A5100780461- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Optimal Experimental Design Methods
- Neurological disorders and treatments
- Eosinophilic Disorders and Syndromes
- Influenza Virus Research Studies
- Streptococcal Infections and Treatments
- Medical Research and Treatments
- HIV/AIDS drug development and treatment
- Dementia and Cognitive Impairment Research
- Global Cancer Incidence and Screening
- Growth Hormone and Insulin-like Growth Factors
- Obstructive Sleep Apnea Research
- Animal Disease Management and Epidemiology
- Nicotinic Acetylcholine Receptors Study
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Thermal Regulation in Medicine
- Spine and Intervertebral Disc Pathology
- Cholinesterase and Neurodegenerative Diseases
- Neurofibromatosis and Schwannoma Cases
- Cardiovascular Health and Risk Factors
Guangxi Maternal and Child Health Hospital
2025
China Institute of Veterinary Drug Control
2025
AbbVie (United States)
2015-2024
Peking University Shenzhen Hospital
2023
Alzheimer's Drug Discovery Foundation
2021
Global Alzheimer's Platform Foundation
2021
PLA Navy General Hospital
2008-2016
Harbin Veterinary Research Institute
2014
Northwestern University
2010-2013
Lurie Children's Hospital
2010-2013
Background & AimsAlthough hepatitis C virus (HCV) infection is common in patients with end-stage renal disease, highly efficacious, well-tolerated, direct-acting antiviral regimens have not been extensively studied this population. We investigated the safety and efficacy of ombitasvir co-formulated paritaprevir ritonavir, administered dasabuvir (with or without ribavirin) a prospective study stage 4 5 chronic kidney disease (CKD).MethodsWe performed single-arm, multicenter treatment-naïve...
ABSTRACT Objectives: Eosinophilic esophagitis (EoE) is an immune‐mediated chronic inflammatory disorder triggered by food antigen(s). A 6‐food elimination diet (SFED) excluding cow's milk, soy, wheat, egg, peanuts/tree nuts, and seafood has been shown to induce remission in a majority of children with EoE. The goal the present study was identify specific antigens responsible for eosinophilic esophageal inflammation EoE who had achieved histological SFED. Patients Methods: In this analysis,...
Abstract Tau accumulation in patients with Alzheimer’s disease tracks closely cognitive decline and plays a role the later stages of progression. This phase 2 study evaluated safety efficacy tilavonemab, an anti-tau monoclonal antibody, early disease. In this 96-week, randomized, double-blind, placebo-controlled (NCT02880956), aged 55–85 years meeting clinical criteria for Clinical Dementia Rating-Global Score 0.5, Mini-Mental State Examination score 22 to 30, Repeatable Battery Assessment...
Abstract Objective To determine if mycophenolate mofetil (MMF) diminishes skin and muscle disease activity in children with juvenile dermatomyositis (DM), thereby permitting a decrease corticosteroid dose. Methods A retrospective data review for 50 DM (mean ± SD age 12.2 5.0 years) who had received MMF 12 months identified the following characteristics: 38 (76%) were girls, 39 (78%) white, 10 (20%) Hispanic, 1 (2%) was African American. The dose frequency, type of infection, white blood cell...
OBJECTIVE To quantify the benefit of unilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on contralateral, ipsilateral, and axial symptoms advanced Parkinson's disease. METHODS Thirty-seven patients received STN DBS were rated Unified Disease Rating Scale (UPDRS) timed tests motor function in "practically defined off" state at baseline 3, 6, 12 months postoperatively. RESULTS UPDRS scores improved significantly relative to preoperative (P < 0.001, 37.1% 1 year). There was...
Asthma is a common complex condition with clear racial and ethnic differences in both prevalence severity. consultation rates, mortality, severe symptoms are greatly increased African descent populations of developed countries. ancestry has been associated asthma, total serum IgE lower pulmonary function African-admixed populations. To replicate previous findings, here we aimed to examine whether was asthma susceptibility Americans. In addition, examined for the first time...
Acute kidney injury is a frequent and serious complication of cardiopulmonary bypass. In current clinical practice, serum creatinine used to detect acute injury. Cystatin C novel biomarker for function that has been shown be superior in predicting adults after The aim this study was determine whether early cystatin levels predict associated with bypass pediatric patients undergoing cardiac surgery if could pediatric-modified RIFLE (Risk, Injury, Failure, Loss, End-stage disease) class renal...
Data from 997 pediatric LT recipients were used to model demographic and medical variables as predictors of lower levels HRQOL. collected through SPLIT FOG project. Patients between 2 18 yr age survived by at least 12 months. Parents children (age ≥ 8 yr) completed PedsQL™ 4.0 Generic Core CF Scales one time point. Demographic obtained SPLIT. HRQOL scores categorized "poor" based on 25% for each measure. Logistic regression models generated. Single-parent households (OR 1.94, CI 1.13-3.33, p...
Japanese encephalitis (JE) is a zoonotic disease caused by the virus (JEV), belonging to Flaviviridae family. Diagnosis of based on clinical signs alone challenging due high proportion subclinical cases. The Plaque Reduction Neutralization Test (PRNT) considered gold standard for detecting JE-specific antibodies because its specificity. However, PRNT complex, time-consuming, and requires live viruses, limiting applicability in routine diagnostics. In this study, we compared sensitivity...
Functional gastrointestinal disorders (FGIDs) are common. Diagnosis is based on the Rome criteria. It has been argued that performing endoscopies could help by providing reassurance and thus improve outcomes. This study was conducted to evaluate impact of obtaining normal in outcome children with FGIDs.Medical records patients diagnosed abdominal pain related-FGIDs were reviewed. To assess child's symptoms at follow-up, parents completed Questionnaire Pediatric Gastrointestinal Symptoms III...
IntroductionHepatitis C virus (HCV) infection is common in patients with end-stage renal disease. We investigated the safety and efficacy of ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r) ± dasabuvir (DSV) ribavirin (RBV) 2 phase 3, open-label, multicenter studies stage 4 or 5 chronic kidney disease (CKD).MethodsRUBY-I, Cohort enrolled treatment-naïve -experienced HCV genotype (GT) 1a 1b infection, without cirrhosis. Patients received 12 weeks (24 for GT1a cirrhosis) OBV/PTV/r + DSV; all...
Abstract Background Electrocardiography remains the best diagnostic tool and therapeutic biomarker for a spectrum of pediatric diseases involving cardiac or autonomic nervous system defects. As genetic links to these disorders are established transgenic mouse models produced in efforts understand treat them, there is surprising lack information on electrocardiograms (ECGs) ECG abnormalities neonate mice. This likely due trauma anaesthesia required many legacy approaches recording mice,...
Increased plasma concentrations of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, decreased arginine bioavailability, and mitochondrial dysfunction have been reported in adult sepsis. We studied whether arginine, carnitine metabolism (a measure dysfunction) are altered pediatric sepsis these clinically useful biomarkers.: Prospective, observational study.Pediatric intensive care unit at an academic medical center.: Ninety patients ≤ 18 yrs old, 30 with severe or...