A5101529509- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Microtubule and mitosis dynamics
- Renal Diseases and Glomerulopathies
- Diverse Approaches in Healthcare and Education Studies
- Botulinum Toxin and Related Neurological Disorders
- Food Quality and Safety Studies
- CRISPR and Genetic Engineering
- Ginseng Biological Effects and Applications
- Animal Genetics and Reproduction
- Plant Molecular Biology Research
- Chromosomal and Genetic Variations
- Advanced biosensing and bioanalysis techniques
- Genetic Neurodegenerative Diseases
- Agriculture, Soil, Plant Science
- Education, Safety, and Science Studies
- Ubiquitin and proteasome pathways
- Glutathione Transferases and Polymorphisms
- Chronic Kidney Disease and Diabetes
- Lipid metabolism and disorders
- Effects and risks of endocrine disrupting chemicals
- GABA and Rice Research
- Histone Deacetylase Inhibitors Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Health and Wellbeing Research
Seoul National University Hospital
2014-2023
Sunrise Medical (United States)
2023
ABL Bio (South Korea)
2021-2022
Target (United States)
2022
Institute of Crop Science
2021
Yonsei University
2007-2021
Sungkyunkwan University
2006-2020
Samsung (South Korea)
2006-2020
Dong-Eui University
2019
Kyungpook National University Hospital
2018-2019
Although there is clinical demand for new technology that can accurately measure Parkinsonian tremors, automatic scoring of tremors using machine-learning approaches has not yet been employed. This study aims to fill this gap by proposing algorithms as a way predict the Unified Parkinson's Disease Rating Scale (UPDRS), which are similar how neurologists rate scores in actual practice. In study, tremor signals 85 patients with disease (PD) were measured wrist-watch-type wearable device...
Several preclinical studies demonstrate that antitumor efficacy of programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade can be improved by combination with other checkpoint inhibitors. Lymphocyte-activation gene 3 (LAG-3) is an inhibitory receptor involved in T exhaustion and tumor immune escape. Here, we describe ABL501, a bispecific antibody targeting LAG-3 PD-L1 modulating responses against tumors. ABL501 efficiently inhibits both pathways enhances the activation effector CD4
Pain is a common and distressing feature in Parkinson disease (PD). The major indication of subthalamic nucleus deep brain stimulation (STN DBS) motor complications advanced PD; however, pain reduction after STN DBS has been noted.To evaluate the long-term effect on PD.Twenty-four patients who underwent at Movement Disorder Center Seoul National University Hospital from June 1, 2005, through March 31, 2006, were studied. assessments performed preoperatively 8 years surgery. Because 13 total...
Freezing of gait (FOG) is a common motor impairment to suffer an inability walk, experienced by Parkinson's disease (PD) patients. FOG interferes with daily activities and increases fall risk, which can cause severe health problems. We propose novel smartphone-based system detect symptoms in unconstrained way. The feasibility single device sense characteristic was tested on the various body positions such as ankle, trouser pocket, waist chest pocket. Using measured data from accelerometer...
ABSTRACT Swine wastewater is not easily treated in biological treatment plants. One reason that some antibiotics are degradable a normal system and inhibit the organisms system. Specifically, tetracycline, sulfathiazole, ampicillin representative found poultry wastewater. To degrade these refractory impediment more easily, special method needed, such as an enzyme method. This research used experiment tested feasibility with assay of vitro. The Glutathion S-Transferases (GSTs) family proteins...
To examine the prevalence of mutations in spinocerebellar ataxia (SCA) genes patients who were clinically diagnosed with multiple system atrophy (MSA).Genetic tests for SCA performed 302 528 met diagnostic criteria MSA based on clinical features. Generally, when a patient had cerebellar symptoms or neuroimaging, genetic types 1, 2, 3, 6, 7, and 17, dentatorubropallidoluysian done, parkinsonism without symptoms, 17 done.Mutations found 22 (7.3%) SCA17 comprising more than half...
Although clinical aspirations for new technology to accurately measure and diagnose Parkinsonian tremors exist, automatic scoring of tremor severity using machine learning approaches has not yet been employed.This study aims maximize the scientific validity tremor-severity classification algorithms score in same manner as unified Parkinson's disease rating scale (UPDRS) used rate scores real practice.Eighty-five PD patients perform four tasks assessment their resting, resting with mental...
Abstract Background Gene fusions have been studied extensively, as frequent drivers of tumorigenesis well potential therapeutic targets. In many well-known cases, breakpoints occur at two intragenic positions, leading to in-frame gene-gene that generate chimeric mRNAs. However, often with intergenic breakpoints, and the role such has not carefully examined. Results We analyze whole-genome sequencing data from 268 patients catalog gene-intergenic intergenic-intergenic characterize their...
Di(2-ethylhexyl) phthalate (DEHP) is a well-known hepatic and reproductive toxicant whose toxicity may be mediated by peroxisome proliferators-activated receptor (PPAR). This study examined the effects of DEHP on expression PPAR-regulated genes involved in testicular cells apoptosis. Sprague-Dawley male rats were treated orally with 250, 500, or 750 mg/kg/d for 28 d, while control given corn oil. The levels cell cycle regulators (pRb, cyclins, CDKs, p21) apoptosis-related proteins analyzed...
Subthalamic nucleus deep brain stimulation (STN DBS) is effective against freezing of gait (FOG) in Parkinson's disease (PD); however, whether this effect persists over the long term debated. The aim current study was to investigate long-term STN DBS on FOG patients with PD.
The BubR1 mitotic-checkpoint protein monitors proper attachment of microtubules to kinetochores, and links regulation chromosome-spindle signaling. Thus, disruption activity results in a loss checkpoint control, chromosomal instability caused by premature anaphase, and/or the early onset tumorigenesis. mechanisms which deregulation abnormalities expression operate, however, remain be elucidated. In this study, we demonstrate that levels are significantly increased demethylation. Bisulfite...
Peptide nucleic acids (PNAs) are mimics of oligonucleotides containing a neutral peptidelike backbone and able to bind complementary DNA targets with high affinity selectivity. In order investigate the effect ionic strength buffer solution, hybridization experiments PNAs as (catcher) probes DNAs target were performed in different salt solutions. Surface plasmon field-enhanced fluorescence spectroscopy was employed for real-time monitoring hybridizations surface bound PNA. Probes three strand...
The cellular susceptibility of cancer cells to histone deacetylase (HDAC) inhibitors is increased by the etopic expression oncogenic Ras. However, ability HDAC regulate apoptotic pathway in human breast still not completely understood. In this study, anti-proliferative effects apicidin were compared H-ras-transformed epithelial (MCF10A-ras) and non-transformed (MCF10A) cells. MCF10A-ras showed a significantly higher growth rate than MCF10A Apicidin levels acetylated H3 H4 both cell lines....