A5063658112- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Alzheimer's disease research and treatments
- Peroxisome Proliferator-Activated Receptors
- Genetic Associations and Epidemiology
- Dementia and Cognitive Impairment Research
- Alcohol Consumption and Health Effects
- Epigenetics and DNA Methylation
- Lipid metabolism and biosynthesis
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Gene expression and cancer classification
- Biochemical Analysis and Sensing Techniques
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- GABA and Rice Research
- Computational Drug Discovery Methods
- Olfactory and Sensory Function Studies
- Mentoring and Academic Development
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Health and Medical Research Impacts
- Functional Brain Connectivity Studies
- Genetic Syndromes and Imprinting
Indiana University School of Medicine
2002-2025
Indiana University – Purdue University Indianapolis
2002-2025
Indiana University
2023
University School
2023
Rush University Medical Center
2023
Soonchunhyang University Hospital
2023
Seoul National University Bundang Hospital
2023
National University College
2023
New Generation University College
2023
Southeast Missouri State University
2018
Abstract INTRODUCTION The molecular mechanisms underlying early‐onset Alzheimer's disease (EOAD) and late‐onset (LOAD) remain incompletely understood, particularly in Asian populations. METHODS RNA‐sequencing was carried out on blood samples from 248 participants the Seoul National University Bundang Hospital cohort to perform differential gene expression (DGE) weighted co‐expression network analysis. Findings were replicated an independent Korean ( N = 275). RESULTS DGE analysis identified...
Deep learning is a promising tool that uses nonlinear transformations to extract features from high-dimensional data. challenging in genome-wide association studies (GWAS) with genomic Here we propose novel three-step approach (SWAT-CNN) for identification of genetic variants using deep identify phenotype-related single nucleotide polymorphisms (SNPs) can be applied develop accurate disease classification models. In the first step, divided whole genome into nonoverlapping fragments an...
Abstract Background Alzheimer’s dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and machine learning analysis of miRNA can provide insights into AD pathology prognostic/diagnostic biomarkers. Methods We performed co-expression to identify modules associated with AD, its neuropathology markers, cognition using brain tissue profiles from the Religious Orders Study Rush Memory Aging Project (ROS/MAP) ( N = 702) as a discovery...
Abstract INTRODUCTION The functional study of genetic risk factors for Alzheimer's disease (AD) provides insights into the underlying mechanisms and identification potential therapeutic targets. Investigating AD‐associated loci identified in East Asian populations using single‐nucleus RNA‐sequencing data may identify novel contributors. METHODS Cell type–specific expression quantitative trait (eQTL) peak‐to‐gene links were used to genes associated with 26 from seven genome‐wide association...
Selective breeding for high and low alcohol consumption led to the establishment of alcohol‐preferring (P) alcohol‐nonpreferring (NP) rat lines that differ greatly in their consumption. These were inbred F2 intercross progenies generated detect quantitative trait loci (QTLs) influencing A QTL on chromosome 4 was identified with a maximum lod score 8.6. This acts an additive fashion accounts 11% total phenotypic variability approximately one‐third genetic variability. Neuropeptide Y,...
Taste reactivity tests were used to examine the orofacial responses of alcohol preferring (P) rats and nonpreferring (NP) taste alcohol. In initial exposure, naive tested for five concentrations (5%, 10%, 20%, 30%, 40% v/v), water, one solution each sucrose quinine. A two‐bottle consumption test was then given a 3‐week period allow access 10% After preference test, second done using same solutions as in test. The results indicated no significant differences between P NP on except that made...
Analyzing disease-linked genetic variants via expression quantitative trait loci (eQTLs) is important for identifying potential disease-causing genes. Previous research prioritized genes by integrating Genome-Wide Association Study (GWAS) results with tissue- level eQTLs. Recent studies have explored brain cell type-specific eQTLs, but they lack a systematic analysis across various Alzheimer's disease (AD) GWAS datasets, nor did compare effects between tissue and type levels or different...
In the highly competitive environment of academic medicine, junior faculty investigators face high attrition rates due to challenges in finding effective mentorship, securing grant funding, and obtaining resources support their career development research productivity. The purpose this study was describe centralized, cost-sharing design Independent Investigator Incubator (I3) program as a novel approach mentoring evaluate quantitative outcomes for improvement. September 2014, I3 pilot...
The interaction between the brain and periphery might play a crucial role in development of Alzheimer's disease (AD).
BackgroundDeep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. This study introduces the Circular-Sliding Window Association Test (c-SWAT) improve classification accuracy predicting AD using serum-based metabolomics data, specifically lipidomics.MethodsThe c-SWAT methodology builds upon existing Sliding...
High alcohol drinking (HAD) and low (LAD) rats were tested, in three exposures, for taste reactivity to five concentrations of (5%, 10%, 20%, 30%, 40%, v/v), water, one concentration each sucrose quinine. Of the was done before a 3‐week period continuous access water 10% alcohol, second test immediately after consumption period, final 1 month abstinence. The results showed that groups did not differ on initial test. After tests (when HAD consumed significantly more than LAD rats),...
Naive, male rats ( n = 14) were given continuous access to 10% alcohol and water for a period of 6 weeks. Concurrent taste reactivity tests showed consistent increase in ingestive responding range concentrations (100%‐40%) over the course access. The also decrease aversive time. These data suggested that palatability increased with experience. After 1‐month abstinence, however, returned same level as found when naive, whereas approached seen initially. A separate control group 13) only...
Our previously developed blood-based transcriptional risk scores (TRS) showed associations with diagnosis and neuroimaging biomarkers for Alzheimer's disease (AD). Here, we brain-based TRS.