A5088317967- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Genetic Neurodegenerative Diseases
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Neurobiology of Language and Bilingualism
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Lysosomal Storage Disorders Research
- Cerebral Palsy and Movement Disorders
- Hedgehog Signaling Pathway Studies
- Genetics and Neurodevelopmental Disorders
- Infectious Encephalopathies and Encephalitis
- Genetic and Kidney Cyst Diseases
- Nuclear Receptors and Signaling
- Long-Term Effects of COVID-19
- EEG and Brain-Computer Interfaces
- Infectious Diseases and Tuberculosis
- Bacterial Infections and Vaccines
- Glycogen Storage Diseases and Myoclonus
University of Calgary
2013-2025
University Medical Center
2024
University of Ottawa
2024
University of British Columbia
2024
The University of Texas Southwestern Medical Center
2024
University of Toronto
2024
Ottawa Hospital
2024
Ontario Brain Institute
2019-2021
Canadian Sleep Society
2020
Canadian Thoracic Society
2020
Abstract Niemann Pick disease type C1 (NPC1) is an inherited, autosomal recessive, lipid‐storage disorder with major neurological involvement. Purkinje cell death a prominent feature of the neuropathology NPC. We have investigated in two murine models NPC1, BALB/c npc nih and C57BLKS/J spm . In both cases, extensive was found cerebellum. The pattern complex. First, zebrin II‐negative cells disappear, to leave survivors aligned stripes that closely resemble revealed by using II...
Abstract Transverse boundaries divide the cerebellar cortex into four transverse zones, and within each zone is further subdivided a symmetrical array of parasagittal stripes. Several molecules believed to mediate long‐term depression at parallel fiber–Purkinje cell synapse are known be expressed in We have therefore explored distributions phospholipase Cβ3 Cβ4, key components transduction type 1 metabotropic glutamate receptor‐mediated responses. The data reveal that both Cβ isotypes...
To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns gray matter changes in Parkinson disease (PD).Sixty patients PD without dementia 29 healthy controls underwent a neuropsychological evaluation structural MRI scan. MBI was evaluated Checklist (MBI-C), rating scale designed to elicit emergent neuropsychiatric symptoms accordance criteria. We divided into 2 groups: 1 group high MBI-C scores (PD-MBI) other low (PD-noMBI).Among 60 PD, 20 were...
Abstract Niemann Pick disease is a family of autosomal recessive disorders characterized by cholesterol accumulation. The most common type A/B (NPA/B), resulting from deficient acid sphingomyelinase activity, which leads to sphingomyelin and neuropathology NPA/B includes widespread neuronal degeneration. An knockout mouse model (ASMKO) has been developed the targeted deletion gene. When cerebellar morphology was examined in ASMKO at postnatal day 60 (P60), dramatic pattern longitudinal...
Mild behavioral impairment (MBI) is a syndrome characterized by later life onset, sustained neuropsychiatric symptoms as marker of dementia risk. In Parkinson's disease (PD), MBI has been associated with worse cognitive abilities and increased cortical atrophy. However, the circuit level correlates have not investigated in this population. Our objective was to investigate relationship between corticostriatal connectivity PD patients. This emphasis on due significant role these circuits...
Metronidazole (Flagyl®) is an antimicrobial agent commonly used in clinical practice. Although it generally well tolerated with minimal side effects, there are a host of still under-recognized neurologic complications metronidazole treatment. The following review aimed at summarizing current literature pertaining to metronidazole-induced neurotoxicity including syndromes, neuroradiological findings, prognosis and proposed pathophysiology. Recognition the neurotoxic effects critical as prompt...
The Zfp423/ZNF423 gene encodes a 30-zinc-finger transcription factor involved in key developmental pathways. Although null Zfp423 mutants develop cerebellar malformations, the underlying mechanism remains unknown. ZNF423 mutations are associated with Joubert Syndrome, ciliopathy causing vermis hypoplasia and ataxia. participates DNA-damage response (DDR), raising questions regarding its role as regulator of neural progenitor cell cycle progression development. To characterize vivo function...
