A5022276770- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Nutritional Studies and Diet
- Neurological Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Health, Environment, Cognitive Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health in Aging
- Functional Brain Connectivity Studies
- Vascular anomalies and interventions
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- Congenital Heart Disease Studies
- Advanced Neuroimaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Acute Ischemic Stroke Management
- Neurological Complications and Syndromes
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 and COVID-19 Research
- Frailty in Older Adults
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Herpesvirus Infections and Treatments
- Neurobiology of Language and Bilingualism
Evidence Based Research (United States)
2025
International Vaccine Institute
2025
Memorial Healthcare System
2024
Samsung Medical Center
2019-2024
Sungkyunkwan University
2019-2024
Samsung (South Korea)
2023
Seoul National University Hospital
2023
In Alzheimer's continuum (a comprehensive of preclinical disease [AD], mild cognitive impairment [MCI] due to AD, and AD dementia), dysfunctions are often related cortical atrophy in specific brain regions. The purpose this study was investigate the association between anatomical pattern neuropsychological deficits.A total 249 participants with (125 dementia, 103 MCI 21 AD) who were confirmed be positive for amyloid deposits collected from memory disorder clinic department neurology at...
Importance Understanding the characteristics of discordance between plasma biomarkers and positron emission tomography (PET) results in Alzheimer disease (AD) is crucial for accurate interpretation findings. Objective To compare (1) medical comorbidities affecting biomarker concentrations, (2) imaging clinical features, (3) cognitive changes PET discordant concordant cases. Design, Setting, Participants This multicenter cohort study, conducted 2016 2023, included individuals with unimpaired...
Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with Aβ cerebral small vessel disease (CSVD) burdens are not fully understood Asians. Herein, we investigated between profile components CSVD a large, non-demented Korean cohort.We enrolled 1,175 participants (456 unimpaired cognition [CU] 719 mild cognitive impairment [MCI]) aged ≥ 45 years who underwent PET at Samsung Medical Center Korea. We performed...
Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored. To investigate the associations among PA; biomarkers, including β-amyloid 42/40 (Aβ42/40), phosphorylated-tau217 (ptau217), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL); cognition. This cross-sectional study included participants with without cognitive impairment recruited from multiple...
<title>Abstract</title> Adjuvants play a crucial role in enhancing vaccine-induced immune responses by shaping the magnitude and quality of humoral cellular immunity. However, mechanism through which different adjuvants modulate effector functions is not fully understood. Here, we developed an International Vaccine Institute liposome-based adjuvant (ILA) comprehensively compared profiles mice following administration SARS-CoV-2 spike (S) protein formulated with either ILA or aluminum...
Abstract Background Increasing evidence supports the association between body mass index (BMI), Alzheimer’s disease, and vascular markers. Recently, metabolically unhealthy conditions have been reported to affect expression of these We aimed investigate effects BMI status on markers in relation metabolic health status. Methods recruited 1,736 Asians without dementia (71.6 ± 8.0 years). Participants were categorized into underweight, normal weight, or obese groups based their BMI. Each group...
We aimed to investigate the association between glycemic variability (GV) and neuroimaging markers of white matter hyperintensities (WMH), beta-amyloid (Aβ), brain atrophy, cognitive impairment.
Studying structural brain aging is important to understand age-related pathologies, as well identify the early manifestations of Alzheimer's disease (AD) continuum. In this study, we investigated long-term trajectory physiological and pathological in a large number participants ranging from 50s over 80 years age.To explore distinct regions that distinguish using sophisticated measurements cortical thickness.A total 2,823 cognitively normal (CN) individuals 2,675 patients with AD continuum...
We aimed to investigate which factors affect plasma biomarker levels via amyloid beta (Aβ)-independent or Aβ-dependent effects and improve the predictive performance of these biomarkers for Aβ positivity on positron emission tomography (PET). A total 2935 participants underwent blood sampling measurements Aβ42/40 ratio, phosphorylated tau 217 (p-tau217; ALZpath), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) using single-molecule array PET. Laboratory findings were...
Amyloid-β (Aβ) evaluation in amnestic mild cognitive impairment (aMCI) patients is important for predicting conversion to Alzheimer's disease. However, Aβ through positron emission tomography (PET) limited due high cost and safety issues.We therefore aimed develop validate prediction models of positivity aMCI using optimal interpretable machine learning (ML) approaches utilizing multimodal markers.We recruited 529 from multiple centers who underwent PET. We trained ML algorithms a training...
