A5024859367- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Bioinformatics and Genomic Networks
- Neurological Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Lower Extremity Biomechanics and Pathologies
- Vascular Malformations Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Diet and metabolism studies
- Neurological Disorders and Treatments
- Functional Brain Connectivity Studies
- Trigeminal Neuralgia and Treatments
- Folate and B Vitamins Research
- Neurosurgical Procedures and Complications
- Bipolar Disorder and Treatment
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Migraine and Headache Studies
Hallym University
2023-2025
Chuncheon Sacred Heart Hospital
2023-2025
Soonchunhyang University Hospital
2023-2025
National University College
2023
Indiana University
2023
Indiana University – Purdue University Indianapolis
2023
Indiana University School of Medicine
2023
University School
2023
Rush University Medical Center
2023
Seoul National University Bundang Hospital
2020-2023
Abstract Background Alzheimer’s dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and machine learning analysis of miRNA can provide insights into AD pathology prognostic/diagnostic biomarkers. Methods We performed co-expression to identify modules associated with AD, its neuropathology markers, cognition using brain tissue profiles from the Religious Orders Study Rush Memory Aging Project (ROS/MAP) ( N = 702) as a discovery...
Abstract INTRODUCTION The molecular mechanisms underlying early‐onset Alzheimer's disease (EOAD) and late‐onset (LOAD) remain incompletely understood, particularly in Asian populations. METHODS RNA‐sequencing was carried out on blood samples from 248 participants the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) weighted co‐expression network analysis. Findings were replicated an independent Korean ( N = 275). RESULTS DGE analysis identified...
Multiple animal models of migraine have been used to develop new therapies. Understanding the transition from episodic (EM) chronic (CM) is crucial. We established mimicking EM and CM pain assessed neuropathological differences. were induced with single NTG or multiple injections over 9 days. Mechanical hypersensitivity was assessed. Immunofluorescence utilized c-Fos, NeuN, Iba1. Proinflammatory anti-inflammatory markers analyzed. Neuropeptides (CGRP, VIP, PACAP, substance P) thresholds...
Diabetes mellitus (DM) predisposes individuals to vascular injury, leading poor outcomes after ischemic stroke and symptomatic hemorrhagic transformation (SHT) thrombolytic endovascular treatment (EVT). Metformin (MET), an oral antidiabetic drug, has shown potential neuroprotective effects, but its impact on prognosis in DM patients undergoing EVT remains unclear. In a multicenter study, 231 with for acute were enrolled. Prior MET use was identified, stratified into MET+ MET− groups....
Purpose: Among other emerging amyloid-targeting blood-based biomarkers, Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) measures dynamic changes in concentration of oligomeric amyloid-β (OAβ), which is considered the main pathogenic culprit Alzheimer’s disease (AD), plasma after spiking with synthetic (Aβ). We aimed to investigate predictability MDS-OAβ on amyloid positron emission tomography (PET) positivity. Patients and Methods: A total 96 subjects who visited Seoul National...
Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder influenced by various factors, including liver function, which may impact the clearance of amyloid-β (Aβ) in brain. This study aimed to explore how apolipoprotein E ( APOE ) ε4 allele affects relationship function markers with AD pathology and cognition. Methods We analyzed data from two independent cohorts, 732 participants Hallym University Medical Center 483 Disease Neuroimaging Initiative, each group consisting...
This study aimed to investigate the association between cerebral small vessel disease (CSVD) burden and infarct growth rate (IGR) in patients with large occlusion (LVO) stroke who underwent endovascular treatment (EVT). A retrospective analysis was conducted on a cohort of 495 anterior circulation received EVT. CSVD assessed using score based neuroimaging features. IGR calculated from diffusion-weighted imaging (DWI) lesion volumes divided by time onset imaging. Clinical outcomes included...
Idiopathic normal pressure hydrocephalus (iNPH) is characterized by the classic triad of gait disturbance, urinary incontinence, and cognitive impairment in presence ventriculomegaly without known risk factors for communicating hydrocephalus.
