A5045089125- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Global Cancer Incidence and Screening
- Digital Radiography and Breast Imaging
- Gut microbiota and health
- AI in cancer detection
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Glaucoma and retinal disorders
- Liver Disease Diagnosis and Treatment
- Cancer Risks and Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cognitive Abilities and Testing
- Retinal Diseases and Treatments
- Alcohol Consumption and Health Effects
- Bone health and osteoporosis research
- T-cell and B-cell Immunology
- Nutrition, Genetics, and Disease
- Cardiovascular Disease and Adiposity
- Air Quality and Health Impacts
- Retinal Imaging and Analysis
- Health, Environment, Cognitive Aging
Seoul National University
2016-2025
Korea Environment Institute
2024
Samsung Medical Center
2005-2022
Sungkyunkwan University
2005-2022
Seoul National University Hospital
2011-2020
The University of Melbourne
2020
Child Health and Development Institute
2018
Icahn School of Medicine at Mount Sinai
2018
University of Chicago
2012
Kangbuk Samsung Hospital
2010
<h3>Objective</h3> Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in metabolism, current knowledge on effect of genetics specific microbes related to MetS status remains limited. Here, we investigated links among factors, humans. <h3>Design</h3> We characterised microbial community composition 655 monozygotic (n=306) dizygotic (n=74) twins their families...
Human papillomavirus (HPV) is the most important causative agent of cervical cancers worldwide. However, our understanding how vaginal microbiota might be associated with HPV infection limited. In addition, influence human genetic and physiological factors on unclear. Studies twins their families provide ideal settings to investigate complicated nature microbiota. This study investigated 68 HPV-infected or uninfected female using 454-pyrosequencing analysis targeting variable region (V2–V3)...
Obesity and type 2 diabetes (T2D) are linked both with host genetics environmental factors, including dysbioses of the gut microbiota. However, it is unclear whether these microbial changes precede disease onset. Twin cohorts present a unique genetically-controlled opportunity to study relationships between lifestyle factors microbiome. In particular, we hypothesized that family-independent in composition metabolic function during sub-clinical state T2D could be either causal or early...
<h3>Abstract</h3> <b>Objective</b> To investigate risk factors, such as heavy alcohol consumption, that might explain any increased of haemorrhagic stroke associated with low blood cholesterol. <b>Design</b> Prospective cohort study. <b>Setting</b> Korea. <b>Participants</b> 787 442 civil servants (661 700 men, 125 742 women) aged 30-64. <b>Main outcome measures</b> Cardiovascular factors were assessed at biennial health check. Data on morbidity and mortality ascertained from 1990 to 2001...
Purpose To estimate the current cancer burden in Korea, newly diagnosed cases and incidence rates were calculated for years 2003~2005. Materials Methods The from Korea National Cancer Incidence Database. Crude age-standardized by gender specified sites 5-year age groups. Results From 2003 to 2005, 398,824 of (218,856 men 179,968 women). For all combined, crude rate (CR) was 300.0 248.2 women (ASR) 297.0 191.2 per 100,000, respectively. Among men, five leading cancers stomach (CR 66.0, ASR...
Studies on the human gut microbiota have suggested that individuals could be categorized into enterotypes based compositions of their microbial communities. Here, we report healthy Koreans are clustered two enterotypes, dominated by either Bacteroides (enterotype 1) or Prevotella 2). More than 72% paired fecal samples from monozygotic twin pairs were assigned to same enterotype. Our longitudinal analysis these twins indicated more 80% belonged enterotype after about a 2-year interval....
Improvements in mobile telecommunication technologies have enabled clinicians to collect patient-reported outcome (PRO) data more frequently, but there is as yet limited evidence regarding the frequency with which PRO can be collected via smartphone applications (apps) breast cancer patients receiving chemotherapy.The primary objective of this study was determine feasibility an app for sleep disturbance-related collection from chemotherapy. A secondary identify variables associated better...
Abstract Human personality is 30–60% heritable according to twin and adoption studies. Hundreds of genetic variants are expected influence its complex development, but few have been identified. We used a machine learning method for genome-wide association studies (GWAS) uncover genotypic–phenotypic networks environmental interactions. The Temperament Character Inventory (TCI) measured the self-regulatory components critical health (i.e., character traits self-directedness, cooperativeness,...
