A5025091889- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Mitochondrial Function and Pathology
- Treatment of Major Depression
- Liver Disease Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- Metabolism and Genetic Disorders
- Mental Health Research Topics
- Stress Responses and Cortisol
- Peroxisome Proliferator-Activated Receptors
- Pharmacogenetics and Drug Metabolism
- Cholesterol and Lipid Metabolism
- Folate and B Vitamins Research
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Muscle metabolism and nutrition
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition, Genetics, and Disease
- Sphingolipid Metabolism and Signaling
Duke University
2016-2025
Duke Medical Center
2015-2024
Duke University Hospital
2011-2024
GGZ inGeest
2024
Vrije Universiteit Amsterdam
2024
Amsterdam University Medical Centers
2024
Helmholtz Zentrum München
2024
Arkansas State University
2024
Emory University
2014-2024
Ollscoil na Gaillimhe – University of Galway
2024
Huntington's disease (HD) is a progressive neurodegenerative illness for which there no effective therapy. We examined whether creatine, may exert neuroprotective effects by increasing phosphocreatine levels or stabilizing the mitochondrial permeability transition, has beneficial in transgenic mouse model of HD (line 6/2). Dietary creatine supplementation significantly improved survival, slowed development brain atrophy, and delayed atrophy striatal neurons formation huntingtin-positive...
Abstract Introduction Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and specific gut‐brain axis neurodegeneration. Bile acids (BAs), products of cholesterol metabolism clearance, are produced liver further metabolized by bacteria. They have major regulatory signaling functions seem dysregulated Alzheimer's disease (AD). Methods Serum levels 15 primary secondary BAs their conjugated forms were measured 1464 subjects including 370 cognitively...
Metabolomics is the comprehensive study of metabolome, repertoire biochemicals (or small molecules) present in cells, tissues, and body fluids. The metabolism at global or "-omics" level a rapidly growing field that has potential to have profound impact upon medical practice. At center metabolomics, concept person's metabolic state provides close representation individual's overall health status. This reflects what been encoded by genome, modified diet, environmental factors, gut microbiome....
The gene defect in Huntington's disease (HD) may result an impairment of energy metabolism. Malonate and 3-nitropropionic acid (3-NP) are inhibitors succinate dehydrogenase that produce depletion lesions closely resemble those HD. Oral supplementation with creatine or cyclocreatine, which substrates for the enzyme kinase, increase phosphocreatine (PCr) phosphocyclocreatine (PCCr) levels ATP generation thereby exert neuroprotective effects. We found oral either cyclocreatine produced...
Abstract Introduction The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, nonprofit organizations to develop new research directions transform our understanding disease (AD) propel the development critically needed therapies. In response their recommendations, big data at multiple levels are being generated integrated study network failures in disease. We used metabolomics as a global biochemical approach identify peripheral metabolic...
Background The metabolic basis of Alzheimer disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism AD pathogenesis are unclear. Understanding how global perturbations related to severity neuropathology eventual expression symptoms at-risk individuals critical developing effective disease-modifying treatments. In this study, we undertook parallel metabolomics analyses both brain blood identify correlates their associations with prodromal...
Background The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations ceramides sphingomyelins have been postulated to play a role amyloidogensis inflammatory stress related neuronal apoptosis; however few studies conducted comprehensive analysis the sphingolipidome AD using analytical platforms with accuracy, sensitivity reproducibility. Methods Findings We prospectively analyzed from 26 patients...
Bile acids (BAs) are the end products of cholesterol metabolism produced by human and gut microbiome co-metabolism. Recent evidence suggests microbiota influence pathological features Alzheimer's disease (AD) including neuroinflammation amyloid-β deposition.Serum levels 20 primary secondary BA metabolites from AD Neuroimaging Initiative (n = 1562) were measured using targeted metabolomic profiling. We assessed association BAs with "A/T/N" (amyloid, tau, neurodegeneration) biomarkers for AD:...
Large-scale untargeted lipidomics experiments involve the measurement of hundreds to thousands samples. Such data sets are usually acquired on one instrument over days or weeks analysis time. extensive acquisition processes introduce a variety systematic errors, including batch differences, longitudinal drifts, even instrument-to-instrument variation. Technical variance can obscure true biological signal and hinder discoveries. To combat this issue, we present novel normalization approach...
<h3>Importance</h3> Increasing evidence suggests an important role of liver function in the pathophysiology Alzheimer disease (AD). The is a major metabolic hub; therefore, investigating association with AD, cognition, neuroimaging, and CSF biomarkers would improve understanding dysfunction AD. <h3>Objective</h3> To examine whether markers are associated cognitive "A/T/N" (amyloid, tau, neurodegeneration) for <h3>Design, Setting, Participants</h3> In this cohort study, serum-based were...
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism. We analyze 2,114 post-mortem brain transcriptomes identify genes in alternative acid synthesis pathway to be expressed brain. A targeted metabolomic analysis acids measured from samples 111 individuals supports these results. Our metabolic network that taurine transport, synthesis, metabolism differ AD cognitively normal...
Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large differences. We systematically investigated group-specific alterations by conducting stratified association analyses of 139 serum metabolites 1,517 individuals from the Neuroimaging Initiative with biomarkers. observed substantial differences effects 15 partially overlapping status groups. Several...
Metabolites, the biochemical products of cellular process, can be used to measure alterations in pathways related pathogenesis Alzheimer's disease (AD). However, relationships between systemic abnormalities metabolism and AD are poorly understood. In this study, we aim identify AD-specific metabolomic changes their potential upstream genetic transcriptional regulators through an integrative systems biology framework for analyzing genetic, transcriptomic, metabolomic, proteomic data AD....
Importance Metabolomics reflect the net effect of genetic and environmental influences thus provide a comprehensive approach to evaluating pathogenesis complex diseases, such as depression. Objective To identify metabolic signatures major depressive disorder (MDD), elucidate direction associations using mendelian randomization, evaluate interplay human gut microbiome metabolome in development MDD. Design, Setting Participants This cohort study used data from participants UK Biobank (n = 500...