A5107965127- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cervical Cancer and HPV Research
- Lysosomal Storage Disorders Research
- Global Cancer Incidence and Screening
- Cholinesterase and Neurodegenerative Diseases
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Wnt/β-catenin signaling in development and cancer
- Genital Health and Disease
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Trypanosoma species research and implications
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Biology Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Reproductive tract infections research
- Metabolomics and Mass Spectrometry Studies
- Clinical practice guidelines implementation
- Biological Research and Disease Studies
- Computational Drug Discovery Methods
- Hepatitis B Virus Studies
- Medicinal Plants and Neuroprotection
- Axon Guidance and Neuronal Signaling
Centre International de Recherche sur le Cancer
2020-2025
BIOASTER
2017-2025
UK Dementia Research Institute
2024
University College London
2024
Denali Therapeutics (United States)
2019-2024
Alzheimer’s Disease Neuroimaging Initiative
2022-2023
University of California, San Francisco
2023
Indiana University – Purdue University Indianapolis
2023
Indiana University School of Medicine
2023
University Memory and Aging Center
2023
Passive immunization against β-amyloid (Aβ) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer9s disease (AD). However, traditional passive approaches carry the risk of Fcγ receptor-mediated overactivation microglial cells, which may contribute to inappropriate proinflammatory response leading vasogenic edema and cerebral microhemorrhage. Here, we describe generation humanized anti-Aβ monoclonal antibody IgG4 isotype, known MABT5102A (MABT). An subclass...
To evaluate the safety and efficacy of crenezumab in patients with mild to moderate Alzheimer disease (AD).In this phase 2 trial, 431 AD 50 80 years age were randomized 2:1 (crenezumab:placebo). Patients received low-dose subcutaneous 300 mg or placebo every weeks (n = 184) high-dose intravenous 15 mg/kg 4 247) for 68 weeks. Primary outcome measures change Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog12) Clinical Dementia Rating-Sum Boxes scores from baseline week 73.The...
The gap between chronological age (CA) and biological brain age, as estimated from magnetic resonance images (MRIs), reflects how individual patterns of neuroanatomic aging deviate their typical trajectories. MRI-derived (BA) estimates are often obtained using deep learning models that may perform relatively poorly on new data or lack interpretability. This study introduces a convolutional neural network (CNN) to estimate BA after training the MRIs 4,681 cognitively normal (CN) participants...
ONE approach to understanding the function of presenilin 1 (PS1), is discover those proteins with which it interacts. Evidence for a in developmental patterning came from C. elegans, PS homologue was identified by screening suppressors mutation Notch/lin-12, gene specifies cell fate. However, this genetic experiment cannot determine directly interact PS1. Therefore, we utilized two hybrid system and confirmatory co-immunoprecipitations identify novel catenin, termed β-catenin, interacts PS1...
We investigated the effect of crenezumab, a humanized anti-amyloid-beta (Aβ) immunoglobulin (Ig)G4 monoclonal antibody, on biomarkers amyloid pathology, neurodegeneration, and disease progression in patients with mild-to-moderate Alzheimer's (AD). This double-blind, placebo-controlled, randomized phase II study enrolled AD Mini-Mental State Examination (MMSE) score 18–26. In part 1 study, were 2:1 to receive low-dose subcutaneous (SC) 300 mg crenezumab every 2 weeks (q2w) or placebo for 68...
OBJECTIVES: The host response plays a central role in the pathophysiology of sepsis and severe injuries. So far, no study has comprehensively described overtime changes injury-induced immune profile large cohort critically ill patients with different etiologies. DESIGN: Prospective observational study. SETTING: Adult ICU University Hospital Lyon, France. PATIENTS: Three hundred fifty-three septic, trauma, surgical 175 healthy volunteers were included REAnimation Low Immune Status Marker...
Characterization of early tau deposition in individuals with preclinical Alzheimer disease (AD) is critical for prevention trials that aim to select at risk AD and halt the progression disease.To evaluate prevalence cortical positron emission tomography (PET) heterogeneity a large cohort clinically unimpaired older adults elevated β-amyloid (A+).This cross-sectional study examined prerandomized PET, amyloid structural magnetic resonance imaging, demographic, cognitive data from Anti-Amyloid...
Abstract The CanScreen5 project is a global cancer screening data repository that aims to report the status and performance of breast, cervical colorectal programs using harmonized set criteria indicators. Data collected mainly from Ministry Health in each country underwent quality validation ultimately became publicly available through Web-based portal. Until September 2022, 84 participating countries reported for breast ( n = 57), 75) or 51) repository. Substantial heterogeneity was...
