A5100455088- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Parkinson's Disease and Spinal Disorders
- Transcranial Magnetic Stimulation Studies
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Neonatal and fetal brain pathology
- Neurological diseases and metabolism
- Genetics and Neurodevelopmental Disorders
- Cerebrovascular and Carotid Artery Diseases
- Pain Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Biochemical Analysis and Sensing Techniques
- Bacterial Infections and Vaccines
- Genomics and Rare Diseases
- Glaucoma and retinal disorders
- biodegradable polymer synthesis and properties
- Ophthalmology and Eye Disorders
- Anesthesia and Sedative Agents
Hallym University Sacred Heart Hospital
2015-2024
Hallym University
2014-2024
Korea Research Institute of Standards and Science
2021-2024
Gwangju Institute of Science and Technology
2023-2024
Seoul National University Hospital
2011-2023
Seoul Metropolitan Government
2023
Seoul National University
2008-2023
Boramae Medical Center
2023
Hallym University Dongtan Sacred Heart Hospital
2023
Korea Electronics Technology Institute
2023
Abstract The accumulation of alpha-synuclein (αSyn) is widely recognized as the main pathological process in Parkinson’s disease (PD). Additionally, neuroinflammation considered to be one contributing mechanisms development PD. In light this, it hypothesized that reactive microglia exacerbate propagation αSyn and neurodegeneration, while inhibition microglial activity may mitigate these effects. To test this hypothesis, preformed fibrils (PFF)-injected PD mouse model was employed....
Owing to the rise in global population and living standards, waste treatment has inevitably become a critical issue for sustainable environment. In particular, an effective recycling process, it is vital disassemble different types of materials by removing adhesives used packaging. However, this removal process requires harsh solvents (acidic organic) that are unfriendly nature may cause additional pollution. To address issue, functional adhesive can be removed without use have drawn...
Abstract Akkermansia muciniphila has received great attention because of its beneficial roles in gut health by regulating immunity, promoting intestinal epithelial development, and improving barrier integrity. However, A. -derived functional molecules are not well understood. Microbiome-secreted proteins act as key arbitrators host-microbiome crosstalk through interactions with host cells the important for understanding relationships. Herein, we report biological function Amuc_1409, a...
Abstract We aimed to compare Dysport (abobotulinumtoxinA, Ipsen Biopharm, Slough, UK) and Botox (onabotulinumtoxinA, Allergan, Irvine, CA, USA) at a 2.5:1 ratio in the treatment of cervical dystonia (CD). A Dysport/Botox lower than 3:1 was suggested as more appropriate conversion ratio, considering its higher efficacy frequent incidence adverse effects not only CD but also other focal movement disorders. randomized, double‐blind, multicenter, non‐inferiority, two‐period crossover study done...
Abstract Severe intraventricular hemorrhage (IVH) in premature infants triggers reactive gliosis, causing acute neuronal death and glial scar formation. Transplantation of mesenchymal stem cells (MSCs) has often showed improved CNS recovery an IVH model, but whether this response is related to still unclear. Herein, we suggest that MSCs impede the microglia rather than astrocytes, thereby blocking damage. Astrocytes alone mild reactiveness under hemorrhagic conditions mimicked by thrombin...
Meningitis by Toxocara canis after Ingestion of Raw Ostrich LiverRecently reports on toxocariasis are increasing serodiagnosis in Korea.A previously healthy 17-yr-old boy complained headache, fever, dyspnea, and anorexia.He showed symptoms signs eosinophilic meningitis with involvement the lungs liver.Specific IgG antibody to larval antigen was positive serum cerebrospinal fluid ELISA.He took raw ostrich liver his parents 4 weeks before symptom onset.His were seropositive for T. but had no...
According to a few studies, α-synuclein (αSyn) propagation has been suggested play key role in the pathomechanism of Parkinson's disease (PD), but neurodegeneration and involvement inflammation its pathologic progression are not well understood with regard temporal relationship. In this study, help PD mouse model injected intrastriatal αSyn preformed fibril (PFF), evolution propagation, inflammation, was explored perspective striatum whole brain. PFF-injected striatum, inflammatory response...
REM sleep behavior disorder (RBD) in Parkinson's disease (PD) is associated with characteristic clinical subtypes and prognosis. In addition, nigrostriatal pathway, the most vulnerable anatomical area PD, formed neuronal network interplaying cortical subcortical structures, which may cause PD phenotype. We evaluated regional selectivity of presynaptic striatal dopaminergic denervation RBD PD.We compared two groups (n = 16) patients without terms specific binding ratios (SBR) subregions...
We investigated the effect of propofol and fentanyl on microelectrode recording (MER) its clinical applicability during subthalamic nucleus (STN) deep brain stimulation (DBS) surgery. analyzed 8 patients with Parkinson's disease, underwent bilateral STN DBS MER. Their left sides were done under awake then their right a continuous infusion local anesthesia. The electrode position was evaluated by preoperative MRI postoperative CT. outcomes assessed at six months after isolated single unit...
ObjectiveaaNeurodegeneration with brain iron accumulation (NBIA) represents a group of inherited movement disorders characterized by in the basal ganglia.Recent advances have included identification new causative genes and highlighted wide phenotypic variation between within specific NBIA subtypes.This study aimed to investigate current status Korea.MethodsaaWe collected genetically confirmed patients from twelve nationwide referral hospitals review literature.We conducted describe genotypic...
Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark Parkinson's disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved the pathogenesis PD. Thus, achieving better understanding interaction between inflammation and synucleinopathy relation to PD process will facilitate development promising disease-modifying therapies. this review, discussed, human, animal, laboratory studies relevant relationship...