A5049564203- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Electrochemical Analysis and Applications
- Olfactory and Sensory Function Studies
- Sleep and related disorders
- Ginkgo biloba and Cashew Applications
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Circadian rhythm and melatonin
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Autism Spectrum Disorder Research
- Medical Imaging Techniques and Applications
University of Genoa
2020-2025
Ospedale Policlinico San Martino
2020-2025
Zero to Three
2022
Istituto delle Scienze Neurologiche di Bologna
2021
Ente Ospedaliero Ospedali Galliera
2020
Abstract The neurodegenerative synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive subclinical motor non-motor manifestations. Among these, idiopathic REM sleep behaviour disorder is powerful early predictor eventual phenoconversion, therefore represents critical opportunity to intervene neuroprotective therapy. To inform the design randomized trials, it essential study natural progression...
Abstract INTRODUCTION Isolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) is a powerful early predictor of dementia with Lewy bodies (DLB) and Parkinson's disease (PD). This provides an opportunity to directly observe the evolution prodromal DLB identify which cognitive variables are strongest predictors evolving dementia. METHODS IRBD participants ( n = 754) from 10 centers International RBD Study Group underwent annual neuropsychological assessment. Competing risk...
Objective To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) predict the development Parkinson disease (PD) dementia Lewy bodies (DLB). Method s In this multicenter study International RBD group, 173 (mean age 70.5 ± 6.3 years, 70.5% males) polysomnography‐confirmed who eventually phenoconverted overt alpha‐synucleinopathy (RBD due synucleinopathy) were enrolled, underwent baseline...
Abstract Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. Recent literature has proposed two subgroups PD. The “body-first subtype” associated with prodrome isolated REM-sleep Behavior Disorder (iRBD) and relatively symmetric brain degeneration. “brain-first suggested to have more asymmetric degeneration prodromal stage without RBD. This study aims investigate difference symmetry pattern presumed body brain-first PD subtypes. We...
Abstract Study Objectives Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA). Associations baseline resting-state electroencephalography (EEG) phenoconversion have been reported. In this study, we aimed develop machine learning models predict time subtype using EEG features in...
Background:Seizures are common in patients with dementia but precise epidemiologic data of epilepsy neurodegenerative is lacking. Objective:The first aim the study was to investigate prevalence and clinical characteristics a large cohort neurodegenerat ive dementias. Subsequently, we explored clinical, neuropsychological, quantitative electroencephalogram (qEEG) Alzheimer's disease (AD) (AD-EPI) as compared AD without (AD-CTR). Methods:We retrospectively evaluated consecutive diagnosis...
Background: Circadian and sleep disturbances are associated with increased risk of mild cognitive impairment (MCI) Alzheimer’s disease (AD). Wearable activity trackers could provide a new approach in diagnosis prevention. Objective: To evaluate circadian rhythm parameters, through wearable trackers, MCI AD patients as compared to controls, focusing on sex dissimilarities. Methods: Based minute level data from consumer devices, we analyzed actigraphic parameters by applying an electromedical...
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson's Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain. We investigated the capability of baseline brain [
<title>Abstract</title> Purpose: Center-specific effects in PET brain scans arise due to differences technical and procedural aspects. This restricts the merging of data between centers introduces source-specific bias. Methods: We demonstrate use recently proposed machine learning method Iterated Relevance Matrix Analysis (IRMA) for harmonization center-specific <sup>18</sup>F-Fluorodeoxyglucose (<sup>18</sup>F-FDG) scans. The center difference is learned by applying IRMA on PCA-based...
Nigrostriatal dopaminergic degeneration in alpha-synucleinopathies is indirectly reflected by low dopamine transporter (DaT) uptake through [123I]FP-CIT-SPECT. Bulk magnetic susceptibility ( $$\chi$$ ) the substantia nigra, from MRI-based quantitative mapping (QSM), a potential biomarker of nigrostriatal degeneration, however, QSM cannot disentangle paramagnetic (e.g. iron) and diamagnetic myelin) sources. Using source-separation technique DECOMPOSE, component (PCS) (DCS) were studied...
Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder, with considerable variability of age-at-onset. We explored clinical and metabolic differences between early- late-onset behavioural FTD (bvFTD), assuming that they might represent different disease phenotypes. retrospectively studied consecutive patients diagnosed prodromal or overt bvFTD [18F]FDG PET scan, neuropsychological assessment (NPS), Neuropsychiatric Inventory (NPI) available at baseline. Patients were...
Dementia with Lewy Bodies (DLB) is a heterogeneous disease characterized by four core clinical features, namely visual hallucinations, REM sleep behaviour disorder (RBD), cognitive fluctuations and parkinsonism. In this paper, we perform for the first time comprehensive study on relationship between all these features functional connectivity derived from high-density electroencephalographic data. To quantify connectivity, used two different metrics, each one averaged individual theta alpha...
ABSTRACT Background People with idiopathic/isolated REM sleep behavior disorder (iRBD) are highly heterogeneous, showing mild motor, cognitive, and dysautonomia symptoms. The aim of this study is to unveil the clinical heterogeneity iRBD a specific reference overlapping features prodromal Parkinson's disease (pPD) dementia Lewy bodies (pDLB) labels. Methods polysomnography‐confirmed diagnosis were enrolled followed over time. At baseline, pPD pDLB criteria assessed. Results Among 285 people...
Abstract Isolated REM sleep behavior (iRBD) is a male predominant parasomnia characterized by abnormal dream-enacting movements in sleep. It the prodromal manifestation most strongly associated with development of synucleinopathies, such as Parkinson’s disease or dementia Lewy bodies. While individuals iRBD exhibit significant cortical atrophy shaped distinct gene expression, sex-specific differences structural brain changes remain unknown. In this study, we investigate effect sex on and...
Synucleinopathies include a spectrum of disorders varying in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD), Parkinson's disease (PD), dementia with Lewy bodies (DLB). Distinct brain atrophy patterns may already be seen iRBD; however, how begins progresses remains unclear. A multicentric cohort 1276 participants (451 polysomnography-confirmed iRBD, 142 PD probable RBD, 87 DLB, 596 controls) underwent T1-weighted MRI longitudinal clinical assessments....
Theory of mind (ToM, the ability to attribute mental states others) deficit is a frequent finding in neurodegenerative conditions, mediated by diffuse brain network confirmed 18F-FDG-PET and MR imaging, involving frontal, temporal parietal areas. However, role hubs spokes regions ToM performance, their respective damage, still unclear. To study this mechanism, we combined testing with imaging 25 subjects mild cognitive impairment due Alzheimer’s disease (MCI−AD), 24 behavioral variant...
Idiopathic/isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is considered the prodromal stage of alpha-synucleinopathies. Thus, iRBD patients are ideal target for disease-modifying therapy. The risk FActoRs PREdictive phenoconversion in Italian STudy (FARPRESTO) an ongoing database aimed at identifying factors phenoconversion, and eventually to ease clinical trial enrollment well-characterized subjects.Polysomnography-confirmed were retrospectively prospectively enrolled....
Many physiological processes in the human body follow a 24-h circadian rhythm controlled by clock system. Light, sensed retina, is predominant "zeitgeber" able to synchronize rhythms light-dark cycles. Circadian dysfunction and sleep disorders have been associated with aging neurodegenerative diseases including mild cognitive impairment (MCI) Alzheimer's disease (AD). In present study, we aimed at investigating genetic variability of genes AD patients compared healthy controls from Italy. We...
Abstract Background A brain glucose metabolism pattern related to phenoconversion in patients with idiopathic/isolated REM sleep behaviour disorder (iRBDconvRP) was recently identified. However, the validation of iRBDconvRP an external, independent group iRBD is needed verify reproducibility such pattern, so increase its importance clinical and research settings. The aim this work validate patients. Methods Forty (70 ± 5.59 years, 19 females) underwent [ 18 F]FDG-PET Seoul National...