A5101953109- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Reconstructive Facial Surgery Techniques
- Animal Disease Management and Epidemiology
- Reconstructive Surgery and Microvascular Techniques
- Animal Virus Infections Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Air Quality and Health Impacts
- Advanced Glycation End Products research
- Mesenchymal stem cell research
- Sympathectomy and Hyperhidrosis Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nasal Surgery and Airway Studies
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Skin Diseases and Diabetes
- Prion Diseases and Protein Misfolding
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Full-Duplex Wireless Communications
- Veterinary Pharmacology and Anesthesia
- Dupuytren's Contracture and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
Samsung Medical Center
2016-2025
Sungkyunkwan University
2014-2025
Samsung (South Korea)
2025
Konkuk University
2012-2018
CTCBio (South Korea)
2016
Eulji University Hospital
2015
Eulji University
2014-2015
University of California, San Francisco
2015
University of California, Berkeley
2015
Kangbuk Samsung Hospital
2008-2013
Abstract INTRODUCTION This study aimed to investigate the differential roles of various plasma biomarkers in a stepwise diagnostic strategy for Alzheimer's disease (AD). METHODS A total 2984 participants, including 666 cognitively unimpaired (CU), 2032 with clinical syndrome (ACS), and 286 non‐ACS individuals, were recruited. Plasma amyloid beta (Aβ) 42/40, four phosphorylated tau (p‐tau) epitopes, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) levels measured using...
Abstract β‐secretase (BACE1) is instrumental in amyloid‐β (Aβ) production, with overexpression noted Alzheimer's disease (AD) neuropathology. The interaction of Aβ the receptor for advanced glycation endproducts (RAGE) facilitates cerebral uptake and exacerbates its neurotoxicity neuroinflammation, further augmenting BACE1 expression. Given limitations previous inhibition efforts, study explores reducing expression to mitigate AD pathology. research reveals that anticancer agent...
Background Plasma phosphorylated tau (p-tau) 217 test has emerged as a minimally invasive and accessible alternative to positron emission tomography imaging cerebrospinal fluid analysis for Alzheimer’s disease (AD) diagnostics. However, the diagnostic performance of p-tau217 across diverse cognitive demographic subgroups remains underexplored. This multicentre cross-sectional study aimed assess utility plasma using double cut-off approach in large, cohort, focusing on subgroup analyses based...
Center for Dementia of South Korea) StudyWith rapid population aging, the socioeconomic burden caused by dementia care is snowballing.Although a few community-based studies Alzheimer's disease (AD) have been performed in Korea, there has never nationwide hospital-based study thereof.We aimed to identify demographics and clinical characteristics mild-to-moderate AD patients from Clinical Research Korea (CREDOS) registry.A total 1,786 were consecutively included September 2005 June 2010.Each...
This study explored whether religiosity/spirituality has a protective role against negative caregiving outcomes, in large multicenter nationwide sample of caregivers patients with dementia South Korea. Additionally, this was the first to examine could affect outcomes according various religious affiliations caregivers.The conducted on 476 participated Clinical Research Center for Dementia Korea (CREDOS). We examined moderating effect each three dimensions (organizational activity, ORA;...
ABSTRACT Background: Subjective memory impairment (SMI) refers to conditions in which people complain of problems despite intact cognition. The primary purpose the present study was examine roles self-focused attention and depressive symptomatology subjective complaints. Methods: One hundred eight patients who visited a disorder clinic with complaints decline, but were found on subsequent neuropsychological assessment have normal cognitive function, recruited participate study. severity...
Background and purpose: Reports describing functional neuroimaging techniques, such as positron emission tomography (PET) single‐photon computed (SPECT), in sporadic Creutzfeldt–Jakob disease (sCJD) have consistently suggested that these tools are sensitive for the identification of areas hypoperfusion or hypometabolism, even early stages sCJD. However, there few reports on use [18F]fluoro‐2‐deoxy‐D‐glucose (FDG) PET sCJD, most them single case reports. Only two small cohort studies based...
Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored. To investigate the associations among PA; biomarkers, including β-amyloid 42/40 (Aβ42/40), phosphorylated-tau217 (ptau217), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL); cognition. This cross-sectional study included participants with without cognitive impairment recruited from multiple...
Importance As amyloid-targeted therapies have become commercially available, the monitoring of cerebral amyloid angiopathy (CAA), which is an important risk factor for amyloid-related imaging abnormalities, has received increasing attention. However, comprehensive evidence on association between Alzheimer disease (AD) plasma biomarkers and various CAA markers still lacking. Objective To examine with downstream AD in relation to amyloid-β (Aβ) uptake positron emission tomography (PET) whether...
Mesenchymal stem cells (MSCs) possess the potential for differentiation into multilineages. MSCs have been reported to play a role as precursors tumor stroma in providing favorable environment progression. Hyperthermia destroys cancer by raising temperature of tumor-loaded tissue 40 degrees C 43 and causes indirect sensitizing effects when combined with chemo- and/or radiotherapy. However, how hyperthermia affects tumor-supportive is unknown. Here, authors investigated hyperthermia-treated...
National dementia plans were applied in support centers established Seoul, Korea between 2007 and 2009. However, the annual incidence rates of Seoul have not been reported. We investigated this characteristics incident cases from 2003 to 2018. The customized research database Korean Health Insurance Services was used. crude age-standardized patients their analyzed. This study analyzed 108,596 aged ≥60 years. rate increased 2011, including a rapid increment 2011. From 2011 2018,...
Progressive multifocal leukoencephalopathy (PML) is a demyelinating central nervous system disease caused by JC virus (JCV) reactivation in immunocompromised patients. The course of PML often progressive, fatal and at present, there are few reports on successful treatment outcomes.A 45-year-old man with systemic sarcoidosis presented rapidly progressive dementia right hemiparesis. patient was diagnosed as confirmed via brain biopsy JCV PCR. With combination cidofovir mirtazapine, significant...
Soie Chung, M.D., Jun Sik Kim, M.T., Sang Won Seo, Eun Kyung Ra, Sei-Ick Joo, So Yeon Sung Sup Park, and Eui-Chong M.D.. Korean J Lab Med 2011;31:122-6. https://doi.org/10.3343/kjlm.2011.31.2.122
The advantages of the peroneal perforator flap include a short harvesting time, thinness, and pliability. Due to presence pedicle small vessel diameter, without sacrifice, this is commonly used for distal limb reconstruction, but rarely knee proximal middle lower leg reconstruction. We describe our experience with application versatile free reconstruction through supermicrosurgery.Between October 2010 August 2014, 22 patients small-to-medium-sized defects on their underwent surgery using...
Studies investigating the impact of white matter hyperintensities (WMHs) on response acetylcholinesterase inhibitors in patients with Alzheimer's disease (AD) have presented inconsistent results. We aimed to compare effects rivastigmine patch between AD minimal WMHs and those moderate WMHs.Three hundred mild were enrolled this multicenter prospective open-label study divided into two groups. Group 1 comprised group 2 WMHs. The treated a for 24 weeks. Efficacy measures obtained at baseline...
Abstract To evaluate the association between coronary artery calcium (CAC) and cortical thickness in a large sample of cognitively normal individuals, with special emphasis determining if has regional brain specificity it is mediated by white matter hyperintensities (WMH). A total 512 participants were included this study. CAC scores assessed multi-detector computed tomography. Cortical was measured using surface-based method. Linear mixed models used to assess thickness. In fully adjusted...