A5102924592- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Foot and Ankle Surgery
- Neurogenesis and neuroplasticity mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Intracranial Aneurysms: Treatment and Complications
- Advancements in Battery Materials
- Vestibular and auditory disorders
- Neurological disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Parkinson's Disease Mechanisms and Treatments
- Tendon Structure and Treatment
- Advanced Battery Materials and Technologies
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Lower Extremity Biomechanics and Pathologies
- Phagocytosis and Immune Regulation
- Flavonoids in Medical Research
- Nuclear Receptors and Signaling
- Pancreatic and Hepatic Oncology Research
Korea Brain Research Institute
2019-2025
University of Seoul
2021
Material Measurement Laboratory
2013-2015
National Institute of Standards and Technology
2013-2015
University of Ulsan
2000-2014
Asan Medical Center
2000-2014
Ulsan College
2008-2014
Kyung Hee University
2014
Korea University
2011-2013
Sungkyunkwan University
2013
Although there have been attempts to make clinical-MRI correlation in patients with lateral medullary infarction (LMI), studies a large number of are unavailable. In this study, clinical features, MRI findings and angiogram results 130 acute, consecutive pure LMI were studied correlated. MRI-identified lesions classified rostro-caudally as rostral, middle caudal, horizontally typical, ventral, large, dorsal. The distribution horizontal subtypes was significantly different (P <0.001) among...
Background and purpose Along with intracranial atherosclerotic disease ( ICAD ), moyamoya MMD ) is the most common cause of middle cerebral artery MCA occlusion in Asians. Although they have differing vascular wall pathologies, conventional angiographic evaluation methods cannot easily differentiate from certain situations, such as young patients risk factors. High resolution magnetic resonance imaging HR ‐ MRI findings for diseased segments s symptomatic were compared to further elucidate...
Article1 March 2021Open Access Transparent process SGK1 inhibition in glia ameliorates pathologies and symptoms Parkinson disease animal models Oh-Chan Kwon orcid.org/0000-0002-6433-4507 Department of Biochemistry Molecular Biology, College Medicine, Hanyang University, Seoul, Korea Biomedical Research Institute, Graduate School Science Engineering, SeoulThese authors contributed equally to this work Search for more papers by author Jae-Jin Song KoreaThese Yunseon Yang Seong-Hoon Kim Seoul...
It is unknown whether the development of cerebral microbleeds (MBs), small areas signal loss on T2*-weighted gradient-echo imaging (GRE), follows a slow or rapid process. We hypothesized that MBs may develop rapidly after certain critical events, such as strokes, and investigated frequency, location, factors associated with formation new acute ischemic stroke.We retrospectively examined 237 consecutive stroke patients who underwent MRI within 24 hours follow-up during week symptom onset....
Background and purpose The progression pattern of brain structural changes in patients with isolated cerebrovascular disease ( CVD ) remains unclear. To investigate the role cognitive impairment patients, patterns cortical thinning hippocampal atrophy pure subcortical vascular mild (sv MCI dementia SV aD) were characterized. Methods Forty‐five sv 46 aD who negative on Pittsburgh compound B (PiB) positron emission tomography imaging 75 individuals normal cognition NC recruited. Results...
Microtubule-associated protein (MAP) 2 has been perceived as a static cytoskeletal enriched in neuronal dendritic shafts. Emerging evidence indicates dynamic functions for various MAPs activity-dependent synaptic plasticity. However, it is unclear how MAP2 associated with plasticity mechanisms. Here, we demonstrate that specific silencing of high-molecular-weight vivo abolished induction long-term potentiation (LTP) the Schaffer collateral pathway CA1 pyramidal neurons and vitro blocked...
This study was performed to determine whether pure cancellous bone graft and Kirschner (K-) wire fixation were sufficient achieve bony union restore alignment in scaphoid nonunion. A total of 65 patients who underwent K-wire included this study. The series 61 men four women with a mean age 34 years (15 72) delay surgery 28.7 months (3 240). divided into an unstable group (A) stable (B) depending on the pre-operative radiographs. Unstable nonunion defined as lateral intrascaphoid angle > 45°,...
In the adult brain, neural circuit homeostasis depends on constant turnover of synapses via astrocytic phagocytosis mechanisms. However, it remains unclear whether this process occurs in a circuit-specific manner. Here, we reveal that astrocytes target and eliminate specific type excitatory striatum. Using model mice lacking receptors dorsal striatum, found constantly remove corticostriatal rather than thalamostriatal synapses. This preferential elimination suggests play selective role...
Although bilateral subthalamic deep brain stimulation (STN DBS) provides greater relief from the symptoms of Parkinson's disease (PD) than unilateral STN DBS, it has been suggested that DBS may be a reasonable treatment option in selected patients, especially those with highly asymmetric PD. In previous studies on effect asymmetry PD was not prominent and mean follow-up durations were only 3 to 12 months. this study, we report our findings series 8 patients who treated followed for 24 Serial...