Abstract Background The tendency of amyloid-β to form oligomers in the blood as measured with Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) is a valuable biomarker for Alzheimer’s disease and has been verified heparin-based plasma. objective this study was evaluate performance ethylenediaminetetraacetic acid (EDTA)-based MDS-OAβ develop machine learning algorithms predict amyloid positron emission tomography (PET) positivity. Methods EDTA-based predicting PET positivity evaluated...
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) plaque accumulation and neurofibrillary tangles in the brain. Emerging evidence has suggested potential interactions between brain periphery, particularly liver, regulating Aβ homeostasis. This study aimed to investigate association of serum liver enzymes with amyloidopathy cognitive performance patients complaints decline. A total 1,036 (mean age 74 years, 66.2% female) subjective decline, mild impairment, AD dementia, other...
Abstract A synaptic protein, Neuronal Pentraxin 2 (NPTX2), has emerged as a pivotal biomarker for Alzheimer's dementia (AD). We identified candidate miRNAs targeting NPTX2 and performed association mediation analyses using multi‐omics data (N = 702). Among 44 miRNAs, miR‐133b was significantly associated with AD Braak positivity. Higher expression also higher gene better cognition. Mediation analysis showed that partially influences cognition through the protein. Our integrated approach...
Background: Integrative network and machine learning analysis of microRNA (miRNA) can provide insights into Alzheimer's dementia (AD) pathology prognostic/diagnostic biomarkers.Methods: We performed co-expression to identify modules associated with AD, neuropathology markers, cognition using brain tissue miRNA profiles from the Religious Orders Study Rush Memory Aging Project (ROS/MAP) (N=702) as a discovery dataset. association hub miRNAs cognition. For replication, we consensus ROS/MAP...
Alzheimer's dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and machine learning analysis of miRNA can provide insights into AD pathology prognostic/diagnostic biomarkers.
<title>Abstract</title> <bold>Background</bold>Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) plaque accumulation and neurofibrillary tangles in the brain. Emerging evidence has suggested potential interactions between brain peripheral organs, particularly liver, regulating Aβ homeostasis. This study aimed to investigate association of serum liver enzymes with amyloidopathy cognitive performance as precise relationship remains unclear.<bold>Methods</bold>This retrospective...
<title>Abstract</title> <bold>Background</bold>Alzheimer’s disease (AD) is a complex neurodegenerative disorder influenced by various factors, including liver function, which may impact the clearance of amyloid-β (Aβ) in brain. This study aimed to explore how apolipoprotein E (<italic>APOE</italic>) ε4 allele, well-known genetic risk factor for AD, affects relationship function markers with AD pathology and cognition.<bold>Methods</bold>Using two independent cohorts, Hallym University...
Foot drop can have a variety of causes, including the common peroneal nerve (CPN) injuries, and is often difficult to diagnose. We aimed develop deep learning-based algorithm that classify foot with CPN injury in patients knee MRI axial images only. In this retrospective study, we included 945 MR image data from confirmed electrophysiologic tests (n = 42), 1341 non-traumatic pain 107). Data were split into training, validation, test datasets using 8:1:1 ratio. used convolution neural...
Dear Editor,Nystagmus may be classified into jerky or pendular according to the presence of quick phases.In a single patient with acquired nystagmus is almost always either pendular.To best our knowledge, only few cases combined and involving different axes rotation have been described in patients central myelin disorders.Moreover, no correlation between patterns involved structures has reported. 1We report upbeat horizontal-torsional nystagmus.This suggests mechanisms for generating ocular...
Abstract Background: The tendency of amyloid-β oligomer (AβO) formation in the blood, measured with Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ), is a valuable biomarker for Alzheimer’s disease (AD), which has been verified using heparin-based plasma. objective this study was to evaluate performance ethylenediaminetetraacetic acid (EDTA)-based MDS-OAβ and develop machine learning algorithms predict amyloid positron emission tomography (PET) positivity. Methods: EDTA-based...