A5103058531- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Neurological and metabolic disorders
- Neurological Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Parkinson's Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Child Abuse and Related Trauma
- Traumatic Brain Injury and Neurovascular Disturbances
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Olfactory and Sensory Function Studies
- Herpesvirus Infections and Treatments
- Thermal Regulation in Medicine
- Biomedical Research and Pathophysiology
- Neonatal Respiratory Health Research
- Glycogen Storage Diseases and Myoclonus
- Facial Nerve Paralysis Treatment and Research
Soonchunhyang University Hospital
2017-2025
EuBiologics (South Korea)
2022-2024
Seoul National University
2024
Seoul National University Bundang Hospital
2020-2023
Seoul National University Hospital
2023
Soonchunhyang University
2015-2020
Ewha Womans University
2017-2018
Abstract Background Numerous vaccine strategies are being advanced to control SARS-CoV-2, the cause of COVID-19 pandemic. EuCorVac-19 (ECV19) is a recombinant protein nanoparticle that displays SARS-CoV-2 receptor-binding domain (RBD) on immunogenic nanoliposomes. Methods Initial study phase 2 randomized, observer-blind, placebo-controlled trial assess immunogenicity, safety, and tolerance ECV19 was carried out between July October 2021. Two hundred twenty-nine participants were enrolled at...
Background: Previous risk assessment tools for patients with atrial fibrillation (AF) have not primarily focused on those acute ischemic stroke (AIS). Prediction models that rely solely clinical parameters shown limited predictive ability, underscoring the need incorporate neuroimaging to improve prediction of recurrence in AIS AF. Method: The East-Asian Ischemic Stroke Patients Atrial Fibrillation (EAST-AF) study was a nationwide, multicenter prospective registry enrolled AF from 15...
Introduction: Current guidelines solely recommend optimal medical therapy including antiplatelet, lipid lowering, and antihypertensive treatment due to the unclear efficacy of stenting endarterectomy for symptomatic vertebral artery (VA) stenosis. However, incidence recurrent ischemic stroke(RIS) in VA steno-occlusion under real-world settings is not well established. This study aims assess RIS identify high-risk populations who might benefit from additional interventions among patients with...
The influence of duration type 2 diabetes mellitus (T2DM) on the likelihood developing new-onset dementia in post-stroke population is not well understood. Therefore, we aimed to clarify relationship between T2DM and risk population. Leveraging Korean National Health Insurance Database, this study included 118,790 individuals with a history stroke but no previous diagnosis. We classified status into five categories: normoglycemia, impaired fasting glucose (IFG), newly diagnosed T2DM,...
Abstract EuCorVac‐19 (ECV‐19) is a recombinant receptor binding domain (RBD) COVID‐19 vaccine that displays the RBD (derived from SARS‐CoV‐2 Wuhan strain) on immunogenic liposomes. This study compares safety and immunogenicity of ECV‐19 to COVISHIELD TM (CS) adenoviral‐vectored vaccine. Interim analysis presented randomized, observer‐blind, immunobridging Phase 3 trial in Philippines 2600 subjects, with treatment biospecimen collection between October 2022 January 2023. Healthy male female...
<b><i>Background:</i></b> There are only few studies exploring the relationship between white matter lesions (WMLs) and non-motor symptoms in Parkinson disease (PD). This study aimed to investigate association WMLs severity of PD. <b><i>Methods:</i></b> The motor dysfunction, cognitive impairment, was assessed by various scales 105 PD patients. We used a visual semiquantitative rating scale divided subjects into four groups: no, mild, moderate,...
Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in infants, young children, and the elderly. Two subtypes RSV, A B, circulate alternately at 1-2-year intervals during epidemics. The attachment glycoprotein (G protein) RSV one targets for immune responses. In this study, we generated recombinant fusion protein, GcfAB, which consists central regions (a.a. residues 131-230) G proteins both (A2 strain) B (B1 subtypes, investigated immunogenicity,...
Background Perfusion imaging (PI) serves as a valuable tool for triaging patients with acute ischemic stroke endovascular treatment (EVT). This study aims to investigate trends in PI use and its impacts on EVT rates clinical outcomes, particularly focusing variations across different time windows. Methods Data from prospective, nationwide, registry South Korea were analyzed retrospectively. was regarded treatment‐decision when conducted either (1) prior EVT, or (2) within 3 hours hospital...
Dopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in DAT iNPH patients remains be further elucidated.In this preliminary study, 11 with our hospital between March 2017 and February 2019 were finally enrolled. A diagnosis was made according the two established criteria. For visual analysis imaging, striatum divided into five domains....
It is controversial that decreased left ventricular function could predict poststroke outcomes. The purpose of this study to elucidate whether ejection fraction (LVEF) can cardiovascular events and mortality in acute ischemic stroke (AIS) without atrial fibrillation (AF) coronary heart disease (CHD).Transthoracic echocardiography was conducted consecutively patients with AIS or transient attack at Soonchunhyang University Hospital between January 2008 July 2016. clinical data...
Background: Korea recently established 70 emergency medical service areas. However, there are many concerns that resources for stroke could not be evenly distributed through the country. We aimed to compare treatment quality and outcomes of acute among areas.Methods: This study analyzed data 28,800 patients admitted in 248 hospitals which participated 8th assessment by Health Insurance Review Assessment Service. Individual were regrouped into areas according address location. indicators...
There is limited information on the delivery of acute stroke therapies and secondary preventive measures clinical outcomes over time in young adults with ischemic stroke. This study investigated whether advances these treatments improved this population.
Although recent studies have suggested that adherence to antihypertensive treatment reduced stroke incidence, the relationship of antihypertensives with severity has not been studied. This study attempted know whether nonadherence before is associated initial acute ischemic stroke.Consecutive patients were identified in Soonchunhyang University Hospital from Mar 2005 Aug 2014, excluding cases without hypertension or information adherence. We compared mean National Institute Health Stroke...
Antigenic variation in viral surface antigens is a strategy for escaping the host's adaptive immunity, whereas regions with pivotal functions infection are less subject to antigenic variability. We hypothesized that genetically invariable and immunologically dormant of antigen could be exposed host immune system activated by rendering them susceptible antigen-processing machinery professional antigen-presenting cells (APCs). Considering frequent drift shift influenza viruses, we identified...
Cutting balloon-percutaneous transluminal angioplasty (CB-PTA) is a feasible treatment option for in-stent restenosis (ISR) after carotid artery stenting (CAS). However, the longterm durability and safety of CB-PTA ISR CAS have not been well established.
A 61-year-old woman with chronic kidney disease presented general weakness and a confused mentality. Two days before admission she had been diagnosed as Bell's palsy at an outpatient clinic, started to take oral prednisolone acyclovir. blood test revealed hyponatremia (128 mmol/L). After withdrawing acyclovir, her plasma sodium levels began increase, returning normal 2 weeks later. This case could provide further evidence for causal relationship between acyclovir hyponatremia. Key Words:...
Primary Epstein-Barr virus (EBV) infection can manifest with a broad spectrum of neurological complications. There are only rare reports Guillain-Barré syndrome (GBS) supervening on meningitis in patients primary EBV infection. Clear evidence central nervous system in-fection makes it difficult for the clinicians to consider diagnosis GBS. We present patient GBS