A5007768734- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Advanced biosensing and bioanalysis techniques
- Brain Tumor Detection and Classification
- Metabolomics and Mass Spectrometry Studies
- Antimicrobial Peptides and Activities
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Polydiacetylene-based materials and applications
- Neurobiology of Language and Bilingualism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Algal biology and biofuel production
- Intracerebral and Subarachnoid Hemorrhage Research
- Vasculitis and related conditions
- Cerebrospinal fluid and hydrocephalus
- Amyloidosis: Diagnosis, Treatment, Outcomes
Sungkyunkwan University
2013-2025
Samsung Medical Center
2013-2025
Convergence
2023-2025
Indiana University School of Medicine
2020-2024
Indiana University – Purdue University Indianapolis
2020-2024
Cognitive Neuroimaging Lab
2023
Samsung (United Kingdom)
2023
Indiana University
2020-2023
University School
2020-2023
Samsung (South Korea)
2023
In Alzheimer's continuum (a comprehensive of preclinical disease [AD], mild cognitive impairment [MCI] due to AD, and AD dementia), dysfunctions are often related cortical atrophy in specific brain regions. The purpose this study was investigate the association between anatomical pattern neuropsychological deficits.A total 249 participants with (125 dementia, 103 MCI 21 AD) who were confirmed be positive for amyloid deposits collected from memory disorder clinic department neurology at...
Alzheimer's disease is the most common cause of dementia, and currently, there no disease-modifying treatment. Favorable functional outcomes reduction amyloid levels were observed following transplantation mesenchymal stem cells (MSCs) in animal studies.We conducted a phase I clinical trial nine patients with mild-to-moderate dementia to evaluate safety dose-limiting toxicity three repeated intracerebroventricular injections human umbilical cord blood-derived MSCs (hUCB-MSCs).We recruited...
In a clinical setting, an individual subject classification model rather than group analysis would be more informative. Specifically, the subtlety of cortical atrophy in some frontotemporal dementia (FTD) patients and overlapping patterns among three FTD syndromes including behavioral variant (bvFTD), non-fluent/agrammatic primary progressive aphasia (nfvPPA), semantic PPA (svPPA) give rise to need for models at level. this study, we aimed classify each into one diagnostic categories...
Abstract Background The retina and the brain share anatomic, embryologic, physiologic characteristics. Therefore, retinal imaging in patients with disorders has been of significant interest. Using optical coherence tomography angiography (OCTA), a novel quantitative method measuring vasculature, we aimed to evaluate radial peripapillary capillary (RPC) network density nerve fiber layer (RNFL) thickness cognitively impaired determine their association markers. Methods In this prospective...
Purpose of the Report: This study investigated prevalence and clinical characteristics suspected non-Alzheimer disease pathophysiology (SNAP) across varying cognitive statuses cerebral small vessel (CSVD) burden. Patients Methods: We included 1992 participants with status categorized as cognitively unimpaired, mild impairment, or dementia. β-amyloid (Aβ, A) positivity was assessed by Aβ PET, neurodegeneration (N) determined through hippocampal volume. Participants were further divided...
Abstract Among mild cognitive impairment (MCI) patients, those with memory (amnestic MCI, aMCI) are at a high risk of dementia. However, the precise domain, beside memory, that predicts dementia conversion is unclear. Therefore, we investigated domain in longitudinal aMCI cohort. We collected data 482 patients who underwent neuropsychological tests and magnetic resonance imaging baseline were followed for least 1 year. The categorized according to number (1–4) type impaired domains (memory,...
Abstract Background Alzheimer’s disease (AD) is neuropathologically characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The main protein components of these hallmarks include Aβ40, Aβ42, tau, phosphor-tau, APOE. We hypothesize that genetic variants influence the levels solubility AD-related proteins in brain; identifying may provide key insights into pathogenesis. Methods Genome-wide genotypes were collected from 441 AD cases, imputed to haplotype reference consortium...
Abstract Previous studies on Alzheimer’s disease-type cognitive impairment (ADCI) and subcortical vascular (SVCI) has rarely explored spatiotemporal heterogeneity. This study aims to identify distinct cortical atrophy patterns in ADCI SVCI. 1,338 participants (713 ADCI, 208 SVCI, 417 cognitively unimpaired elders) underwent brain magnetic resonance imaging (MRI), amyloid positron emission tomography, neuropsychological tests. Using MRI, this measures thickness five regions (medial temporal,...
