A5019341907- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neurological and metabolic disorders
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Mitochondrial Function and Pathology
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
- Autoimmune Neurological Disorders and Treatments
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- Cerebrovascular and Carotid Artery Diseases
- Lysosomal Storage Disorders Research
- Acute Ischemic Stroke Management
- Voice and Speech Disorders
- Hereditary Neurological Disorders
- Dysphagia Assessment and Management
- Neurological diseases and metabolism
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Alcoholism and Thiamine Deficiency
- Child Nutrition and Feeding Issues
Eulji University
2016-2025
Hallym University Sacred Heart Hospital
2020-2023
Pfizer (Canada)
2022
BioNTech (United States)
2022
Eulji General Hospital
2015-2019
Seoul National University Hospital
2009-2017
Myongji Hospital
2014
Seoul National University
2009-2014
Kyung Hee University Hospital at Gangdong
2014
Parkinson's disease (PD) is characterized by various prodromal symptoms, and these symptoms are mostly investigated retrospectively. While some such as rapid eye movement sleep behavior disorder highly specific, others common. This makes it challenging to predict those at risk of PD based solely on less-specific symptoms. The prediction accuracy when using only can be improved analyzing the vast amount information available sophisticated deep-learning techniques. study aimed improve...
Although there is clinical demand for new technology that can accurately measure Parkinsonian tremors, automatic scoring of tremors using machine-learning approaches has not yet been employed. This study aims to fill this gap by proposing algorithms as a way predict the Unified Parkinson's Disease Rating Scale (UPDRS), which are similar how neurologists rate scores in actual practice. In study, tremor signals 85 patients with disease (PD) were measured wrist-watch-type wearable device...
Pain is a common and distressing feature in Parkinson disease (PD). The major indication of subthalamic nucleus deep brain stimulation (STN DBS) motor complications advanced PD; however, pain reduction after STN DBS has been noted.To evaluate the long-term effect on PD.Twenty-four patients who underwent at Movement Disorder Center Seoul National University Hospital from June 1, 2005, through March 31, 2006, were studied. assessments performed preoperatively 8 years surgery. Because 13 total...
To examine the prevalence of mutations in spinocerebellar ataxia (SCA) genes patients who were clinically diagnosed with multiple system atrophy (MSA).Genetic tests for SCA performed 302 528 met diagnostic criteria MSA based on clinical features. Generally, when a patient had cerebellar symptoms or neuroimaging, genetic types 1, 2, 3, 6, 7, and 17, dentatorubropallidoluysian done, parkinsonism without symptoms, 17 done.Mutations found 22 (7.3%) SCA17 comprising more than half...
Although clinical aspirations for new technology to accurately measure and diagnose Parkinsonian tremors exist, automatic scoring of tremor severity using machine learning approaches has not yet been employed.This study aims maximize the scientific validity tremor-severity classification algorithms score in same manner as unified Parkinson's disease rating scale (UPDRS) used rate scores real practice.Eighty-five PD patients perform four tasks assessment their resting, resting with mental...
Previously, we defined DRD as a syndrome of selective nigrostriatal dopamine deficiency caused by genetic defects in the synthetic pathway without nigral cell loss.DRD-plus also has same etiologic background with DRD, but DRD-plus patients have more severe features that are not seen because severity defect.However, there been many reports dystonia responsive to dopaminergic drugs do fit into or (genetic loss).We reframed concept DRD/DRD-plus and proposed look-alike include additional cases...
Tuberculous meningitis (TBM) is fatal unless treated promptly. Nonconvulsive status epilepticus (NCSE) may cause altered consciousness in patients with TBM. A 25-year-old female presented to the emergency department a headache and fever along multiple associated symptoms that had developed 2 days prior. Based on clinical findings, brain imaging, cerebrospinal fluid (CSF) examination, she was tentatively diagnosed viral meningitis. Later, focal seizures, follow-up CSF examination findings...
Abstract The diagnosis of multiple system atrophy (MSA) is mainly based on the clinical criteria, which are often little assistance in early stages disease. Positional downbeat nystagmus (pDBN) and perverted head‐shaking (pHSN), possible signs cerebellar dysfunction, may be useful differentiating MSA from other parkinsonian disorders. To investigate occurrences pDBN pHSN patients with compared those Parkinson's disease (PD). A total 127 consecutive 274 PD underwent a video‐oculographic...
Dysphagia, a symptom of multiple system atrophy (MSA), is major clinical concern. In this study, we investigate the characteristics early oropharyngeal dysphagia (OD) in patients with MSA, and differences between MSA subtypes.Patients enrolled study had previously been diagnosed at clinic Department Neurology, referred for videofluoroscopic swallowing (VFSS), 2005 2014, to check dysphagia. The VFSS findings were analyzed compared subtypes.This 59 (24 men; 31 MSA-P, 21 MSA-C, 7 MSA-PC)....
We investigated the effect of propofol and fentanyl on microelectrode recording (MER) its clinical applicability during subthalamic nucleus (STN) deep brain stimulation (DBS) surgery. analyzed 8 patients with Parkinson's disease, underwent bilateral STN DBS MER. Their left sides were done under awake then their right a continuous infusion local anesthesia. The electrode position was evaluated by preoperative MRI postoperative CT. outcomes assessed at six months after isolated single unit...
<b><i>Background and Objectives:</i></b> The incidence of visual hallucination (VH) increases with Parkinson's disease (PD) progression, its development is thought to be related a specific neurodegenerative process in PD. This study aimed reveal brain degeneration VH PD by analyzing neuroimaging data obtained from patients their different stages <b><i>Methods:</i></b> Data 48 - 21 nondemented without (PNV group), 10 (PV 17 demented (PVD group)...
Background GPi (Internal globus pallidus) DBS (deep brain stimulation) is recognized as a safe, reliable, reversible and adjustable treatment in patients with medically refractory dystonia. Objectives This report describes the long-term clinical outcome of 36 implanted at Neurosurgery Department Seoul National University Hospital. Methods Nine known genetic cause, 12 acquired dystonia, 15 isolated dystonia without cause were included. When categorized by phenomenology, 29 had generalized, 5...
It is challenging to detect Parkinson's disease (PD) in its early stages, which has prompted researchers develop techniques based on machine learning methods for detecting PD. However, previous studies did not fully incorporate the slow progression of PD over a long period time nor consider that symptoms occur time-sequential manner. Contributing literature PD, relied heavily cross-sectional data, this study aimed method can process time-series information using short-term memory (LSTM)...
Awakening during deep brain stimulation (DBS) surgery may be stressful to patients. The aim of the current study was evaluate effect on MER signals and their applicability subthalmic nucleus (STN) DBS for patients with Parkinson's disease (PD) under sedation propofol fentanyl. Sixteen consecutive PD underwent STN-DBS Their were achieved surgery. To identify microelectrodes positions, preoperative MRI postoperative CT used. Clinical profiles also collected at baseline 6 months after All...
We examined whether amantadine can prevent the development of dyskinesia.Patients with drug-naïve Parkinson's disease (PD), younger than 70 years age and in early stage PD (Hoehn Yahr scale < 3), were recruited from April 2011 to December 2014. The exclusion criteria included previous use antiparkinsonian medication, presence dyskinesia, significant psychological disorders, history a hypersensitivity reaction. Patients consecutively assigned one 3 treatment groups an open label fashion:...