A5100666849- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Food Quality and Safety Studies
- ECG Monitoring and Analysis
- Nutrition, Health and Food Behavior
- Agriculture, Soil, Plant Science
- Health and Wellbeing Research
- Cardiac electrophysiology and arrhythmias
- Fermentation and Sensory Analysis
- Functional Brain Connectivity Studies
- Protein Hydrolysis and Bioactive Peptides
- Traumatic Brain Injury and Neurovascular Disturbances
- Insect Utilization and Effects
- Ultrasound and Hyperthermia Applications
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Non-Invasive Vital Sign Monitoring
- Genetic Associations and Epidemiology
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Frailty in Older Adults
- Blood Pressure and Hypertension Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Glaucoma and retinal disorders
Hallym University Dongtan Sacred Heart Hospital
2021-2025
Hallym University
2024-2025
Korea Aerospace University
2024
Klinik für Frauenheilkunde
2024
Ludwig-Maximilians-Universität München
2024
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2024
Weill Cornell Medicine
2024
Cornell University
1984-2024
Samsung Medical Center
2017-2023
Sungkyunkwan University
2017-2023
Abstract INTRODUCTION This study aimed to investigate the differential roles of various plasma biomarkers in a stepwise diagnostic strategy for Alzheimer's disease (AD). METHODS A total 2984 participants, including 666 cognitively unimpaired (CU), 2032 with clinical syndrome (ACS), and 286 non‐ACS individuals, were recruited. Plasma amyloid beta (Aβ) 42/40, four phosphorylated tau (p‐tau) epitopes, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) levels measured using...
In Alzheimer's continuum (a comprehensive of preclinical disease [AD], mild cognitive impairment [MCI] due to AD, and AD dementia), dysfunctions are often related cortical atrophy in specific brain regions. The purpose this study was investigate the association between anatomical pattern neuropsychological deficits.A total 249 participants with (125 dementia, 103 MCI 21 AD) who were confirmed be positive for amyloid deposits collected from memory disorder clinic department neurology at...
Importance Understanding the characteristics of discordance between plasma biomarkers and positron emission tomography (PET) results in Alzheimer disease (AD) is crucial for accurate interpretation findings. Objective To compare (1) medical comorbidities affecting biomarker concentrations, (2) imaging clinical features, (3) cognitive changes PET discordant concordant cases. Design, Setting, Participants This multicenter cohort study, conducted 2016 2023, included individuals with unimpaired...
Epidural spinal cord compression was produced in rats by injection of Walker 256 carcinoma cell suspension anterior to the T-12 or T-13 vertebral body. The tumor grows through intervertebral foramina compress and produce paraplegia 3 4 weeks. effect several treatments upon clinical signs assessed. Dexamethasone caused a significant but transient improvement neurological function. Radiation therapy likewise improved function, more effective when given high-dose protracted course than either...
Abstract Background The retina and the brain share anatomic, embryologic, physiologic characteristics. Therefore, retinal imaging in patients with disorders has been of significant interest. Using optical coherence tomography angiography (OCTA), a novel quantitative method measuring vasculature, we aimed to evaluate radial peripapillary capillary (RPC) network density nerve fiber layer (RNFL) thickness cognitively impaired determine their association markers. Methods In this prospective...
Background and objective Migraine is a common chronic neurological disease characterized by pulsating headaches, photophobia, phonophobia, nausea, vomiting. The prevalence of dementia in individuals aged over 65 years Korea more than 10%, Alzheimer’s (AD) accounts for most cases. Although these two diseases account large portion the medical burden Korea, few studies have examined relationship between diseases. Therefore, this study investigated incidence risk AD patients with migraines....
Abstract Predicting amyloid positivity in patients with mild cognitive impairment (MCI) is crucial. In the present study, we predicted structural MRI using a radiomics approach. From MR images (including T1, T2 FLAIR, and DTI sequences) of 440 MCI patients, extracted features composed histogram texture features. These were used alone or combination baseline non-imaging predictors such as age, sex, ApoE genotype to predict positivity. We regularized regression method for feature selection...
Efficient transport of solutes in the cerebrospinal fluid (CSF) plays a critical role their clearance from brain. Convective bulk flow CSF perivascular space (PVS) is considered one important mechanisms behind solute movement brain, before ultimate drainage to systemic lymphatic system. Acoustic pressure waves can impose radiation force on medium its path, inducing localized and directional fluidic flow, known as acoustic streaming. We transcranially applied low-intensity focused ultrasound...
