toxicity pathways, such as oxidative stress, misfolded protein accumulation, dysfunctional autophagy, are implicated pathogenesis ALS. However, molecular basis interplay between multiple factors vivo remains unclear. Here, we report that two independent ALS-linked autophagy-associated gene products; SQSTM1/p62 ALS2/alsin, but not...
Background Rapid eye movement sleep behavior disorder (RBD) and olfactory dysfunction are useful for early diagnosis of Parkinson’s disease (PD). RBD severe also regarded as risk factors cognitive impairment in PD. This study aimed to assess the associations between RBD, function, clinical symptoms patients with Methods The participants were 404 non-demented Probable (pRBD) was determined using Japanese version screening questionnaire (RBDSQ-J) Single-Question Screen (RBD1Q). Olfactory...
Various postural deformities appear during progression of Parkinson's disease (PD), but the underlying pathophysiology these is not well understood. The angle abnormalities seen in individual patients may be due to distinct causes, rather they have occurred an interrelated manner maintain a balanced posture.We measured neck flexion (NF), fore-bent (FB), knee-bent (KB) and lateral-bent (LB) angles 120 PD patients, examined their mutual relationships, correlations with clinical predictors such...
The present multicenter cross-sectional study was performed using semistructured questionnaires to determine the contributing factors of sleep disturbances in Japanese patients with Parkinson's disease (PD). We used scale (PDSS, version). All data were obtained by means interviewed questionnaire and physical examination neurologists. carried out between April 2005 December at eight university hospitals affiliated facilities Kanto area Japan. A total 188 (85 men 103 women) PD 144 controls (64...
The objective of this multicenter cross-sectional study was to determine the prevalence fatigue and factors contributing it in a large sample Japanese patients with Parkinson's disease (PD). We used 16-item Parkinson Fatigue Scale (PFS-16), which designed assess exclusively associated PD. carried out using PFS-16, Unified Disease Rating Scale, Zung's Self-Rating Depression Sleep (PDSS), PD quality life (QOL) scale (PDQ-39) by interview questionnaires physical examination neurologists 361...
Twenty subjects with mildly to moderately severe Alzheimer disease (AD) and 14 normal elderly control were studied using [ 18 F]fluorodeoxyglucose positron emission tomography (PET) investigate regional cerebral glucose metabolism during both a resting state behavioral activation state, utilizing reading memory task (RMT). The RMT produced significant global metabolic of 15 ± 15% in 11 13% AD subjects. occipital regions preferentially activated, but all groups also significantly activated....
We used positron emission tomography to study normal patterns of local cortical metabolic activation induced by somatosensory stimuli. Palpation and sorting mah-jongg tiles textured design increased glucose rate (ICMRgl), 18% on average, in contralateral cortex. A graphesthesia task gave a similar result. In contrast, vigorous vibrotactile stimulation fingers, face, or knee did not produce consistent focus activation. Our results indicate that ICMRgl is best achieved tasks requiring an...
Objective Bromocriptine mesylate (BRC), a dopamine D2 receptor agonist has been shown to confer neuroprotection, sustained motor function and slowed disease progression in mouse models of amyotrophic lateral sclerosis (ALS) Here we report first human trial ALS. Design A multicenter, Riluzole add-on, randomized, double-blind, placebo controlled 102-week extension BRC clinical trial. Methods The was conducted between January 2009 March 2012 on 36 Japanese ALS patients. 12-week treatment with...