A5100745368- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Health and Wellbeing Research
- Genetic Associations and Epidemiology
- Environmental Toxicology and Ecotoxicology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- Advanced Battery Technologies Research
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Advanced Battery Materials and Technologies
- Genomics and Phylogenetic Studies
- Advancements in Battery Materials
- Toxic Organic Pollutants Impact
- Single-cell and spatial transcriptomics
- Diabetes Management and Education
- Diabetes Management and Research
- Genomic variations and chromosomal abnormalities
- Neuroinflammation and Neurodegeneration Mechanisms
- ATP Synthase and ATPases Research
- Plant Micronutrient Interactions and Effects
- Mitochondrial Function and Pathology
- Pharmaceutical and Antibiotic Environmental Impacts
- Genomics and Rare Diseases
- Mindfulness and Compassion Interventions
Nanjing Drum Tower Hospital
2025
Chinese Academy of Sciences
2010-2024
University of Macau
2023-2024
Anhui Normal University
2013-2024
University of Chinese Academy of Sciences
2010-2024
Wuhan Puai Hospital
2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Huashan Hospital
2023-2024
State Key Laboratory of Medical Neurobiology
2023-2024
Abstract Alzheimer’s disease (AD) affects half the US population over age of 85 and is universally fatal following an average course 10 years progressive cognitive disability. Genetic genome-wide association studies (GWAS) have identified about 33 risk factor genes for common, late-onset AD (LOAD), but these loci fail to account majority affected cases can neither provide clinically meaningful prediction development nor offer actionable mechanisms. This cohort study generated large-scale...
Three major molecular subtypes of Alzheimer’s disease are identified, cross-validated, and characterized across 1543 individuals.
Abstract An integrative multi-omics database is needed urgently, because focusing only on analysis of one-dimensional data falls far short providing an understanding cancer. Previously, we presented DriverDB, a cancer driver gene that applies published bioinformatics algorithms to identify genes/mutations. The updated DriverDBv3 (http://ngs.ym.edu.tw/driverdb) designed interpret omics’ sophisticated information with concise visualization. To offer diverse insights into molecular...
Metabolites, the biochemical products of cellular process, can be used to measure alterations in pathways related pathogenesis Alzheimer's disease (AD). However, relationships between systemic abnormalities metabolism and AD are poorly understood. In this study, we aim identify AD-specific metabolomic changes their potential upstream genetic transcriptional regulators through an integrative systems biology framework for analyzing genetic, transcriptomic, metabolomic, proteomic data AD....
Abstract Genetic recombination is a very important evolutionary mechanism that mixes parental haplotypes and produces new raw material for organismal evolution. As result, information on rates critical biological research. In this paper, we introduce extremely fast open-source software package (FastEPRR) uses machine learning to estimate rate ρ (=4Ner) from intraspecific DNA polymorphism data. When ρ>10 the number of sampled diploid individuals large enough (≥50), variance ρFastEPRR...
Femur fracture is a type of with high disability and mortality. There no comprehensive analysis prediction the global distribution femur fractures, so we conducted this study. Age-standardized incidence rate (ASIR), age-standardized prevalence (ASPR), years living (YLDs) fractures (excluding femoral neck) were downloaded from Global burden disease database. Trend was performed, 6 time-series machine learning algorithms applied to predict ASIR, ASPR, YLDs. ASPR for had been increasing in most...
Recent studies revealed the association of abnormal methylomic changes with Alzheimer's disease (AD) but there is a lack systematic study impact alterations over molecular networks underlying AD.
Significance The current rate of species extinction is ∼1,000 times the background and attributable to human impact, ecological demographic fluctuations, inbreeding due small population sizes. initiation date rapid decline (RPD) can provide important clues about driving forces in threatened species, but they are generally unknown. We analyzed genetic diversity data 2,764 vertebrate species. Our genetics modeling suggests that many RPD on average began late 19th century, mean size vertebrates...
The geographic origin and migration of the brown rat (Rattus norvegicus) remain subjects considerable debate. In this study, we sequenced whole genomes 110 wild rats with a diverse world-wide representation. We reveal that migrated out southern East Asia, rather than northern Asia as formerly suggested, into Middle then to Europe Africa, thousands years ago. Comparison from different geographical populations reveals many genes involved in immune system experienced positive selection rat.
Abstract The extreme fast charging performance of lithium metal batteries (LMBs) with a long life is an important focus in the development next-generation battery technologies. friable solid electrolyte interphase and dendritic growth are major problems. We report formation inorganic nanocrystal-dominant produced by pre-immersing Li molten bis(fluorosulfonyl)imide that suppresses overgrowth usual interphase. Its high surface modulus combined + diffusivity enables reversible dendrite-proof...
Abstract The extreme fast charging performance of lithium metal batteries (LMBs) with a long life is an important focus in the development next‐generation battery technologies. friable solid electrolyte interphase and dendritic growth are major problems. formation inorganic nanocrystal‐dominant produced by preimmersing Li molten bis(fluorosulfonyl)imide that suppresses overgrowth usual reported. Its high surface modulus combined + diffusivity enables reversible dendrite‐proof deposition...
Caerulomycins (CAEs) and collismycins (COLs), which mainly differ in sulfur decoration, are two groups of structurally similar natural products containing a 2,2'-bipyridine (2,2'-BP) core, derivatives have been widely used chemistry. The biosynthetic pathways CAEs COLs remain elusive. In this work, cloning the CAE gene cluster allowed us to mine highly conserved encoding COL biosynthesis Streptomyces strain that was previously unknown as 2,2'-BP producer. vitro vivo investigations into...
Glycerol-3-phosphate dehydrogenase 1 (GPD1) gene defect can cause hypertriglyceridemia (HTG), which usually occurs in infants. The has rarely been reported adult HTG patients. In the present study, we described clinical and functional analyses of a novel GPD1 missense variant Chinese patient with recurrent hypertriglyceridemia‑related acute pancreatitis (HTG-AP), consuming high-fat diet smoking heavily. Exome sequencing was used to analyze DNA patient's blood sample. It found that there new...
The cell wall is the primary cellular structure that encounters and perceives Al³⁺, acting as first line of defense against aluminum (Al) toxicity. Xyloglucan endotransglucosylase/hydrolase (XTH) plays a pivotal role in mediating remodeling, critical mechanism for Al toxicity tolerance. In our previous studies, candidate gene BnaXTH22 was identified through GWAS RNA-seq analyses. Under stress, overexpression lines (OEs) exhibited significant increase relative elongation taproots...
Abstract Background Variation of gene number among species indicates that there is a general process new origination. One the major mechanism providing raw materials for origin genes duplication. Retroposition, as special type duplication- RNA-based duplication, has been found to play an important role in evolution mammals and plants, but little known about teleostei genome. Results Here we screened zebrafish genome identification retrocopies chimerical retrogenes investigated their...
The traditionally accepted relationships among basal jawed vertebrates have been challenged by some molecular phylogenetic analyses based on mitochondrial sequences. Those studies split extant gnathostomes into two monophyletic groups: tetrapods and piscine branch, including Chondrichthyes, Actinopterygii sarcopterygian fishes. Lungfish bichir are found in a position the branch. Based transcriptomes of an armored (Polypterus delhezi) African lungfish (Protopterus sp.) we generated, expressed...