We studied 11 patients with checkrein deformities of the hallux who underwent surgical treatment. Six had lengthening flexor hallucis longus tendon by Z-plasty in midfoot, and five release adhesions at musculotendinous junction fracture site. All six midfoot showed complete correction deformity without recurrence. Of site, two partial one
We reviewed the results of a selective à la carte soft-tissue release operation for recurrent or residual deformity after initial conservative treatment idiopathic clubfoot by Ponseti method. Recurrent occurred in 13 (19 feet) 33 patients (48 feet; 40%). The mean age at surgery was 2.3 years (1.3 to 4) and follow-up 3.6 (2 5.3). Pirani score had improved from 2.8 1.1 points, clinical radiological were satisfactory all patients. However, six (9 19 required further form tibial derotation...
Although basilar artery atherosclerotic disease (BAD) is frequent in patients with pontine base infarction, it remains unknown whether BAD related to the lesion size or clinical outcome.We studied 56 unilateral infarction who underwent (i) diffusion-weighted MRI within 48 h after stroke onset and (ii) follow-up MR angiography subacute stage. Neurologic progression was defined as increased National Institutes of Health Stroke Scale score by > = 2 during admission. Clinical outcome...
Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) 18 F‐fluorodeoxyglucose positron emission tomography ( F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with (16 probable 8 possible) eight PD were included this study. Results: For analysis using putaminal findings, sensitivities...
Abstract Transverse boundaries divide the mammalian cerebellar cortex into transverse zones, and within each zone is further subdivided a symmetrical array of parasagittal stripes. This topography highly conserved across Mammalia. Bats have remarkable cerebellum with presumed adaptations to flight echolocation, but nothing known its compartmentation. We therefore used two Purkinje cell compartmentation antigens, zebrin II/aldolase C phospholipase Cβ4, reveal in microchiropteran bats. Three...
Neuronal migration and lamina-specific primary afferent projections are crucial for establishing spinal cord circuits, but the underlying mechanisms poorly understood. Here, we report that in mice lacking Dcc(deleted colorectal cancer), some early-born neurons could not migrate ventrally cord. Conversely, forced expression of Dcccaused ventral prevented dorsolateral late-born neurons. In superficial layer Dcc–/– mutants, mislocalized followed by proprioceptive afferents, while their presence...
Some patients develop major neurological complications after carotid revascularization procedures, despite the lack of new infarcts or classical hyperperfusion syndrome.In four who developed deficits but without evidence ischemic hyperperfusion, we performed post-procedural MRI [diffusion-weighted image (DWI), perfusion-weighted (PWI), pre-and post-contrast fluid-attenuated inversion recovery (FLAIR) image] immediately and 1 day procedure.Post-gadolinium FLAIR images on procedures showed...
We reviewed the outcome of distal chevron metatarsal osteotomy without tendon transfer in 19 consecutive patients (19 feet) with a hallux varus deformity following surgery for valgus. All underwent medial displacement and closing wedge along capsular release. The mean valgus angle improved from -11.6° pre-operatively to 4.7° postoperatively, first-second intermetatarsal -0.3° 3.3° articular 9.5° 2.3° first metatarsophalangeal joints became congruent post-operatively all feet. relative length...
The association between past stroke subtypes and recurrent in non-cardiogenic remains unknown.Patients with ischaemic who had a history of large-artery disease (LAD) or small-artery (SAD) were assessed. LAD was subdivided into intracranial atherosclerosis (ICAS) extracranial (ECAS). mechanisms categorized as artery-to-artery embolism, situ thrombotic occlusion local branch occlusion, while SAD lacunar infarction (LI) atheromatous (BAD) on the basis magnetic resonance imaging findings....
Background and purpose: Lateral thalamic infarction (LTI) is usually caused by small vessel disease (SVD), i.e., occlusion of the deep perforator. However, focal atherosclerotic posterior cerebral artery (PCAD) may produce LTI via thrombotic We aimed to investigate prevalence PCAD in differences clinical imaging findings between LTIs associated with SVD. Methods: retrospectively evaluated 58 consecutive patients isolated who underwent diffusion‐weighted (DWI) MR angiography (MRA) within 7...
Objectives Specific guidelines for initial dosing of warfarin in ischaemic stroke patients have not been developed. Therefore, we developed an age‐ and weight‐adjusted initiation nomogram ( AW ‐ WIN ) then evaluated the efficacy safety compared with physician‐determined PDWD ). Methods The was administered to 104 acute between January 2008 February 2009. A historical control group 96 selected from comparable who were discharged during previous year. Time‐to‐therapeutic international...
Microglia-mediated inflammation is a major pathological mechanism contributing to Alzheimer’s disease (AD), and has been proposed as potential therapeutic target. Chunghyuldan (CHD; Qingxue-dan in Chinese Daio-Orengedokuto Japanese) possesses wide-ranging biological effects, including anti-hyperlipidemic, anti-stroke, anti-inflammatory, antioxidant activities that could affect neurological functions. In this study, we examined the effects of CHD in-vitro in-vivo models AD induced by...
LBA4032 Background: Currently, there is no standard regimen for palliative chemotherapy in metastatic, unresectable biliary tract cancer (BTC). A phase II trial of erlotinib monotherapy showed a promising anti-tumor activity BTC with tolerable toxicity. Additionally, gemcitabine + demonstrated superior efficacy when compared to alone pancreatic cancer. Hence, we conducted III compare between GEMOX vs GEMOX+erlotinib (Tarceva [T]) (GEMOX/T) as first-line unresectable, metastatic BTC. Methods:...