The dual syndrome hypothesis of cognitive impairment in PD suggests that two profiles exist with distinct pathological mechanisms and a differential risk for further decline. How these relate to network dysfunction has never been explicitly characterized.First, assess intranetwork functional connectivity while considering global connectivity, second, measures the dysexecutive posterior cortical profiles.Eighty-two subjects idiopathic 37 age-matched controls underwent resting-state MRI...
<title>Abstract</title> <bold>Background: </bold>Persistent motor and vocal tic disorders (PMTD/PVTD) are distinct diagnoses from Tourette syndrome (TS). In both, the threshold for diagnosis is up to age 18, whereas tics infrequently manifest after 12. <bold>Methods:</bold> our cohort of youth with Calgary, Canada, we aimed determine whether clinical features comorbidity profile PMTD/PVTD differ those TS, assess chronic adolescent-onset (age≥12) different childhood-onset (<12yr)....
Background. Gangliosides - glycosphingolipids that modulate cell signaling and neuronal functions are decreased in Huntington disease (HD) models the brain of patients. Restoring ganglioside GM1 has therapeutic benefits HD mice, slowing neurodegeneration improving symptoms. This suggests gangliosides might contribute to pathogenesis. However, their link severity progression patients remains unclear. Objectives. study examined plasma differences between gene carriers controls, prognostic...
Background The neuroplastins np65 and np55 are two synapse-enriched immunoglobulin (Ig) superfamily adhesion molecules that contain 3 2 Ig domains respectively. Np65 is implicated in long term, activity dependent synaptic plasticity, including LTP. regulates the surface expression of GluR1 receptor subunits localisation GABAA subtypes hippocampal neurones. brain not only on glucose but monocarboxylates as sources energy. The. monocarboxylate transporters (MCTs) 1–4 responsible for rapid...
Neuropsychiatric symptoms (NPS) are common in Parkinson's disease (PD) and have demonstrated an association with the p. Val66Met, a polymorphism BDNF gene. Mild behavioral impairment (MBI) is validated syndrome describing emergent persistent NPS older adults as marker of potential cognitive decline dementia. This study investigated if PD patients Met allele were more likely to MBI whether they had impairments specific domains using Behavioral Impairment Checklist (MBI-C) ascertainment tool....
Abstract Purpose/Background Antipsychotics are efficacious for tics and increasingly prescribed to children with behavioral disorders. have important adverse effects, systematic monitoring of drug safety is infrequently performed. The objectives this study were determine the feasibility antipsychotic in Tourette Syndrome using a defined protocol evaluate risk effects chronic use. Methods/Procedures A prospective longitudinal antipsychotics was Children monitored extrapyramidal, metabolic,...
Background: Mild cognitive impairment is a common non-motor symptom of Parkinson's disease (PD-MCI) and has minimal treatment options. Objective: In this double-blind, randomized, sham-controlled trial, we assessed the effect repeated sessions intermittent theta-burst stimulation over left dorsolateral prefrontal cortex on cognition brain connectivity in subjects with PD-MCI. Methods: Forty-one were randomized to receive real ( n = 21) or sham 20). All underwent neuropsychological...
Background and purpose Anxiety depression are common disabling comorbidities in cervical dystonia (CD) may predispose to social withdrawal cognitive impairments. The relationship between cognition depressive/anxiety symptoms CD is under‐investigated. Methods Forty‐six patients (40 women; mean age ± SD, 55.57 10.84 years) were administered the following battery: Affect Naming, Prosody Face Pair Matching subtests from Wechsler Adult Intelligence Scale IV Memory (social perception),...
Abstract Cognitive impairments are prevalent in Parkinson’s disease (PD), but the underlying mechanisms of their development unknown. In this study, we aimed to predict global cognition (GC) PD with machine learning (ML) using structural neuroimaging, genetics and clinical demographic characteristics. As a post-hoc analysis, explore connection between novel selected features GC more precisely investigate whether relationship is specific or driven by cognitive domains. 101 idiopathic patients...
A 54-year-old man presented with a 3-day history of difficulty speaking and an unsteady gait after having generalized tonic-clonic seizure. He had been taking oral metronidazole for bronchiectasis 2 months before presentation (estimated cumulative dose about 60 g). His medical