A5100719141- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Nutritional Studies and Diet
- Cancer Mechanisms and Therapy
- Hepatitis C virus research
- Dementia and Cognitive Impairment Research
- Ferroptosis and cancer prognosis
- Liver Diseases and Immunity
- Heavy Metal Exposure and Toxicity
- Nutrition and Health in Aging
- Colorectal Cancer Treatments and Studies
- Anesthesia and Sedative Agents
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Spine and Intervertebral Disc Pathology
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Intensive Care Unit Cognitive Disorders
- Trace Elements in Health
Hallym University
2010-2025
Chuncheon Sacred Heart Hospital
2010-2025
Catholic University of Korea
2019-2024
Seoul St. Mary's Hospital
2021-2024
Yang Hospital
2022-2024
Indiana University School of Medicine
2023
Seoul National University Bundang Hospital
2023
Indiana University
2023
Indiana University – Purdue University Indianapolis
2023
Hallym University Medical Center
2021-2022
Background Fibromyalgia (FM) is a disorder characterized by chronic widespread pain and frequently associated with other symptoms. Patients FM commonly report cognitive complaints, including memory problem. The objective of this study was to investigate the differences in neural correlates working between patients healthy subjects, using functional magnetic resonance imaging (MRI). Methodology/Principal Findings Nineteen 22 subjects performed an n-back task during MRI scan. Functional data...
Background and Objectives: Recent research has focused on exploring the relationships between various factors associated with headaches understanding their impact individuals’ psychological states. Utilizing statistical methods machine learning models, these studies aim to analyze predict develop effective approaches for headache management prevention. Materials Methods: Analyzing data from 398 patients (train set = 318 test 80), we investigated influence of features outcomes such as...
The influence of duration type 2 diabetes mellitus (T2DM) on the likelihood developing new-onset dementia in post-stroke population is not well understood. Therefore, we aimed to clarify relationship between T2DM and risk population. Leveraging Korean National Health Insurance Database, this study included 118,790 individuals with a history stroke but no previous diagnosis. We classified status into five categories: normoglycemia, impaired fasting glucose (IFG), newly diagnosed T2DM,...
<sec> <title>BACKGROUND</title> The risk of developing atherosclerotic cardiovascular disease (ASCVD) varies among individuals and is related to a variety lifestyle factors in addition the presence chronic diseases. </sec> <title>OBJECTIVE</title> We aimed assess predictive accuracy machine learning (ML) models incorporating behaviors for ASCVD using Korean nationwide database. <title>METHODS</title> Utilizing data from Korea National Health Nutrition Examination Survey, five ML algorithms...
Background/Aims: Lenvatinib was recently approved as a first-line oral multikinase inhibitor for unresectable hepatocellular carcinoma (HCC). In this study, we aimed to compare the efficacy and safety of lenvatinib sorafenib treatment HCC in patients with prior failure transarterial treatment. Methods: Between January 2019 September 2020, 98 treated or salvage therapy were enrolled from five Korean university-affiliated hospitals. Progression-free survival (PFS), overall (OS), objective...
Non-alcoholic fatty liver disease (NAFLD) has become a major concern in Korea since its emergence as dominant cause of chronic disease. However, no study explored prevalence adults under 30 years age. Therefore, we performed cross-sectional to investigate the NAFLD Korean men their early 20s.We collected data 596,359 soldiers who participated health examination between January 2015 and July 2021. A total 571,872 individuals were analyzed after excluding those with missing hepatitis B antigen...
Abstract Background Immune checkpoint inhibitors (ICIs) cause thyroid immune-related adverse effects (irAEs). However, associations between each type of effect (irAE) and the anti-tumor ICI remains unknown. This study aimed to determine dysfunction on patient survival. Methods Patients who initiated treatment from January 2015 December 2019 in Seoul St. Mary’s Hospital were retrospectively analyzed. Thyroid was classified into four types: newly developed overt or subclinical hypothyroidism,...
Real-world results of nivolumab monotherapy against HCC are lacking in the hepatitis B virus (HBV)-endemic, Asia-Pacific regions. Moreover, heterogeneous responses to immune checkpoint inhibitors have rarely been described advanced HCC. The aim this study is evaluate efficacy and safety a real-world setting 33 Korean patients with unresectable In our cohort, twenty-nine (88%) showed HBsAg positivity. At time initiation, 4 among (12%) were classified as Barcelona Clinic Liver Cancer (BCLC)-B...
