A5100416698- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Neurological and metabolic disorders
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Ginkgo biloba and Cashew Applications
- Neuroscience and Neuropharmacology Research
- Cerebrospinal fluid and hydrocephalus
- Obsessive-Compulsive Spectrum Disorders
- Advanced Neuroimaging Techniques and Applications
- Dysphagia Assessment and Management
- Nuclear Receptors and Signaling
- Ophthalmology and Eye Disorders
- Autism Spectrum Disorder Research
- Spinal Dysraphism and Malformations
- Trigeminal Neuralgia and Treatments
- Trace Elements in Health
- Parkinson's Disease and Spinal Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Facial Nerve Paralysis Treatment and Research
- Neurofibromatosis and Schwannoma Cases
- Sleep and Wakefulness Research
Daegu Fatima Hospital
2016-2025
National University College
2016-2024
Seoul National University Bundang Hospital
2015-2024
New Generation University College
2007-2024
Seoul National University
2001-2022
Seoul National University Hospital
2009-2022
Neurology, Inc
2001-2021
Seoul Metropolitan Government
2018
Boramae Medical Center
2018
Myongji Hospital
2017
Background Brain glymphatic dysfunction may contribute to the development of α-synucleinopathies. Yet, noninvasive imaging and quantification remain lacking. Purpose To examine function brain in isolated rapid eye movement sleep behavior disorder (RBD) its relevance phenoconversion with use diffusion-tensor (DTI) analysis along perivascular space (ALPS). Materials Methods This prospective study included consecutive participants diagnosed RBD, age- sex-matched control participants, Parkinson...
<h3>Objective</h3> To analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD). <h3>Methods</h3> Forty-nine patients with PD 54 age-matched controls were analyzed. Ophthalmologic examination macula optical coherence tomography scans performed additional microperimetry, <i>N</i>-(3-[<sup>18</sup>F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane PET, 3T MRI done only. Retinal layer thickness volume measured subfields of 1-,...
While many infectious disorders are unknown to most neurologists, COVID-19 is very different. It has impacted neurologists and other health care workers, not only in our professional lives but also through the fear panic within own families, colleagues, patients their even wider public. affects all sorts of individuals, elderly with underlying chronic conditions particularly at risk severe disease, or death. Parkinson's disease (PD) shares a common profile as an age-dependent degenerative...
IntroductionGlymphatic dysfunction can contribute to α-synucleinopathies. We examined glymphatic function in idiopathic Parkinson's disease (PD) utilizing Diffusion Tensor Image Analysis aLong the Perivascular Space (DTI-ALPS).MethodsThis study enrolled consecutive patients diagnosed with de novo PD between June 2017 and March 2019 who underwent brain DTI concurrent 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) SPECT, age- sex-matched controls. From...
<h3>Objectives</h3> To examine the presence of an<i>ATXN2</i>mutation in patients with parkinsonism Korean population and to find difference the<i>ATXN2</i>mutation between ataxic parkinsonian phenotypes. <h3>Design</h3> Survey. <h3>Setting</h3> Seoul National University Hospital (a referral center). <h3>Patients</h3> Patients Parkinson disease (PD) (n = 468) variant multiple system atrophy (MSA-P) 135) who were seen at our Department Neurology during past 3 years. <h3>Main Outcome...
Abstract Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging SN has been regarded to hold greatest potential for use diagnosis PD. At 7.0T magnetic resonance (MRI), it now possible delineate clearly shapes and boundaries SN. We scanned eight early two advanced PD patients, along with nine age‐matched control subjects, using MRI an attempt directly visualize quantify...
<h3>Background</h3> Idiopathic REM (rapid eye movement) sleep behaviour disorder (iRBD) has been implicated in cognitive impairments, but there is little evidence about progression of dysfunction iRBD. <h3>Methods</h3> A retrospective follow-up study with patients iRBD was performed. Conversion to neurodegenerative disorders analysed by Kaplan-Meier survival analysis. Neuropsychological test results at baseline were compared between and healthy controls. 57 successfully followed up for...
Abstract The clinical distinction between dopa‐responsive dystonia (DRD) and juvenile Parkinson's disease (JPD) can pose a diagnostic challenge. Both conditions are dopa responsive. However, long‐term L‐dopa benefit is very different the two. difference in prognosis due to presence or absence of nigral cell loss. In JPD, there degenerative loss, wherease enzymatic defects dopamine synthesis without loss DRD. Mutations have been found GTP cyclohydrolase I (GCH‐I) tyrosine hydroxylase genes As...
Abstract The etiologies and prevalence of sporadic, postlingual-onset, progressive auditory neuropathy spectrum disorder (ANSD) have rarely been documented. Thus, we aimed to evaluate the molecular these cases. Three out 106 sporadic hearing losses turned manifest ANSD. Through whole exome sequencing subsequent bioinformatics analysis, two three were found share a de novo variant, p.E818K ATP1A3 , which had reported cause exclusively CAPOS (cerebellar ataxia, areflexia, pes cavus, optic...
Purpose To examine whether the loss of nigral hyperintensity (NH) on 3.0-T susceptibility-weighted (SW) magnetic resonance (MR) images can help identify high synucleinopathy risk in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Materials and Methods Between March 2014 April 2015, 18 consecutively recruited iRBD were evaluated SW imaging iodine 123–2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) single photon emission computed...
We analyzed the publication and submission statuses of Korean medical journals from 2010 to 2024, amidst challenges impacting researchers. Data 58 domestic identified through 2023 JCR database were used assess status, while data
Background Diagnosis and treatment of flatfoot are often overlooked. Current diagnostic methods, such as lateral foot radiography physical examination, primarily assess simple static conditions. The Footscan test can be employed to evaluate the dynamic balance patients with flatfoot; however, precise reference value for various results remains undetermined. Objective This study aimed contribute body knowledge regarding diagnosis by identifying objective differences between without flatfoot....
Although human amniotic mesenchymal stem cells (AMMs) have been recognised as a promising cell resource, their therapeutic potential for wound healing has not widely investigated.In this study, we evaluated the of AMMs using diabetic mouse model.Quantitative real-time PCR and ELISA results revealed that angiogenic factors, IGF-1, EGF IL-8 were markedly upregulated in when compared with adipose-derived (ADMs) dermal fibroblasts.In vitro scratch assays also showed AMM-derived conditioned media...
Abstract We aimed to compare Dysport (abobotulinumtoxinA, Ipsen Biopharm, Slough, UK) and Botox (onabotulinumtoxinA, Allergan, Irvine, CA, USA) at a 2.5:1 ratio in the treatment of cervical dystonia (CD). A Dysport/Botox lower than 3:1 was suggested as more appropriate conversion ratio, considering its higher efficacy frequent incidence adverse effects not only CD but also other focal movement disorders. randomized, double‐blind, multicenter, non‐inferiority, two‐period crossover study done...