Dementia, particularly Alzheimer's disease, is a significant global health concern, with early diagnosis and treatment development being critical goals. While numerous cohorts have advanced dementia research, there lack of comprehensive data on ethnic differences, for the Korean population. The Korea-Registries to Overcome Dementia Accelerate Research (K-ROAD) aims establish large-scale, hospital-based cohort address this gap, focus understanding disease progression, developing diagnostics,...
The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce variance in Aβ CL unit between 18F-florbetaben (FBB) 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 participants using direct comparison of FBB-FMM (dcCL) with four regions: cerebellar gray (CG), whole cerebellum (WC), WC brainstem (WC + B), pons. FBB FMM dcCL units were highly correlated (R2 =...
Abstract Predicting amyloid positivity in patients with mild cognitive impairment (MCI) is crucial. In the present study, we predicted structural MRI using a radiomics approach. From MR images (including T1, T2 FLAIR, and DTI sequences) of 440 MCI patients, extracted features composed histogram texture features. These were used alone or combination baseline non-imaging predictors such as age, sex, ApoE genotype to predict positivity. We regularized regression method for feature selection...
Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with Aβ cerebral small vessel disease (CSVD) burdens are not fully understood Asians. Herein, we investigated between profile components CSVD a large, non-demented Korean cohort.We enrolled 1,175 participants (456 unimpaired cognition [CU] 719 mild cognitive impairment [MCI]) aged ≥ 45 years who underwent PET at Samsung Medical Center Korea. We performed...
We aimed to determine whether lobar cerebellar microbleeds or concomitant and deep microbleeds, in the presence of cerebral attribute underlying advanced amyloid angiopathy pathology hypertensive arteriopathy.We categorized 71 patients with suspected markers (regardless microbleeds) into 4 groups according microbleed distribution: L (strictly cerebral, n=33), L/LCbll strictly n=13), L/Cbll/D (lobar, cerebellar, n=17), L/D (lobar deep, n=8). additionally 2 dentate nucleus involvement: (n=16)...
Abstract We aimed to quantitatively and qualitatively assess whether there is a discrepancy in detecting amyloid beta (Aβ) positivity between 18F-florbetaben (FBB) 18F-flutemetamol (FMM) positron emission tomography (PET). obtained paired FBB FMM PET images from 107 participants. Three experts visually quantified the Aβ deposition as positive or negative. Quantitative assessment was performed using global cortical standardized uptake value ratio (SUVR) with whole cerebellum reference region....
Abstract To characterize the course of Alzheimer’s disease (AD) over a longer time interval, we aimed to construct model for entire span using two separate cohorts ranging from preclinical AD dementia. We modelled progression 436 patients with continuum and investigated effects apolipoprotein E ε4 (APOE ε4) sex on progression. develop dementia, estimated Disease Assessment Scale-Cognitive Subscale 13 (ADAS-cog 13) scores. When calculated as median ADAS-cog scores each cohort, MCI due was 7.8...
Objectives Alzheimer’s disease (AD) is characterised by amyloid-beta accumulation (A), tau aggregation (T) and neurodegeneration (N). Vascular (V) burden has been found concomitantly with AD pathology synergistic effects on cognitive decline biomarkers. We determined whether trajectories of AT(N) categories differed according to vascular burden. Methods prospectively recruited 205 participants classified them into groups based the system using neuroimaging markers. Abnormal V markers were...
A comparative physical map of the AA genome (Oryza sativa) and BB (O. punctata) was constructed by aligning a O. punctata, deduced from 63,942 BAC end sequences (BESs) 34,224 fingerprints, onto sativa sequence. The level conservation each chromosome between two species determined calculating ratio BES alignments. alignment result suggests more divergence intergenic repeat regions in comparison to gene-rich regions. Further, this characteristic enabled localization heterochromatic euchromatic...
White matter hyperintensity (WMH) has been recognised as a surrogate marker of small vessel disease and is associated with cognitive impairment. We investigated the dynamic change in WMH patients severe at baseline, effects longitudinal volume on decline cortical thinning. Eighty-seven subcortical vascular mild impairment were prospectively recruited from single referral centre. All followed up annual neuropsychological tests 3T brain magnetic resonance imaging. The was quantified using an...