A5017920022- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Balance, Gait, and Falls Prevention
- Neurological and metabolic disorders
- Cerebrospinal fluid and hydrocephalus
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Cerebral Palsy and Movement Disorders
- Acute Ischemic Stroke Management
- Vestibular and auditory disorders
- Neurological diseases and metabolism
- Autoimmune Neurological Disorders and Treatments
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Glycogen Storage Diseases and Myoclonus
- Hearing, Cochlea, Tinnitus, Genetics
- Olfactory and Sensory Function Studies
- Multiple Sclerosis Research Studies
- EEG and Brain-Computer Interfaces
- Parkinson's Disease and Spinal Disorders
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
Soonchunhyang University Hospital
2016-2025
Soonchunhyang University
2018-2024
Jeonbuk National University
2024
Korea University Medical Center
2014-2023
Korea University
2014-2019
Seoul National University
2013
Korea Advanced Institute of Science and Technology
2011
University of Ulsan
2007-2009
Asan Medical Center
2007-2009
Ulsan College
2007-2009
Aim Patients with Parkinson's disease (PD) present both motor and non‐motor symptoms, understanding the interplay between these symptoms is crucial for individualized patient care. This study aims to investigate relationship features in patients de novo PD. Methods A total of 105 were analyzed, focusing on subtypes or subscores their impact cognition, depression, anxiety, fatigue, dysautonomia. We utilized Unified Disease Rating Scale–part III (UPDRS‐III) assessment, various validated scales...
Mutations in PINK1 (PTEN-induced putative kinase 1) are tightly linked to autosomal recessive Parkinson disease (PD). Although more than 50 mutations have been discovered, the role of these PD pathogenesis remains poorly understood. Here, we characterized 17 representative pathogenic both mammalian cells and Drosophila. These did not affect typical cleavage patterns subcellular localization under normal damaged mitochondria conditions cells. However, domain failed translocate Parkin induce...
Falls are not uncommon even in patients with early stages of Parkinson's disease (PD). The aims this study were to determine the relationships between gait parameters and falls identify crucial for predicting future de novo PD.
Background and Purpose— Early recurrent ischemic lesions (ERILs) on diffusion-weighted imaging after acute stroke have been suggested as a potential marker of early stroke. We hypothesized that biomarkers inflammation or coagulation may be associated with the pathogenesis ERILs sought to investigate whether these provide prognostic information risk development independently clinical variables. Methods— This prospective study enrolled 153 consecutive patients who underwent within 24 hours...
Autonomic symptoms are commonly observed in patients with Parkinson's disease (PD) and often limit the activities of daily living. The Scale for Outcomes disease-Autonomic (SCOPA-AUT) was developed to evaluate quantify autonomic PD. goal this study translate original SCOPA-AUT, which written English, into Korean its reliability validity PD patients.For translation, following processes were performed: forward backward expert review, pretest pre-final version development final SCOPA-AUT...
Abstract The risk factors of mild cognitive impairment (MCI) in patients with de novo Parkinson’s disease (PD) remain unclear. Therefore, the objective this study was to compare motor and non-motor symptoms between PD without MCI. Moreover, detailed relationships each deficit other clinical characteristics were investigated. Consecutive retrospectively enrolled study. Motor assessed using Unified Disease Rating Scale (UPDRS) part-III Hoehn Yahr (HY) stage. Non-motor including depression,...
Abstract To investigate the diagnostic value of brain magnetic resonance image (MRI) and 18 F‐fluorodeoxyglucose positron emission tomography ( F‐FDG PET) in differentiation multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty‐five patients with MSA (23 MSA‐P 12 MSA‐C) 17 PD were included this study. Overall correct diagnosis rates between clinical imaging among MSA‐P, MSA‐C, 80% for visual MRI analysis, 88.5% PET 84.3% SPM‐supported analysis PET. The sensitivity MRI, SPM...
<h3>Background</h3> Prior observations have shown that early recurrent ischemic lesions (ERILs) on diffusion-weighted imaging occur frequently within the first week after an index stroke. <h3>Objective</h3> To investigate differential patterns of ERILs among stroke subtypes, particularly intracranial large-artery atherosclerosis (IC-LAA). <h3>Design</h3> Retrospective study. <h3>Setting</h3> Tertiary university hospital. <h3>Patients</h3> We included 133 patients who experienced acute and...
Abstract Background Cognitive impairments are common in Parkinson’s disease (PD). Despite its clinical importance, the development of dementia is still difficult to predict. In this study, we investigated possible associations between non-motor symptoms and risk developing within a 2-year observation period PD. Methods A total 80 patients with PD participated study. Nonmotor (the Symptoms Questionnaire), status (Unified Disease Rating Scale), depression (Geriatric d Depression Scale or...
Abstract The association of non-motor symptoms (NMSs) with fall-related factors in patients Parkinson’s disease (PD) remains to be further elucidated the early stages disease. Eighty-six less than 5 years onset PD were retrospectively enrolled study. We assessed potential risk including (1) a history falls during past year (faller versus non-faller), (2) fear falling (FoF), and (3) freezing gait (FoG). Different types NMSs measured using Montreal Cognitive Assessment (MoCA), Beck Depression...
Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) 18 F‐fluorodeoxyglucose positron emission tomography ( F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with (16 probable 8 possible) eight PD were included this study. Results: For analysis using putaminal findings, sensitivities...
Objective Elevation of C reactive protein (CRP) is one the major acute-phase responses following ischaemic or haemorrhagic stroke. This study aims to investigate associations between platelet indices, neutrophil-to-lymphocyte ratio (NLR) and erythrocyte sedimentation rate (ESR) compared with CRP in patients cerebral infarction. Setting The clinical data infarction were analysed retrospectively. Participants We analysed, unduplicated, 516 (mean age 66.2±12.7, male/female=291/225). Outcome...
Recent evidence has revealed an association between neurodegenerative disorders and olfactory dysfunction. However, whether training can improve cognitive impairment in patients with dementia requires further study. The present study aimed to resolve this by developing intensive (IOT) protocol assessing its impact on each of the domains dementia.Patients were prospectively recruited June 2020 September 2020. Baseline evaluations included demographic data, function test, depression scale...
Aim Clinical implications for motor phenotypes of Parkinson's disease (PD) remain to be further elucidated, particularly at the early stages disease. We aimed compare non‐motor and fall‐related features between tremor‐dominant (TD) postural instability‐gait difficulty (PIGD) subtypes in patients with PD. Methods PD was categorized into TD, intermediate PIGD types, according literature. Not only symptoms, but also symptoms global cognition, depression, anxiety, fatigue dysautonomia, were...
Postural instability and gait disturbance are the cardinal symptoms associated with falling among patients Parkinson's disease (PD). The Tinetti mobility test (TMT) is a well-established measurement tool used to predict falls elderly people. However, TMT has not been established or widely PD in Korea. purpose of this study was evaluate reliability validity Korean version for patients.Twenty-four diagnosed were enrolled study. For interrater test, thirteen clinicians scored after watching...
This is the first prospective cohort study of Huntington's disease (HD) in Korea. aimed to investigate caregiver burden relation characteristics patients and caregivers.