A5074102803- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Sleep and Wakefulness Research
- Neurological and metabolic disorders
- Genetic Associations and Epidemiology
- Sleep and related disorders
- Genomics and Rare Diseases
- EEG and Brain-Computer Interfaces
- Nuclear Receptors and Signaling
- Cerebrospinal fluid and hydrocephalus
- Balance, Gait, and Falls Prevention
- Moyamoya disease diagnosis and treatment
- Bioinformatics and Genomic Networks
- Amyotrophic Lateral Sclerosis Research
- Intracranial Aneurysms: Treatment and Complications
- Autoimmune Neurological Disorders and Treatments
- Cancer Research and Treatment
- Heat shock proteins research
- Advanced MRI Techniques and Applications
- Ophthalmology and Eye Disorders
- Lysosomal Storage Disorders Research
- Epilepsy research and treatment
Keimyung University
2015-2024
Keimyung University Dongsan Medical Center
2014-2023
Yonsei University
2021
Goethe University Frankfurt
2018-2019
University Hospital Frankfurt
2018-2019
Ewha Womans University
2019
Soochow University
2017
Second Affiliated Hospital of Soochow University
2017
Korea Brain Research Institute
2016
University of Ulsan
2011-2015
Recent genome-wide association studies (GWAS) have discovered several Alzheimer disease (AD) susceptibility loci. However, the identified loci are substantially inconsistent across GWAS. We aimed to investigate of top associated variants in GWAS with AD Korean population. selected 86 single-nucleotide polymorphisms (SNPs) from 12 genes (ABCA7, APOE, BIN1, CD2AP, CD33, CLU, CR1, EPHA1, LRAT, MS4A6A, PCDH11X, and PICALM) genotyped 290 cases 554 unrelated controls same region. Three SNPs...
Abstract We aimed to compare Dysport (abobotulinumtoxinA, Ipsen Biopharm, Slough, UK) and Botox (onabotulinumtoxinA, Allergan, Irvine, CA, USA) at a 2.5:1 ratio in the treatment of cervical dystonia (CD). A Dysport/Botox lower than 3:1 was suggested as more appropriate conversion ratio, considering its higher efficacy frequent incidence adverse effects not only CD but also other focal movement disorders. randomized, double‐blind, multicenter, non‐inferiority, two‐period crossover study done...
Autonomic symptoms are commonly observed in patients with Parkinson's disease (PD) and often limit the activities of daily living. The Scale for Outcomes disease-Autonomic (SCOPA-AUT) was developed to evaluate quantify autonomic PD. goal this study translate original SCOPA-AUT, which written English, into Korean its reliability validity PD patients.For translation, following processes were performed: forward backward expert review, pretest pre-final version development final SCOPA-AUT...
Study Objectives: REM sleep behavior disorder (RBD) is a parasomnia that commonly associated with neurodegenerative disorders.We aimed to validate the Hong Kong version of self-reported RBD questionnaire (RBDQ-HK) Korean (RBDQ-KR) and investigate its clinical usefulness.Methods: One-hundred five patients 105 age-and sex-matched controls were enrolled.Thirty randomly selected for retest after 2 4 weeks without any treatment.Receiver operating characteristic curve exploratory factor analysis...
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by interruption or trauma due to abnormal behaviors that occur during REM sleep. The pathophysiology of RBD known be dysfunction brainstem circuit causes the loss skeletal muscle atonia diagnosis needed confirm without in polysomnography. management includes not only drug treatment, but also prevent injury from and follow-up on neurodegenerative diseases may later. thought prodromal stage disease associated...
Background Recently, non-motor symptoms of Parkinson's disease (PD) have been considered crucial factors in determining a patient's quality life and proposed as the predominant features premotor phase. Researchers investigated relationship between motor laterality; however, this remains disputed. This study neural connectivity correlates PD with respect to laterality. Methods Eight-seven patients were recruited classified into left-more-affected (n = 44) right-more affected 37) based on...
