A5006298497- Chemokine receptors and signaling
- Hematopoietic Stem Cell Transplantation
- Migraine and Headache Studies
- Ophthalmology and Eye Disorders
- SARS-CoV-2 and COVID-19 Research
- Alzheimer's disease research and treatments
- Histone Deacetylase Inhibitors Research
- Peripheral Neuropathies and Disorders
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Immune Response and Inflammation
- Trigeminal Neuralgia and Treatments
- Chemotherapy-induced organ toxicity mitigation
- TGF-β signaling in diseases
- Plant-based Medicinal Research
- Cancer Treatment and Pharmacology
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Cancer-related cognitive impairment studies
- Bone Metabolism and Diseases
- Cancer, Stress, Anesthesia, and Immune Response
Eulji University
2024-2025
Kyungpook National University
2014-2017
Matrix Research (United States)
2017
Abstract Hematopoietic stem/progenitor cell (HSPC) mobilization is an essential homeostatic process regulated by the interaction of cellular and molecular components in bone marrow niches. It has been shown others that neurotransmitters released from sympathetic nervous system regulate HSPC egress to peripheral blood. In this study, we investigate functional role neuropeptide Y (NPY) on process. NPY deficient mice had significantly impaired due increased expression maintenance factors...
Tuberculous meningitis (TBM) is fatal unless treated promptly. Nonconvulsive status epilepticus (NCSE) may cause altered consciousness in patients with TBM. A 25-year-old female presented to the emergency department a headache and fever along multiple associated symptoms that had developed 2 days prior. Based on clinical findings, brain imaging, cerebrospinal fluid (CSF) examination, she was tentatively diagnosed viral meningitis. Later, focal seizures, follow-up CSF examination findings...
Objectives: Narcolepsy significantly affects the daily life of individuals due to excessive daytime sleepiness and cataplexy, reducing quality increasing risk accidents social difficulties. Despite its profound impact on life, only a few studies have investigated specific difficulties awareness patients with narcolepsy. Therefore, in this study, we aimed assess challenges disease Methods: We conducted an online survey 299 The included questions patient demographics, clinical characteristics,...
Monoclonal antibodies (mAbs) targeting calcitonin-gene-related peptide (CGRP) or its receptor (anti-CGRP-R) have been widely administered to patients with migraine who show inadequate responses preventive medications. Among in whom a particular anti-CGRP-R mAb is ineffective, switching between different mAbs can be the next option. Few studies investigated treatment outcomes for antibody switching, especially same target of CGRP ligand. We aimed determine outcome after two anti-CGRP...
Inhibition of an increase osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays role in mobilization osteoclast precursors within bone marrow (BM). However, actual therapeutic impact AMD3100 osteoporosis not yet been ascertained. Here we demonstrate effect ovariectomy-induced mice. We found that with resulted direct induction release SDF-1 from BM to blood and hematopoietic stem/progenitor cells (HSPCs) model. prevented density loss after...
Cisplatin is a platinum-based chemotherapeutic drug for treating various types of cancers. However, the use cisplatin limited by its negative effect on normal tissues, particularly nephrotoxicity. Various mechanisms such as DNA adduct formation, mitochondrial dysfunction, oxidative stress, and apoptosis are involved in adverse induced treatment. Several studies have suggested that neuropeptide Y (NPY) neuroprotection well restoration bone marrow dysfunction from chemotherapy nerve injury....
Ovariectomy-induced bone loss is related to an increased deposition of osteoclasts on surfaces. We reported that the 36-amino-acid-long neuropeptide Y (NPY) could mobilize hematopoietic stem/progenitor cells (HSPCs) from marrow peripheral blood by regulating HSPC maintenance factors and mobilization HSPCs ameliorated low density in ovariectomy-induced osteoporosis mouse model reducing number osteoclasts. Here, we demonstrated new NPY peptides, recombined cleavage full-length NPY, showed...
Restless legs syndrome (RLS) is a chronic sensory-motor neuron disorder characterized by an urge to move the legs, accompanied abnormal sensations and pain that occur during sitting resting periods but are relieved movement. Although RLS typically affects lower limbs, cases of localized sensation in chest, back, abdomen, arm, perineum have also been reported. To date, only one documented case upper back has In this report, we present rare variant manifests as symptoms back.
<h3>Objective:</h3> To report the crude incidence rate of GBS following SARS-CoV-2 vaccination; evaluate how vaccine dose, mechanism, age, and sex may affect risk clinically compare head-to-head cases two major mechanisms vaccines. <h3>Background:</h3> Increasing evidence suggests an association between vaccines Guillain-Barré syndrome (GBS). Nevertheless, little is understood about contributing factors clinical characteristics post vaccination. <h3>Design/Methods:</h3> In this prospective...