A5004797343- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Sleep and Wakefulness Research
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Virus-based gene therapy research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Dementia and Cognitive Impairment Research
- Sleep and related disorders
- Medical Imaging and Analysis
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Intensive Care Unit Cognitive Disorders
- Immunotherapy and Immune Responses
- LGBTQ Health, Identity, and Policy
- Genetic Neurodegenerative Diseases
- Advanced Neural Network Applications
- RNA Interference and Gene Delivery
University of Cologne
2020-2024
University Hospital Cologne
2020-2024
Charité - Universitätsmedizin Berlin
2009
Importance Deep brain stimulation of the subthalamic nucleus (STN-DBS) improves quality life (QOL) in patients with advanced Parkinson disease (PD). However, controlled studies more than 3 years follow-up are lacking. Objective To investigate long-term effects STN-DBS on QOL compared standard-of-care medication (MED). Design, Setting, and Participants In this prospective, observational, quasi-experimental, longitudinal nonrandomized trial, 183 were screened for eligibility 167 enrolled from...
Previous studies have shown less access to deep brain stimulation (DBS) for Parkinson's disease (PD) in women compared men raising concerns about a potential gender gap resulting from nonclinical factors or differences clinical efficacy postoperative quality of life (QoL), motor, and nonmotor symptoms (NMS) outcomes. This was cross-sectional longitudinal, prospective, observational, controlled, quasi-experimental, international multicenter study. A total sample size 505 consisted 316...
Objective To examine 36-month effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on non-motor symptoms (NMS) compared with standard-of-care medical treatment (MED) in Parkinson’s disease (PD). Methods Here we report the follow-up a prospective, observational, controlled, international multicentre study NILS cohort. Assessments included NMSScale (NMSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes PD (SCOPA)-motor examination, -activities daily living, and...
BackgroundSubthalamic (STN) and pallidal (GPi) deep brain stimulation (DBS) improve quality of life, motor, nonmotor symptoms (NMS) in advanced Parkinson's disease (PD). However, few studies have compared their effects.ObjectiveTo compare effects STN-DBS GPi-DBS.MethodsIn this prospective, observational, multicenter study including 60 PD patients undergoing bilateral (n = 40) or GPi-DBS 20), we examined PDQuestionnaire (PDQ), NMSScale (NMSS), Unified Rating Scale-activities daily living,...
Abstract To identify predictors of 36-month follow-up quality life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes (SCOPA)-motor examination, -activities daily...
Abstract: Cognitive impairment is a prominent symptom of the post-COVID syndrome (PCS). However, correspondence between subjective cognitive complaints (SCC) and objective results inconsistent. Here, we investigated this discrepancy. This longitudinal study included N = 42 individuals who reported SCC as PCS after mild infection at inclusion. Data collection comprised questionnaires neuropsychological assessment baseline follow-up (FU). At FU – on average 15 months acute COVID-19 88 %...
Abstract Some people infected with SARS-CoV-2 report persisting symptoms following acute infection. If these persist for over three months, they are classified as post-COVID-19 syndrome (PCS). Although PCS is frequently reported, detailed longitudinal neuropsychological characterization remains scarce. We aimed to describe the trajectory of cognitive and neuropsychiatric symptoms. 42 individuals deficits after asymptomatic mild/moderate COVID-19 at study inclusion received assessment...
Background: Sleep disturbances and neuropsychiatric symptoms are some of the most common nonmotor in Parkinson’s disease (PD). The effect subthalamic stimulation (STN-DBS) on these beyond a short-term follow-up is unclear. Objective: To examine 36-month effects bilateral STN-DBS quality sleep, depression, anxiety, life (QoL) compared to standard-of-care medical therapy (MED) PD. Methods: In this prospective, controlled, observational, propensity score matched, international multicenter...
Abstract Background Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson’s disease (PD). However, the long-term effects STN-DBS on its relationship with QoL outcome are unclear. Methods In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes PD-motor examination, -activities daily living,...
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) cohorts have provided insights into the earliest neurodegenerative processes in α‐synucleinopathies. Even though polysomnography (PSG) remains gold standard for diagnosis, an accurate questionnaire‐based algorithm to identify eligible subjects could facilitate efficient recruitment research. Objective This study aimed optimize identification of with iRBD from general population. Methods Between June 2020 and...