Background and PurposeWe investigated the frequency clinical features of restless legs syndrome (RLS) in patients with Parkinson's disease (PD).Methods This study included 74 PD patients.RLS was diagnosed face-to-face assessments all subjects based on diagnostic criteria International Restless Legs Syndrome Study Group revised 2003.We analyzed without RLS compared data to idiopathic RLS. ResultsThe cohort 21.6% (n=16).Two (12.5%) were not treated dopaminergic drugs, while 14 (24.1%) 58...
We performed pupillometer testing on 132 patients with Parkinson's disease, stratified into two groups according to the disease stage. Neurological examinations and pupillometry were in ON state. Patients Hoehn Yahr stages 1 2 comprised early group, 3-5 formed late group. age- sex-matched (2:1) propensity score matching compensate for effect of age pupil light reflex. Eight parameters measured compared between groups. After matching, group had 64 32 patients. The a longer duration took...
This study aimed to determine the clinimetric properties of Korean version Parkinson's Disease Sleep Scale-2 (K-PDSS-2) and whether distinct subtypes sleep disturbance can be empirically identified in patients with disease (PD) using cross-culturally validated K-PDSS-2.The internal consistency, test-retest reliability, scale precision, convergent validity K-PDSS-2 were assessed a nationwide, multicenter 122 PD. Latent class analysis (LCA) was used derive subgroups who experienced similar...
Objective The Scales for Outcomes in Parkinson’s Disease–Cognition (SCOPA-Cog) was developed to assess cognition patients with disease (PD). In this study, we aimed evaluate the validity and reliability of Korean version SCOPACog (K-SCOPA-Cog).Methods We enrolled 129 PD movement disorders from 31 clinics South Korea. original SCOPA-Cog translated into using translation-retranslation method. test–retest method an intraclass correlation coefficient (ICC) Cronbach’s alpha were used reliability....
ObjectiveaaTo compare the therapeutic and adverse effects of globus pallidus interna (GPi) subthalamic nucleus (STN) deep brain stimulation (DBS) for treatment advanced Parkinson's disease (PD).MethodsaaWe retrospectively analyzed clinical data patients with PD who underwent GPi (n = 14) or STN 28) DBS surgery between April 2002 May 2014.The subjects were matched age at duration.The Unified Disease Rating Scale (UPDRS) scores levodopa equivalent dose (LED) baseline 12 months after used to...
There have been several pathologic data that support an association between postural instability (PI) and autonomic dysfunction in Parkinson's disease (PD). The purpose of this study was to investigate the correlation PI deficits early PD.We collected 17 patients with a diagnosis PD. assessed by computerized dynamic posturography (CDP). Standardized function test (AFT) time frequency domain spectral analysis heart rate variability (HRV) were performed. CDP obtained from 21 compared age-...
Background: Sleep problems commonly occur in patients with Parkinson's disease (PD), and are associated a lower quality of life.The aim the current study was to translate English version Scales for Outcomes Disease-Sleep (SCOPA-S) into Korean SCOPA-S (K-SCOPA-S), evaluate its reliability validity use by Korean-speaking PD.Methods: In total, 136 PD from 27 movement disorder centres university-affiliated hospitals Korea were enrolled this study.They assessed using SCOPA, Hoehn Yahr Scale...
Impulse-control disorder is an important nonmotor symptom of Parkinson's disease (PD) that can lead to financial and social problems, be related a poor quality life. A nationwide multicenter prospective study was performed with the aim validating Korean Version Questionnaire for Impulsive-Compulsive Disorders in Disease Rating Scale (K-QUIP-RS).The K-QUIP-RS constructed using forward backward translation, pretesting prefinal version. PD patients on stable medical condition were recruited...
Hand tremor is one of the most frequent symptoms in movement disorders, and differential diagnoses for hand include Parkinson's disease (PD) essential (ET). However, accurately differentiating between PD ET clinical practice remains challenging patients presenting with tremor. We investigated whether a questionnaire-based survey could be useful as screening tool A questionnaire related to consisting 12 items was prospectively applied or three movement-disorder clinics. Each question...