The relationship of body mass index (BMI) changes and variability with amyloid-β (Aβ) deposition remained unclear, although there were growing evidence that BMI is associated the risk developing cognitive impairment or AD dementia. To determine whether affected Aβ positivity, we investigated association as assessed by PET in a non-demented population.We retrospectively recruited 1,035 participants ≥50 years age who underwent had at least three measurements memory clinic Samsung Medical...
To investigate the association between APOE genotype and β-amyloid (Aβ) burden, as measured by PET in patients with subcortical vascular cognitive impairment (SVCI) those Alzheimer disease-related (ADCI).This was a cross-sectional study of 310 SVCI 999 ADCI. evaluate effects or diagnostic group on Aβ positivity, we performed multivariate logistic regression analyses. Further distinctive underlying features latent subgroups were examined employing class cluster analysis approach.In comparison...
Background Non-alcoholic fatty liver disease (NAFLD) is known to be associated with a high risk of clinically diagnosed Alzheimer’s (AD). Additionally, the prevalence NAFLD and AD higher in elderly females than males. However, sex-specific association between amyloid-beta (Aβ) deposition remains unclear. Therefore, we investigated relationship Aβ large-sized cohort cognitively unimpaired (CU) individuals. Methods We enrolled 673 (410 [60.9%] 263 [39.1%] males) CU individuals aged ≥45 years...
Abstract Background Plasma biomarkers for Alzheimer’s disease (AD) have demonstrated their accuracy as diagnostic tools, suggesting impending integration into clinical practice. Medical comorbidities might not only affect AD pathological burdens but also cause variability of plasma by affecting transfer via blood brain barriers. In the present study, we aimed to determine which with (real effects) or without (biological variability) measured β‐amyloid (Aβ) uptakes on PET. Method We recruited...
Introduction Cerebral venous sinus thrombosis (CVST) is a rare but serious condition characterized by blood clot formation in the dural sinuses. It can manifest with symptoms ranging from mild headaches to severe complications such as cerebral herniation and death. CVST predominantly affects women aged 20‐40, comprising about 0.5‐1% of acute ischemic events. Although systemic anticoagulation first‐line treatment, 10‐20% cases require further interventions like mechanical thrombectomy and/or...
Introduction Cerebral arteriovenous malformations (AVM) are an abnormal tangle of blood vessels in the brain that connects arteries to veins directly. This can lead a variety symptoms, including headaches, hemorrhages, seizures, and progressive neurological deficits. Effective treatment requires multidisciplinary, individualized approach maximize positive outcomes. We present successful case 86‐year‐old male with complex cardiac history who developed acute‐onset weakness refractory focal...
Introduction Ebstein's anomaly (EA) is a rare congenital heart condition, accounting for less than 1% of defects. Though uncommon, individuals with EA have significantly increased risk stroke, through poorly understood mechanisms. We present case large vessel stroke in patient EA, coexisting patent foramen ovale (PFO), and conduction abnormalities, which ultimately required transplant. Materials/Methods N/A Case A 22‐year‐old male history Wolff‐Parkinson‐White Syndrome presented left middle...
Brain diseases complexity have necessitated advanced research platforms for better understanding, treatment, and prevention strategies. However, existing brain disease registries face limitations such as incomplete variable sets, lack of standardization, insufficient linkage to external databases, absence integrated comprehensive data collection, continuity. To address these challenges, the Korea National Institute Health initiated Research Infrastructure Data Gathering Exploration (BRIDGE),...
This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting cohorts from several variable levels.The following four were used develop this platform: 1) Clinical Research Center for Dementia South Korea (CREDOS), 2) Korean Brain Aging Study Early Diagnosis and Prediction Alzheimer's disease (K-BASE), 3) Environmental Pollution-induced Neurological Effects (EPINEF) study, 4) prospective registry in Platform (DPKR).A...
Abstract Background Cholesterol plays important roles in β‐amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with Aβ cerebral small vessel disease (CSVD) burdens are not fully understood Asians. Herein, we investigated between profile components CSVD a large, non‐demented Korean cohort. Method We enrolled 1,175 participants (456 unimpaired cognition [CU] 719 mild cognitive impairment [MCI]) aged ≥ 45 years who underwent PET at Samsung...