Abstract The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s disease (PD) are understudied. We identified clinical predictors STN-DBS this study. In prospective, open-label, multicentre study, we assessed patients with undergoing for PD preoperatively and at 6-month follow-up postoperatively. the Hospital Anxiety Depression Scale (HADS-anxiety depression subscales), Unified Rating Scale-motor examination, Scales Outcomes PD-motor (SCOPA-M)-activities...
The effects of subthalamic stimulation (subthalamic nucleus-deep brain stimulation, STN-DBS) on impulsive and compulsive behaviours (ICB) in Parkinson's disease (PD) are understudied.To investigate clinical predictors STN-DBS ICB.In this prospective, open-label, multicentre study patients with PD undergoing bilateral STN-DBS, we assessed preoperatively at 6-month follow-up postoperatively. Clinical scales included the Questionnaire for Impulsive-Compulsive Disorders PD-Rating Scale...
Abstract Background While subthalamic nucleus deep brain stimulation (STN-DBS) improves the quality of life (QoL) patients with Parkinson’s disease (PD), clinical parameters that predict this improvement remain debated. This retrospective study explored whether preoperative motor, cognitive, and affective QoL or its components at 6 12 months after STN-DBS surgery. Methods was assessed Disease Questionnaire-39 (PDQ-39) before (baseline), (N = 90) 63) Changes in PDQ-39 subdomains were analysed...
Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson’s disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for prediction outcomes limited, we sought investigate association between voxel-based morphometry short-term following STN-DBS this prospective...
Background Subthalamic nucleus deep brain stimulation (STN-DBS) for Parkinson’s disease (PD) improves quality of life (QoL), motor and non-motor symptoms (NMS). However, in previous studies, 43%–49% patients did not experience clinically relevant postoperative QoL improvement. To inform individualised prediction improvement, we developed a stratification analysis outcomes based on preoperative total burden, severity progression response levodopa challenge tests. Methods This was prospective,...
The new essential tremor (ET) classification defined ET-plus (ET-p) as an ET subgroup with additional neurological signs besides action tremor. While deep brain stimulation (DBS) is effective in ET, there are no studies specifically addressing DBS effects ET-p. 44 patients medication-refractory and thalamic/subthalamic implanted at our center were postoperatively classified into ET-p according to preoperative documentation. Tremor suppression (stimulation ON vs. baseline OFF), measured via...
Background: Stigma is a relevant aspect of Parkinson’s disease (PD). Specific stigma tools are needed to address the complex construct in PD comprehensively. Objective: To test dimensionality and psychometric properties newly developed Disease Questionnaire (PDStigmaQuest). Methods: In this multi-center, cross-sectional study including patients healthy controls, PDStigmaQuest was examined through exploratory factor analysis. Acceptability were investigated. scores controls compared. Results:...
The high mortality of melanoma demands the development new strategies, and gene therapy may be considered provided improvements in efficacy selectivity. Overexpression death ligand CD95L/FasL has been shown previous studies as highly effective for apoptosis induction cells. For efficient selective targeting melanoma, a conditional replication-competent adenoviral vector was constructed (Ad5-FFE-02), which drives CD95L expression by tetracycline-inducible promoter. restricting its replication...
The satisfaction with life and, in particular, treatment Parkinson's disease (PD) is understudied.To explore a new 7-item rating tool assessing and (SLTS-7) PD.In this cross-sectional, multi-center study, including patients screened for advanced therapies, psychometric characteristics of the SLTS-7 were analyzed. An exploratory factor analysis identified underlying factorial structure SLTS-7.117 included, data quality was excellent (computable 100%), acceptability measures satisfied standard...
The effect of subthalamic stimulation (STN-DBS) on patients’ personal satisfaction with life and their Parkinson’s disease (PD) treatment is understudied, as its correlation quality (QoL). Therefore, we tested the hypothesis that STN-DBS for PD enhances treatment. In a prospective, multicenter study 6-month follow-up involving 121 patients, measured main outcomes using Satisfaction Life Treatment Scale (SLTS-7). Secondary included eight-item Questionnaire (PDQ-8), European QoL (EQ-5D-3L),...