A5060584172- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Nerve injury and regeneration
- Nuclear Receptors and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Phytochemistry and Biological Activities
- GDF15 and Related Biomarkers
- Cancer-related Molecular Pathways
- Neuroscience of respiration and sleep
- Signaling Pathways in Disease
- Pharmacological Effects of Natural Compounds
- Endoplasmic Reticulum Stress and Disease
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
Nathan Kline Institute for Psychiatric Research
2023
New York University
2023
Rockefeller University
2014-2021
Rappaport Family Institute for Research in the Medical Sciences
2005-2009
Family Research Institute
2006-2008
Foundation Center
2005-2008
Technion – Israel Institute of Technology
2002-2007
Abstract We have recently shown that the anti‐Parkinson‐propargyl‐containing monoamine oxidase B (MAO‐B) inhibitor drug, rasagiline [ N ‐propargyl‐(1R)‐aminoindan], and its cholinesterase derivatives TV3326 TV3279, regulate amyloid precursor protein (APP) processing by a kinase C (PKC)‐dependent mechanism in SH‐SY5Y neuroblastoma PC12 cells. In present study, we investigated effect of on regulation PKC‐dependent APP under vivo conditions. Administration (0.1 mg/kg) to male C57/BL mice for 14...
Little is known about the molecular similarities and differences between neurons in ventral (vSt) dorsal striatum (dSt) their physiological implications. In vSt, serotonin [5-Hydroxytryptamine (5-HT)] modulates mood control pleasure response, whereas dSt, 5-HT regulates motor behavior. Here we show that, mice, depolarizes cholinergic interneurons (ChIs) of dSt hyperpolarizing ChIs from vSt by acting on different receptor isoforms. 5-HT1A (a postsynaptic receptor) 5-HT1B presynaptic are...
The behavioral response to antidepressants is closely associated with physiological changes in the function of neurons hippocampal dentate gyrus (DG). Parvalbumin interneurons are a major class GABAergic neurons, essential for DG function, and involved pathophysiology several neuropsychiatric disorders. However, little known about role(s) these depressive disorder or mediating delayed antidepressants. Here we show, mice, that parvalbumin express functionally silent serotonin 5A receptors,...
BackgroundParvalbumin (PV)-expressing interneurons are important for cognitive and emotional behaviors. These neurons express high levels of p11, a protein associated with depression action antidepressants.MethodsWe characterized the behavioral response to subthreshold stress in mice conditional deletion p11 PV cells. Using chemogenetics, viral-mediated gene delivery, specific ion channel agonist, we studied role dentate gyrus cells regulating anxiety-like behavior resilience stress. We used...
Abstract (R)‐[( N ‐propargyl‐(3 R ) aminoindan‐5‐yl) ethyl methyl carbamate] (TV3326) is a novel cholinesterase and brain‐selective monoamine oxidase (MAO)‐A/‐B inhibitor. It was developed for the treatment of dementia co‐morbid with extra pyramidal disorders (parkinsonism), depression. On chronic in mice it attenuated striatal dopamine depletion induced by MPTP prevented reduction tyrosine hydroxylase activity, like selective B non‐selective MAO inhibitors. TV3326 preferentially inhibits...
The present study aimed to acquire more information on aging-related alterations, using proteomic and genomic analyses of hippocampus from young (8 months) old (27 rats. In the rats, analysis identified changes in proteins related iron-mediated oxidative stress (OS) pathway, including reduction antioxidant enzymes (e.g., peroxiredoxin, cytochrome c oxidase) induction ferritin. Furthermore, neurofilament light peptide, associated with neurodegenerative processes, was enhanced binding/...
Significance The function of the basal ganglia relies on striatal spiny projecting neurons (SPNs). Axon collaterals these GABAergic form connections with other SPNs as a means feedback inhibition circuit. mechanisms that regulate neurotransmission at local synapses remain poorly understood. In this paper, SPN is found to be regulated by gaseous neurotransmitter nitric oxide, which activates signal-transduction cascade transcriptionally regulates vesicular GABA transporter specifically axon...
A recent study showed that p11 expressed in cholinergic interneurons (CINs) of the nucleus accumbens (NAc) is a key regulator depression-like behaviors. Dopaminergic neurons projecting to NAc are responsible for reward-related behaviors, and their function impaired depression. The present investigated role CINs dopamine responses rewarding stimuli. extracellular acetylcholine (ACh) levels were determined freely moving male mice using <i>in vivo</i> microdialysis. Rewarding stimuli (cocaine,...
The novel drugs, ladostigil (TV3326) and TV3279, are R S isomers, respectively, derived from a combination of the carbamate cholinesterase (ChE) inhibitor, rivastigmine, pharmacophore monoamine oxidase (MAO) B rasagiline. They were developed for treatment comorbidity dementia with Parkinsonism. In present study, we determined effects these drugs on both aminergic neurotransmitter levels motor behavioral activity in naïve L-dopa- or L-tryptophan-induced rats. Chronic rats (52 mg kg(-1) 21...
Abstract Among the hallmarks of major depressive disorders (MDD) are molecular, functional, and morphological impairments in hippocampus. Recent studies suggested a key role for hippocampal GABAergic interneurons both depression response to its treatments. These highly express chromatin-remodeler SMARCA3 which mediates chronic antidepressants an unknown mechanism. Using cell-type-specific molecular physiological approaches, we report that glutamatergic signaling by repressing expression...
Abstract The delayed behavioral response to chronic antidepressants depends on dynamic changes in the hippocampus. It was suggested that antidepressant protein p11 and chromatin remodeling factor SMARCA3 mediate this by inducing transcriptional hippocampal neurons. However, what target genes are regulated p11/SMARCA3 complex antidepressants, cell type mediates these molecular remain unknown. Here we report represses Neurensin-2 transcription parvalbumin-expressing interneurons after...