A5101872795- Advanced Glycation End Products research
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- NF-κB Signaling Pathways
- Inflammatory Bowel Disease
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
Deargen (South Korea)
2022-2025
Ministry of Food and Drug Safety
2018
Dankook University
2017-2018
Abstract β‐secretase (BACE1) is instrumental in amyloid‐β (Aβ) production, with overexpression noted Alzheimer's disease (AD) neuropathology. The interaction of Aβ the receptor for advanced glycation endproducts (RAGE) facilitates cerebral uptake and exacerbates its neurotoxicity neuroinflammation, further augmenting BACE1 expression. Given limitations previous inhibition efforts, study explores reducing expression to mitigate AD pathology. research reveals that anticancer agent...
Cancer-associated fibroblasts (CAFs) reside within the tumor microenvironment, facilitating cancer progression and metastasis via direct indirect interactions with cells other stromal cell types. CAFs are composed of heterogeneous subpopulations activated fibroblasts, including myofibroblastic, inflammatory, immunosuppressive CAFs. In this study, we sought to identify isolated from human lung adenocarcinomas describe their transcriptomic functional characteristics through single-cell RNA...
The challenges when developing a good de novo transcriptome assembler include how to deal with read errors and sequence repeats. Almost all assemblers utilize Bruijn graph, which complexity grows linearly data size while suffering from Although one can correct the by inspecting topological structure of this is not an easy task there are too many branches. Two research directions improve either graph reliability or path search precision, in study, we focused on former.We present TraRECo,...
In this study, dextran sulfate sodium (DSS)-induced in vivo model and LPS-stimulated vitro were used to confirm whether ethanol extract of Cnidii Rhizoma (EtCR) could ameliorate UC. EtCR improved symptoms UC, including body weight loss, colon length shortening, disease activity index (DAI), mucosal damage. addition, decreased inflammatory mediators, cyclooxygenase-2 (COX-2) inducible nitric oxide synthase (iNOS), tissue. To further the UC improving mechanism, RAW 264.7 cells HT29 human...
Abstract Background Challenges in developing a good de novo transcriptome assembler include how to deal with read errors and sequence repeats. Almost all assemblers utilize Bruijn graph, which has complexity linearly growing data size while suffers from repeat. Although one can correct by inspecting topological structure of the it is an uneasy task when there are too many branches. There two research directions: improving either graph reliability or path search precision. We focused on...
Abstract Background: Cancer-associated fibroblasts (CAFs) reside within the tumor microenvironment, facilitating cancer progression and metastasis via direct indirect interactions with cells as well other stromal cell types. CAFs are comprised of heterogeneous subpopulations activated fibroblasts, including myofibroblastic, inflammatory, or immunosuppressive CAFs. In this study, we sought to identify isolated from human lung adenocarcinomas describe their transcriptomic functional...