A5056969461- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Neurological diseases and metabolism
- Transcranial Magnetic Stimulation Studies
- Neurological and metabolic disorders
- Autism Spectrum Disorder Research
- Balance, Gait, and Falls Prevention
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Ginkgo biloba and Cashew Applications
- Cerebral Palsy and Movement Disorders
- RNA regulation and disease
- Olfactory and Sensory Function Studies
- Parkinson's Disease and Spinal Disorders
- Sleep and Wakefulness Research
- Glycogen Storage Diseases and Myoclonus
- Attention Deficit Hyperactivity Disorder
- Alzheimer's disease research and treatments
- Dysphagia Assessment and Management
- Advanced Neuroimaging Techniques and Applications
- Hereditary Neurological Disorders
- Neuroscience and Neuropharmacology Research
Seoul National University Hospital
2016-2025
Seoul National University
2015-2024
Chung-Ang University Hospital
2021-2024
Chung-Ang University
2024
Seoul National University Bundang Hospital
2007-2024
Ajou University
2024
Weatherford College
2024
University of Iowa
2024
Ewha Womans University
2016-2023
Chungnam National University
2023
<b>Objective: </b> α-Synuclein gene (<i>SNCA</i>) multiplication was found in familial Parkinson disease (PD). We examined <i>SNCA</i> patients with and sporadic PD multiple system atrophy (MSA). <b>Methods: screened 1,106 parkinsonism (PD = 906, MSA 200) for by multiplex PCR. Fluorescent situ hybridization done to confirm the multiplication. [<sup>123</sup>I]<i>N</i>-ω-Fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)-tropane ([<sup>123</sup>I]FP-CIT) SPECT their family members. <b>Results:...
Although there is clinical demand for new technology that can accurately measure Parkinsonian tremors, automatic scoring of tremors using machine-learning approaches has not yet been employed. This study aims to fill this gap by proposing algorithms as a way predict the Unified Parkinson's Disease Rating Scale (UPDRS), which are similar how neurologists rate scores in actual practice. In study, tremor signals 85 patients with disease (PD) were measured wrist-watch-type wearable device...
Chronic alpha-synuclein (SNCA) overexpression is a relatively homogenous and well-defined cause of parkinsonism dementia. Parkinson's disease (PD), PD with dementia, dementia Lewy bodies multiple system atrophy all manifest in SNCA multiplication families. Herein we summarize genealogic, clinical genetic data from 59 families (25 not previously published) caused by multiplications. Longitudinal assessments genealogic relationships were documented for family members. All probands genotyped an...
<h3>Objective</h3> To analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD). <h3>Methods</h3> Forty-nine patients with PD 54 age-matched controls were analyzed. Ophthalmologic examination macula optical coherence tomography scans performed additional microperimetry, <i>N</i>-(3-[<sup>18</sup>F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane PET, 3T MRI done only. Retinal layer thickness volume measured subfields of 1-,...
Abstract Botulinum toxin (BT) therapy is a complex and highly individualised defined by treatment algorithms injection schemes describing its target muscles their dosing. Various consensus guidelines have tried to standardise improve BT therapy. We wanted update by: (1) Acknowledging recent advances of algorithms. (2) Basing dosing tables on statistical analyses real-life data 1831 injections in 36 different 420 dystonia patients 1593 31 240 spasticity patients. (3) Providing more detailed...
Abstract The International Parkinson and Movement Disorder Society (MDS) created a task force (TF) to provide critical overview of the Parkinson's disease (PD) subtyping field develop guidance on future research in PD subtypes. Based literature review, we previously concluded that requires an ultimate alignment with principles precision medicine, consequently novel approaches were needed describe heterogeneity at individual patient level. In this manuscript, present purpose‐driven framework...
To determine whether CSF biomarkers can be used as a predictor of freezing gait (FOG) in Parkinson disease (PD) and to investigate the predictive value clinical, dopamine transporter (DAT) imaging, parameters both separately combination.This study using PPMI data included 393 patients with newly diagnosed PD without FOG at baseline. We evaluated for β-amyloid 1-42 (Aβ42), α-synuclein, total tau, phosphorylated tau181, calculated ratio Aβ42 tau Demographic clinical DAT imaging results were...
<h3>Background and Objectives</h3> Mild cognitive impairment (MCI) in isolated REM sleep behavior disorder (iRBD) is a risk factor for subsequent neurodegeneration. We aimed to identify brain metabolism functional connectivity changes related MCI patients with iRBD the neuroimaging markers9 predictive value phenoconversion. <h3>Methods</h3> This prospective cohort study of mean follow-up 4.2 ± 2.6 years. At baseline, age- sex-matched healthy controls (HCs) underwent...
Parkinson's disease is a neurodegenerative disorder with multifactorial aetiology. Nevertheless, the genetic predisposition in many families multi-incidence remains unknown. This study aimed to identify novel genes that cause familial disease. Whole exome sequencing was performed three affected members of index family late-onset autosomal-dominant parkinsonism and polyneuropathy. We identified heterozygous substitution c.941A>C (p.Tyr314Ser) mitochondrial ubiquinol-cytochrome c reductase...
Purpose To examine whether the loss of nigral hyperintensity (NH) on 3.0-T susceptibility-weighted (SW) magnetic resonance (MR) images can help identify high synucleinopathy risk in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Materials and Methods Between March 2014 April 2015, 18 consecutively recruited iRBD were evaluated SW imaging iodine 123–2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) single photon emission computed...