Empathy comprises cognitive and emotional components. However, the impairments in empathy among individuals with mild impairment (MCI) dementia of Alzheimer's type (DAT) are not well understood, particularly context depression, which may exacerbate these deficits. This study aimed to evaluate effects neurodegeneration depression on empathetic abilities. The included 31 healthy elderly (HE) individuals, 30 patients amnestic multi-domain MCI (amMCI), DAT. was assessed using Korean-Multifaceted...
We aimed to determine whether lobar cerebellar microbleeds or concomitant and deep microbleeds, in the presence of cerebral attribute underlying advanced amyloid angiopathy pathology hypertensive arteriopathy.We categorized 71 patients with suspected markers (regardless microbleeds) into 4 groups according microbleed distribution: L (strictly cerebral, n=33), L/LCbll strictly n=13), L/Cbll/D (lobar, cerebellar, n=17), L/D (lobar deep, n=8). additionally 2 dentate nucleus involvement: (n=16)...
Abstract Background Although few studies have shown that risk factors for Alzheimer’s disease (AD) are associated with cognitive decline in AD, not much is known whether the impact of differs between early-onset AD (EOAD, symptom onset < 65 years age) versus late-onset (LOAD). Therefore, we evaluated on trajectories differ EOAD and LOAD. Methods We followed-up 193 476 LOAD patients without autosomal dominant mutation 32.3 ± 23.2 months. Mixed-effects model analyses were performed to...
Amyloid-beta (Aβ) plaques are key in Alzheimer's disease (AD), with Aβ positron emission tomography imaging enabling non-invasive quantification. To address regional deposition, we developed Centiloid scales (rdcCL) and commercialized them through the computed (CT)-based BeauBrain Amylo platform, eliminating need for three-dimensional T1 magnetic resonance (MRI). We aimed to establish robust cutoffs using platform explore prevalence of subgroups defined by global, regional, striatal across...
Discrimination of ventricular and supraventricular arrhythmias remains one the major challenges for appropriate implantable defibrillator (ICD) therapy delivery. The electrogram vector timing correlation (VTC) algorithm was developed such rhythm discrimination. VTC differentiates normally conducted beats from abnormally by comparing rate shock channel electrograms.Rate electrograms sinus induced were collected 93 patients during ICD placement. using data 50 prospectively tested in a software...
We measured physiological functionalities, including antihypertensive angiotensin I-converting enzyme inhibitory activity and immun-stimulating β-glucan content for sixty kinds of Makgeolli that is commercially available from the market. As a result, we selected R-12 commercial raw Makgeolli, with high immuno-stimulating β-glucan, R-14 exhibiting activity. Due to similarities in their overall physicochemical properties materials used fermentation, compared microbial flora order investigate...
Background and objectives: The differences between computed radiography-based teleoroentgenograms (CR-based teleoroentgenograms) an EOS® imaging system were evaluated by measuring lower extremity lengths alignments. Materials methods: leg length [L], femur [F], tibia [T], hip−knee−ankle (HKA) angle measured in 101 patients with disease a CR-based teleoroentgenogram radiography EOS®. additive of the femoral tibial segments (F + T) was determined adding two values. Then, among all five...
Background Cerebrospinal fluid (CSF) biomarkers are increasingly used in clinical practice for the diagnosis of Alzheimer's disease (AD). We aimed to 1) determine cutoff values CSF AD, 2) investigate their utility by estimating a concordance with amyloid positron emission tomography (PET), and 3) apply ATN (amyloid/tau/neurodegeneration) classification based on results. Methods performed analysis 51 normal controls (NC), 23 mild cognitive impairment (MCI) 65 AD dementia (ADD) patients at...
Abstract We developed machine learning (ML) algorithms to predict abnormal tau accumulation among patients with prodromal AD. recruited 64 AD using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Supervised ML approaches based on random forest (RF) and a gradient boosting (GBM) were used. The GBM resulted in an AUC of 0.61 (95% confidence interval [CI] 0.579–0.647) clinical data (age, sex, years education) higher 0.817 CI 0.804–0.830) neuropsychological data. highest was 0.86...
We evaluated how the impact of apolipoprotein E4 ( APOE4) differs according to age in Alzheimer’s disease (AD) patients. recruited 846 AD patients and 815 cognitively normal controls categorized into three groups with respect their (<65, 65–74, ≥75 years). risk APOE4 carriers compared cortical thickness cognitive function status each group. At point this study, young (<65 years) AD, noncarriers had most severe frontal perisylvian atrophy, while old (≥75 medial temporal atrophy. In...