A5066841660- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Trigeminal Neuralgia and Treatments
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Vestibular and auditory disorders
- Soft tissue tumor case studies
- Advanced Neuroimaging Techniques and Applications
- Surgical Simulation and Training
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Cerebrospinal fluid and hydrocephalus
- Anatomy and Medical Technology
- Digital Imaging in Medicine
University of Alabama at Birmingham
2016-2025
University of Alabama at Birmingham Hospital
2023
University of Washington
2023
Seattle University
2023
Neurological Surgery
2016-2020
Oxford University Press (United Kingdom)
2020
Inova Fairfax Hospital
2018
Nova Medical (United States)
2017
Zero to Three
2016
Hospital for Sick Children
2010
The saccadic system accurately compensates for perturbations of eye position produced by microstimulation the superior colliculus. This requires that information about stimulation-induced change in be provided an extraretinal source—either proprioceptive endings extraocular muscles or a centrally generated corollary discharge. It is shown compensation remains intact after elimination muscle proprioception, demonstrating discharge provides accurate information.
BACKGROUND Pituitary carcinomas are rare adenohypophysial neoplasms, the definition, diagnosis, therapy, and prognosis of which controversial. METHODS were defined as primary neoplasms with documented craniospinal and/or systemic metastases. The authors report a clinicopathologic study 15 examples examined by light microscopy, immunohistochemistry, image analysis. Both proliferative activity p53 tumor suppressor gene expression studied. RESULTS group consisted patients, including 8 males 7...
Abstract Forty-four cases of meningeal hemangiopericytoma that were treated between 1938 and 1987 are reviewed. Fifty-five percent these tumors occurred in men. The average age the patients at diagnosis was 42 years. duration preoperative symptoms 11 months. Symptoms related to tumor location, which similar meningioma. operative mortality 9% overall, has been zero since 1974 (18 patients). time before first recurrence 47 months, with rates 1, 5, 10 years after surgery being 15, 65, 76%,...
Objective A 12‐month double‐blind sham‐surgery–controlled trial assessing adeno‐associated virus type 2 (AAV2)‐neurturin injected into the putamen bilaterally failed to meet its primary endpoint, but showed positive results for endpoint in subgroup of subjects followed 18 months and several secondary endpoints. Analysis postmortem tissue suggested impaired axonal transport neurturin from substantia nigra. In present study, we tested safety efficacy AAV2‐neurturin delivered Methods We...
The World Health Organization (WHO) reclassified atypical meningiomas in 2000, creating a more clear and broadly accepted definition. In this paper, the authors evaluated pathological clinical transition period for according to implementation of new WHO grading system at their institution.A total 471 occurring 440 patients between 1994 2006 were retrospectively reviewed determine changes diagnostic rates, postoperative treatment trends, early outcomes.Between incidence ranged from 0 3/year,...
Volumetric modulated arc therapy (VMAT) has been shown to be feasible for radiosurgical treatment of multiple cranial lesions with a single isocenter.To investigate whether equivalent plan quality and reduced delivery time could achieved in VMAT patients intracranial targets previously treated Gamma Knife (GK) radiosurgery.We identified 28 GK treatments metastases. These were replanned multiarc single-arc, single-isocenter (RapidArc) Eclipse. The prescription all was standardized 18 Gy. Each...
Objective The aim of this study was to investigate the cognitive effects unilateral directional versus ring subthalamic nucleus deep brain stimulation (STN DBS) in patients with advanced Parkinson's disease. Methods We examined 31 participants who underwent STN DBS (left n = 17; right 14) as part an National Institutes Health (NIH)‐sponsored randomized, double‐blind, crossover contrasting stimulation. All received implants hemisphere more severely affected by motor parkinsonism. Measures...
Abstract Neurons that provide sensory and motor innervation of extraocular muscles in the monkey have been identified localized by retrograde transport horseradish peroxidase (HRP). Injections HRP into individual rhesus or pig‐tail monkeys labeled pseudounipolar neurons were within ipsilateral semilunar ganglion. The distribution ganglion was consistent with its somatotopic organization as majority found ophthalmic subdivision. Absence either trigeminal mesencephalic spinal nucleus agreement...
Surgery is a highly technical field that combines continuous decision-making with the coordination of spatiovisual tasks.We designed virtual interactive presence and augmented reality (VIPAR) platform allows remote surgeon to deliver real-time assistance local surgeon, over standard Internet connection.The VIPAR system consisted "local" "remote" station, each situated surgical blue screen, respectively. Each station was equipped digital viewpiece, composed 2 cameras for stereoscopic capture,...
BACKGROUND: Although numerous studies have focused on the efficacy of deep brain stimulation (DBS) for movement disorders, less is known about surgical adverse events, especially over longer time intervals. OBJECTIVE: Here, we analyze events in 510 consecutive cases from a tertiary disorders center at up to 10 years postoperatively. METHODS: We conducted retrospective review craniotomies between January 2003 and March 2013. The were categorized into 2 broad categories—immediate perioperative...
The shortage of surgeons compels the development novel technologies that geographically extend capabilities individual and enhance surgical skills. authors have developed "Virtual Interactive Presence" (VIP), a platform allows remote participants to simultaneously view each other's visual field, creating shared field for real-time telecollaboration.The demonstrate capability VIP facilitate long-distance telecollaboration during cadaveric dissection. Virtual Presence consists local...
The criteria for brain biopsy in patients with acquired immunodeficiency syndrome (AIDS) remain unclear and without universal acceptance. In order to shed more light on this issue, the authors reviewed records of 25 AIDS focal cerebral lesions who consecutively underwent stereotactic between November 1988 October 1990. most frequently occurring diagnoses were lymphoma (36%), progressive multifocal leukoencephalopathy (24%), toxoplasmosis (8%). Patients whose central nervous system disease...
OBJECTIVE To quantify the benefit of unilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on contralateral, ipsilateral, and axial symptoms advanced Parkinson's disease. METHODS Thirty-seven patients received STN DBS were rated Unified Disease Rating Scale (UPDRS) timed tests motor function in "practically defined off" state at baseline 3, 6, 12 months postoperatively. RESULTS UPDRS scores improved significantly relative to preoperative (P < 0.001, 37.1% 1 year). There was...
Melanoma is the primary malignancy that most likely to metastasize brain. Because such an event carries almost uniformly poor prognosis, current study reviewed outcomes and identified associated prognostic indicators for 51 consecutive patients receiving gamma knife (GK) radiosurgery in initial treatment of 188 intracranial melanoma metastases.Data were collected retrospectively from a single-center GK database patient medical records radiographs.At presentation, 71% had multiple metastases,...
Multiple studies have shown bilateral improvement in motor symptoms Parkinson disease (PD) following unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) and internal segment globus pallidus, yet mechanism(s) underlying this phenomenon are poorly understood. We hypothesized that STN neuronal activity is altered by contralateral DBS. This hypothesis was tested intraoperatively humans with advanced PD using microelectrode recordings during demonstrate alterations discharge...