A5103240519- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Restless Legs Syndrome Research
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Treatments and Mutations
- Mind wandering and attention
- Impact of Technology on Adolescents
- Neuroscience and Neuropharmacology Research
- Ginkgo biloba and Cashew Applications
- Atrial Fibrillation Management and Outcomes
- Genetic Neurodegenerative Diseases
- Neurobiology of Language and Bilingualism
- Musculoskeletal pain and rehabilitation
- Lung Cancer Diagnosis and Treatment
- Retinal Development and Disorders
- Ophthalmology and Eye Disorders
- Cardiac Arrhythmias and Treatments
Boramae Medical Center
2014-2025
Seoul National University
2012-2025
Seoul Metropolitan Government
2013-2025
Kyung Hee University
2022
New Generation University College
2010-2021
Seoul National University Hospital
2011-2021
University of Calgary
2019-2021
Ontario Brain Institute
2020-2021
National University College
2018-2021
Institut Universitaire de Gériatrie de Montréal
2019
<h3>Objective</h3> To analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD). <h3>Methods</h3> Forty-nine patients with PD 54 age-matched controls were analyzed. Ophthalmologic examination macula optical coherence tomography scans performed additional microperimetry, <i>N</i>-(3-[<sup>18</sup>F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane PET, 3T MRI done only. Retinal layer thickness volume measured subfields of 1-,...
Abstract To investigate the clinical impact of mild behavioral impairment (MBI) in a predefined cohort with Lewy body disease (LBD) continuum. Eighty-four patients LBD continuum participated this study, including 35 video-polysomnography-confirmed idiopathic REM sleep behavior disorder (iRBD) and 49 clinically established LBD. Evaluations included Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), neuropsychological tests, MBI Checklist (MBI-C). We examined...
Internet game overuse is an emerging disorder and features diminished impulse control poor reward-processing. In attempt to understand the neurobiological bases of overuse, we investigated differences in regional cerebral glucose metabolism at resting state between young individuals with those normal use using 18F-fluorodeoxyglucose positron emission tomography study.Twenty right-handed male participants (9 users: 24.7+/-2.4 years age, 11 overusers: 23.5+/-2.9 age) participated. A trait...
It is suggested that transcranial direct current stimulation (tDCS) can produce lasting changes in corticospinal excitability and potentially be used for the treatment of neuropathic pain. However, detailed mechanisms underlying effects tDCS are unknown.We investigated neural chronic pain relief using [(18)F]-fluorodeoxyglucose positron emission tomography ([(18)F]FDG-PET).Sixteen patients with (mean age 44.1 ± 8.6 years, 4 females) due to traumatic spinal cord injury received sham or active...
To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns gray matter changes in Parkinson disease (PD).Sixty patients PD without dementia 29 healthy controls underwent a neuropsychological evaluation structural MRI scan. MBI was evaluated Checklist (MBI-C), rating scale designed to elicit emergent neuropsychiatric symptoms accordance criteria. We divided into 2 groups: 1 group high MBI-C scores (PD-MBI) other low (PD-noMBI).Among 60 PD, 20 were...
Background Mild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by later life emergence of sustained neuropsychiatric symptoms, as an at-risk state for dementia. However, the associations between MBI and risk progression to Alzheimer’s disease (AD) its neuroanatomical correlates in mild cognitive (MCI) are still unclear. Method A total 1,184 older adults with amnestic MCI was followed mean 3.1 ± 2.0 years. approximated using transformation algorithm Neuropsychiatric...
<h3>Background and Objectives</h3> Mild cognitive impairment (MCI) in isolated REM sleep behavior disorder (iRBD) is a risk factor for subsequent neurodegeneration. We aimed to identify brain metabolism functional connectivity changes related MCI patients with iRBD the neuroimaging markers9 predictive value phenoconversion. <h3>Methods</h3> This prospective cohort study of mean follow-up 4.2 ± 2.6 years. At baseline, age- sex-matched healthy controls (HCs) underwent...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the degeneration of motor neurons. Mutations in Cu/Zn superoxide dismutase (SOD1), including G93A, were reportedly linked to familial ALS. SOD1 key antioxidant enzyme, and also one major targets for oxidative damage brains patients suffering from Alzheimer's (AD). Several lines evidence suggest that intracellular amyloid beta (Aβ) associated with pathogenesis AD. In this report we demonstrate Aβ directly interacts...
Abstract Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, personality characteristics with alcohol use (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve clear understanding of the neurobiological features IGD, we aimed identify morphological functional changes in compare them those Individuals showed larger volume hippocampus/amygdala precuneus than healthy...
ABSTRACT Introduction Defective visual information processing contributes to hallucination in PD, for which “top‐down” and “bottom‐up” impairment are suggested mechanisms. This study was aimed investigate macro‐ microstructural neural changes afferent pathways relation nondemented PD patients. Methods included 24 nondemented, nondepressed patients (10 hallucinating 14 nonhallucinating) 15 age‐matched healthy controls. We analyzed volumetric diffusion tensor MRI data by applying region of...
Mild behavioral impairment (MBI) is a syndrome characterized by later life onset, sustained neuropsychiatric symptoms as marker of dementia risk. In Parkinson's disease (PD), MBI has been associated with worse cognitive abilities and increased cortical atrophy. However, the circuit level correlates have not investigated in this population. Our objective was to investigate relationship between corticostriatal connectivity PD patients. This emphasis on due significant role these circuits...
It remains unclear whether and how the isolated rapid eye movement (REM) sleep behavior disorder (iRBD)-related metabolic pattern (RBDRP) changes with disease progression in iRBD.To examine longitudinal RBDRP expression iRBD patients to explore trajectories of relative activities individual brain regions constituting RBDRP.In this cohort study, 25 (mean age [±standard deviation], 69.2 ± 5.3 years; 12 [48%] were men) 24 age-matched healthy controls included. The underwent at least two 18...
<h3>Objective</h3> To elucidate the role of Parkinson disease (PD)-related brain metabolic patterns as a biomarker in isolated REM sleep behavior disorder (iRBD) for future conversion. <h3>Methods</h3> This is prospective cohort study consisting 30 patients with iRBD, 25 de novo PD premorbid history RBD, 21 longstanding on stable treatment, and 24 healthy controls. The iRBD group was longitudinally followed up. All participants underwent <sup>18</sup>F-fluorodeoxyglucose (FDG) PET were...
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson's Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain. We investigated the capability of baseline brain [
Background and PurposeTo identify a metabolic network reflecting neurodegeneration in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD).Methods We recruited prospective cohort comprising de novo Parkinson's disease (PD) probable REM (PDRBD, n=21), polysomnographyconfirmed iRBD (n=28), age-matched healthy controls (HC) (n=24).PDRBD-related spatial covariance pattern (PDRBD-RP) were determined from 18 F-fluorodeoxyglucose PET images of the PDRBD group validated...
Abstract REM sleep behavior disorder (RBD) has a poor prognostic implication in both motor and non-motor functions Parkinson’s disease (PD) patients. However, to the best of our knowledge no study date investigated longitudinal cerebral changes underlying RBD symptoms PD. We performed investigate association between probable cortical subcortical early, de novo PD studied 78 participants from Progression Marker Initiative who underwent structural MRI at baseline after 2 years. The presence...
To investigate structural and functional connectivity changes in brain olfactory-related structures a longitudinal prospective cohort of isolated REM sleep behavior disorder (iRBD) their clinical correlations, evolution, predictive values for phenoconversion to overt synucleinopathies, especially Lewy body diseases.