Background: High-sensitivity C-reactive protein (hs-CRP) is a commonly used inflammatory marker. The association between hs-CRP and cancer less consistent than that cardiovascular diseases. This study explored the cancer, using large database of Korean health examination records.Methods: A total 80 781 Koreans who visited promotion center general hospital were included. There 729 cases any primary site during 3-year period. Subjects with known or condition capable affecting excluded.Results:...
Abstract We investigated the heritability of educational attainment and how it differed between birth cohorts cultural–geographic regions. A classical twin design was applied to pooled data from 28 representing 16 countries including 193,518 twins with information on at 25 years age or older. Genetic factors explained major part individual differences in (heritability: a 2 = 0.43; 0.41–0.44), but also environmental variation shared by co-twins substantial (c 0.31; 0.30–0.33). The proportions...
Abstract Experimental studies of learning suggest that human temperament may depend on the molecular mechanisms for associative conditioning, which are highly conserved in animals. The main genetic pathways conditioning known experimental animals, but have not been identified prior genome-wide association (GWAS) temperament. We used a data-driven machine method GWAS to uncover complex genotypic–phenotypic networks and environmental interactions related In discovery sample 2149 healthy Finns,...
Several recent studies showed that next-generation sequencing (NGS)-based human leukocyte antigen (HLA) typing is a feasible and promising technique for variant calling of highly polymorphic regions. To date, however, no method with sufficient read depth has completely solved the allele phasing issue. In this study, we developed new (HLAscan) HLA genotyping using NGS data.HLAscan performs alignment reads to sequences from international ImMunoGeneTics project/human (IMGT/HLA) database. The...
Phylogenetic, developmental, and brain-imaging studies suggest that human personality is the integrated expression of three major systems learning memory regulate (1) associative conditioning, (2) intentionality, (3) self-awareness. We have uncovered largely disjoint sets genes regulating these dissociable processes in different clusters people with unregulated temperament profiles (i.e., associatively conditioned habits emotional reactivity), organized character intentional self-control...
Weight loss and exercise intervention have been reported to increase the interaction between Bacteroides spp Akkermansiamuciniphila (Am), although underlying mechanisms consequences of remain unknown.Using a healthy Korean twin cohort (n = 582), we analyzed taxonomic associations with host body mass index. B vulgatus strains were isolated from mice human subjects investigate strain-specific effect SNUG 40005 (Bvul) on obesity. The Am enrichment by Bvul administration investigated multiple...
Abstract INTRODUCTION The molecular mechanisms underlying early‐onset Alzheimer's disease (EOAD) and late‐onset (LOAD) remain incompletely understood, particularly in Asian populations. METHODS RNA‐sequencing was carried out on blood samples from 248 participants the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) weighted co‐expression network analysis. Findings were replicated an independent Korean ( N = 275). RESULTS DGE analysis identified...
The purpose of this study was to analyze the position conus medullaris and Tuffier's line in same patient population, correlate with age sex, determine an objective guide for selection a safe intervertebral space during spinal block.Magnetic resonance imaging studies lumbar spine were reviewed 690 consecutive patients. population consisted patients older than 20 yr who had been referred assess possible causes low back pain. defined as most distal point cord that could be visualized on...
"Healthy Twin" is a twin family study extension of the existing Korean Twin-Family Register. Healthy Twin recruits adult like-sex twins over age 30 and their members. protocols are primarily tailored to quantitative trait loci complex traits as well role environment in etiology diseases. A full-length survey underway, including questionnaires, health examinations collection biological specimens. So far, 820 individuals (169 pairs families) have participated 1068 individual (608 pairs)...
To evaluate an association between obesity, measured by body mass index (BMI; kg/m(2)), and risk of cancer at individual all sites in postmenopausal women.A cohort 170,481 Korean women who were age 40 to 64 years baseline measurement BMI was observed prospectively from 1994 2003 for incidence. Multivariable adjusted proportional hazard models used evaluating the association.Women with a 30 kg/m(2) or higher had 23% than 21.0 22.9 (hazard ratio = 1.23; 95% CI, 1.08 1.41). According increase...
Cancer has been the most common cause of death in Korea since 1983 and is a major public health concern.This paper overviews nationwide cancer statistics, including incidence, mortality, survival rates, their trends Korea.In 2005, 142,610 new cases 65,117 deaths occurred Korea.The incidence rate for all combined increased by 2.6% annually from 1999 to 2005.Significant increases have colorectal, thyroid, female breast, prostate cancers.The number over past two decades, due mostly population...