Importance Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset (LOAD), but it remains unclear whether increased WMH along the AD continuum reflective of AD-intrinsic processes or secondary to elevated systemic vascular risk factors. Objective To estimate associations neurodegeneration parenchymal vessel amyloidosis with accumulation investigate associated beyond these...
Abstract Mechanisms of resilience against tau pathology in individuals across the Alzheimer’s disease spectrum are insufficiently understood. Longitudinal data necessary to reveal which factors relate preserved cognition (i.e. cognitive resilience) and brain structure despite abundant pathology, clarify whether these associations cross-sectional or longitudinal. We used a longitudinal study design investigate role several demographic, biological structural yielding as measured with PET. In...
Abstract Plasma phosphorylated-tau181 (p-tau181) showed the potential for Alzheimer’s diagnosis and prognosis, but its role in detecting cerebral pathologies is unclear. We aimed to evaluate whether it could serve as a marker pathology brain. A total of 1189 participants with plasma p-tau181 PET data amyloid, tau or FDG were included from ADNI. Cross-sectional relationships biomarkers tested. Longitudinally, we further investigated different levels at baseline predicted progression...
Abstract A biological research framework to define Alzheimer’ disease with dichotomized biomarker measurement was proposed by National Institute on Aging–Alzheimer’s Association (NIA–AA). However, it cannot characterize the hierarchy spreading pattern of tau pathology. To reflect in vivo progression using biomarker, we constructed a refined topographic 18 F-AV-1451 PET staging scheme longitudinal clinical validation. Seven hundred and thirty-four participants baseline (baseline age 73.9 ±...
The proportion of HPV16 and 18-associated cervical cancer (CC) appears rather constant worldwide (≥70%), but the relative importance other HR-HPV differs slightly by geographical region. Here, we studied HPV genotype distribution positive Latin American (LA) women histological grade, in a sub-cohort from ESTAMPA study; also explored association age-specific genotypes severe lesions. Cervical samples 1,252 participants (854 ≤CIN1, 121 CIN2, 194 CIN3 83 CC) were genotyped two PCRs-Reverse...
ABSTRACT Of the 12 HPV genotypes classified as carcinogenic to humans (Group 1), over 95% of HPV‐positive cervical cancers are linked eight (HPV16/18/31/33/35/45/52/58). Screening programmes may consider tests incorporating only these improve screening efficiency and reduce programmatic costs. Validation such requires fine‐tuning existing criteria. An expert group convened by International Agency for Research on Cancer discussed how criteria Meijer et al. clinical validation should be...
ONE approach to understanding the function of presenilin 1 (PS1), is discover those proteins with which it interacts. Evidence for a in developmental patterning came from C. elegans, PS homologue was identified by screening suppressors mutation Notch/lin-12, gene specifies cell fate. However, this genetic experiment cannot determine directly interact PS1. Therefore, we utilized two hybrid system and confirmatory co-immunoprecipitations identify novel catenin, termed γ-catenin, interacts PS1...
Government support for parallel development of AD therapeutics.
Introduction The host response to septic shock is dynamic and complex. A sepsis-induced immunosuppression phase has recently been acknowledged linked bad outcomes increased healthcare costs. Moreover, a marked suppression of the immune also partially described in patients hospitalized intensive care unit (ICU) for severe trauma or burns. It hypothesized that monitoring could enable identification who might most benefit from novel, adjunctive immune-stimulating therapies. However, there...
Abstract Neuroinflammation is associated with Alzheimer’s disease, but the application of cerebrospinal fluid measures inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 related to microglial T-cell functions, show them reproducibly form functionally-related groups within across diagnostic categories in 382 participants from Disease Neuro-imaging Initiative as well two independent cohorts. We further higher levels soluble...
delta-catenin is a member of the Armadillo repeat family and component adherens junction discovered in two-hybrid assay as bona fide interactor with presenilin-1 (Zhou et al., [1997], NeuroReport 8:2085-2090), protein which carries mutations that cause familial Alzheimer's disease. The expression pattern was mapped between embryonic day 10 (E10) adulthood by Northern blots, situ hybridization immunohistochemistry mouse. In development, dynamically regulated respect to its site expression. It...
Introduction Human papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV sensitivity, particularly low-income and middle-income countries (LMICs), where performance has been suboptimal. The ESTAMPA (EStudio multicéntrico de TAMizaje y triaje cáncer cuello uterino con pruebas...
BackgroundDeep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. This study introduces the Circular-Sliding Window Association Test (c-SWAT) improve classification accuracy predicting AD using serum-based metabolomics data, specifically lipidomics.MethodsThe c-SWAT methodology builds upon existing Sliding...