Although cigarette smoking has been associated with an increased risk of hepatocellular carcinoma (HCC), its association HCC mortality remains underexplored. We aimed to evaluate the effect on early in patients following curative treatment.
Background: Magnetic resonance imaging (MRI) has been used to diagnose sinus tarsi syndrome (STS) because of its non-invasiveness and accuracy. The purpose the present study was evaluate diagnostic efficiency MRI compared with subtalar arthroscopy for STS. Materials Methods: Twenty-eight patients (30 feet) who had undergone both STS were evaluated. results arthroscopic findings, which considered standard. Sensitivity, specificity, positive negative predictive values calculated, correlations...
The comparative efficacy and safety between lenvatinib hepatic artery infusion chemotherapy (HAIC) in patients with unresectable hepatocellular carcinoma (HCC) is still unclear. This multicenter historical cohort study enrolled 244 who were treated HAIC (n = 173) or 71) 2012 2020. Propensity score matching (PSM) was performed, 52 selected per group. Clinical outcomes compared. Objective response rate (ORR) not different the two groups (26.0% vs. 23.1%, p 0.736). Before PSM, group had a...
Background and Aims: Intrahepatic mononuclear phagocytes (MPs) are critical for the initiation progression of liver fibrosis. In this study, using multiplexed digital spatial protein profiling, we aimed to derive a unique signature predicting advanced Methods: Snap-frozen tissues from various chronic diseases were subjected spatially defined protein-based profiling (Nanostring GeoMXTM). A single-cell RNA sequencing analysis was performed Gene Expression Omnibus (GEO) datasets normal...
Clustering lifestyle risk behaviors is important for predicting cardiovascular disease risk. However, it unclear which behavior mediates other ones to influence We aimed assess the causal inference of each atherosclerotic (ASCVD) general population.
This study aims to evaluate the real-world effectiveness of regdanvimab on clinical outcomes in patients with mild moderate coronavirus disease 2019 (COVID-19).
Hemorrhagic transformation (HT) is one of the leading causes a poor prognostic marker after acute ischemic stroke (AIS). We compared performances several machine learning (ML) algorithms to predict HT AIS using only structured data. A total 2028 patients with AIS, who were admitted within seven days symptoms onset, included in this analysis. was defined based on criteria European Co-operative Acute Stroke Study-II trial. The whole dataset randomly divided into training and test 7:3 ratio....
Thyroid-stimulating immunoglobulin (TSI) bioassay has a better ability to predict the relapse rate of Graves' disease (GD) than thyroid-stimulating hormone (TSH)-binding inhibitory method in terms measuring TSH receptor antibody. However, optimal TSI cutoff for predicting after antithyroid drug (ATD) withdrawal is not well evaluated.This retrospective study enrolled GD patients who had been treated with ATD and obtained their <140% from January 2010 December 2019 referral hospital.Among 219...
<b><i>Introduction:</i></b> Despite the emergence of atezolizumab and bevacizumab (A + B) as standard first-line systemic therapy for unresectable hepatocellular carcinoma (HCC), a comprehensive understanding clinical significance immune-related adverse events (irAEs) remains limited. We aimed to assess impact irAEs on patients with HCC undergoing A B treatment. <b><i>Methods:</i></b> This multicentre retrospective study included consecutive...
Background and Objectives: For preventing postoperative delirium (POD), identifying the risk factors is important. However, relationship between blood transfusion POD still controversial. The aim of this study was to identify POD, evaluate impact in developing among people undergoing spinal fusion surgery, show effectiveness big data analytics using a clinical warehouse (CDW). Materials Methods: medical patients who underwent surgery were obtained from CDW five hospitals Hallym University...
Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder influenced by various factors, including liver function, which may impact the clearance of amyloid-β (Aβ) in brain. This study aimed to explore how apolipoprotein E ( APOE ) ε4 allele affects relationship function markers with AD pathology and cognition. Methods We analyzed data from two independent cohorts, 732 participants Hallym University Medical Center 483 Disease Neuroimaging Initiative, each group consisting...
This study develops a predictive model for video laryngoscopic views using advanced machine learning techniques, aiming to enhance airway management's efficiency and safety. A total of 212 participants were involved, with 169 in the training set 43 test set. We assessed outcomes percentage glottic opening (POGO) score considered factors like modified Mallampati classification, thyromental height distance, sternomental mouth neck circumference. range algorithms was employed data analysis,...