A5055242011- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Photoreceptor and optogenetics research
- Cholinesterase and Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
- Grief, Bereavement, and Mental Health
- Organ Donation and Transplantation
Kurume University
2016-2018
Tokyo Women's Medical University
2016
Tsurumi University
2016
Mitsubishi Group (Japan)
1987
Depression is a leading cause of disability. Current pharmacological treatment depression insufficient, and development improved treatments especially for treatment-resistant desired. Understanding the neurobiology antidepressant actions may lead to therapeutic approaches. Here, we demonstrate that dopamine D1 receptors in dentate gyrus act as pivotal mediator mice. Chronic administration selective serotonin reuptake inhibitor (SSRI), fluoxetine, increases receptor expression mature granule...
A recent study showed that p11 expressed in cholinergic interneurons (CINs) of the nucleus accumbens (NAc) is a key regulator depression-like behaviors. Dopaminergic neurons projecting to NAc are responsible for reward-related behaviors, and their function impaired depression. The present investigated role CINs dopamine responses rewarding stimuli. extracellular acetylcholine (ACh) levels were determined freely moving male mice using <i>in vivo</i> microdialysis. Rewarding stimuli (cocaine,...
Cortical dopamine and noradrenaline are involved in the stress response. Citalopram, a selective serotonin reuptake inhibitor, has direct indirect effects on serotonergic system. Furthermore, long-term treatment with citalopram affects systems, which could contribute to therapeutic action of antidepressants. The responses systems rat prefrontal cortex acute handling were evaluated using vivo microdialysis. Acute increased levels cortex. suppressed by local infusion 5-HT1A receptor agonist,...
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