A5031083361- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Optical Coherence Tomography Applications
- Retinal Diseases and Treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Retinal Development and Disorders
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Corneal surgery and disorders
- Dementia and Cognitive Impairment Research
- Digital Imaging for Blood Diseases
- Machine Learning in Healthcare
- Cell Image Analysis Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Advanced Neuroimaging Techniques and Applications
- Ophthalmology and Eye Disorders
- Circular RNAs in diseases
- Advanced MRI Techniques and Applications
- Fibroblast Growth Factor Research
- AI in cancer detection
- Proteoglycans and glycosaminoglycans research
University of Nottingham
2020-2025
Ewha Womans University
2019-2025
Pusan National University
2022-2025
Simon Fraser University
2015-2024
Kyungpook National University
2024
Institute for Basic Science
2024
Seoul Medical Center
2022-2023
Gachon University
2022-2023
University of British Columbia
2017-2022
Institute of Molecular Biotechnology
2022
Accurate segmentation of the retinal microvasculature is a critical step in quantitative analysis circulation, which can be an important marker evaluating severity diseases. As manual remains gold standard for optical coherence tomography angiography (OCT-A) images, we present method automating OCT-A images using deep neural networks (DNNs). Eighty foveal region 12 eyes from 6 healthy volunteers were acquired prototype system and subsequently manually segmented. The automated blood vessels...
Three miR-34 family members (miR-34a, miR-34b, and miR-34c) are clustered on two different chromosomal loci, Mir34a Mir34b/c. These miRNAs have identical seed sequences, which predicted to target the same set of genes. However, miR-34a miR-34c sets negatively correlated genes in lung adenocarcinoma data from The Cancer Genome Atlas. Therefore, we hypothesized that individual members, tumor suppressive miRNAs, would varying effects tumorigenesis. To show this, overexpressed each cluster...
The microRNA‐200 (miR‐200) family plays a major role in specifying epithelial phenotype by preventing expression of the transcription repressors ZEB1 and ZEB2, which are well‐known regulators epithelial‐to‐mesenchymal transition (EMT) tumors including oral squamous cell carcinoma (OSCC). Here, we elucidated whether miR‐200 members control RNA‐binding protein quaking (QKI), newly identified tumor suppressor that is regulated during EMT. We predicted miR‐200a miR‐200b could recognize QKI...
Alzheimer's disease (AD) is the most prevalent form of dementia, accounting for 60-70% all dementias. AD often under-diagnosed and recognized only at a later, more advanced stage, this delay in diagnosis has been suggested as contributing factor numerous unsuccessful treatment trials. Although there no known cure AD, early important management care. A hallmark deposition amyloid-β (Aβ)-containing senile neuritic plaques neurofibrillary tangles composed hyperphosporylated tau brain. However,...
Abstract Amyloid beta (Aβ) deposits in the retina of Alzheimer’s disease (AD) eye may provide a useful diagnostic biomarker for AD. This study focused on relationship Aβ with macroglia and microglia, as these glial cells are hypothesized to play important roles homeostasis clearance AD retina. Significantly higher load was found compared controls, specifically mid-peripheral region. showed significantly less immunoreactivity against fibrillary acidic protein (GFAP) glutamine synthetase (GS)...
The interplay between apoptotic cancer cells and the tumor microenvironment modulates progression metastasis. Cancer-associated fibroblasts (CAFs) play a crucial role in promoting these events through paracrine communication. Here, we demonstrate that conditioned medium (CM) from lung CAFs exposed to suppresses TGF-β1-induced migration invasion of CAFs. Direct exposure 344SQ (ApoSQ) inhibited CAF expression activation markers. Enhanced secretion Wnt-induced signaling protein 1 (WISP-1) by...
Adult stem cells constantly react to local changes ensure tissue homeostasis. In the main body of stomach, chief produce digestive enzymes; however, upon injury, they undergo rapid proliferation for prompt regeneration. Here, we identified p57Kip2 (p57) as a molecular switch reserve cell state in mice. During homeostasis, p57 is expressed but rapidly diminishes after followed by robust proliferation. Both single-cell RNA sequencing and dox-induced lineage tracing confirmed sequential loss...
The present study investigated the effect of topical application Epidermidibacterium Keratini (EPI-7) ferment filtrate, which is a postbiotic product novel actinobacteria, on skin aging, by performing prospective randomized split-face clinical Asian woman participants. investigators measured biophysical parameters, including barrier function, elasticity, and dermal density, revealed that EPI-7 filtrate-including test resulted in significantly higher improvements density compared to placebo...
We compared the reproducibility and mutual agreement of subfoveal choroidal thickness measurements by expert raters an automated algorithm in enhanced depth imaging optical coherence tomography (EDI-OCT) images eyes with nonneovascular age-related macular degeneration (AMD).We recruited 44 patients AMD EDI-OCT were acquired. Subfoveal was measured manually two automatically a graph-cut-based algorithm. Drusen area using software (version 6) Cirrus SD-OCT. The manual reproducibility,...
Abstract Excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as Alzheimer’s, multiple sclerosis, and Parkinson's disease. Within eye, excitotoxicity is thought to play a critical role retinal ganglion cell death glaucoma, diabetic retinopathy, ischemia, optic nerve injury, yet how excitotoxic injury impacts different layers not well understood. Here, we investigated longitudinal effects N-methyl-D-aspartate...
This report describes a novel, non-invasive and label-free optical imaging technique, speckle variance coherence tomography (svOCT), for visualising blood flow within human retinal capillary networks. system uses custom-built swept source OCT operating at line rate of 100 kHz. Real-time processing visualisation is implemented on consumer grade graphics unit. To investigate the quality microvascular detail acquired with this device we compared images networks svOCT fluorescein angiography. We...
Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) plaques in the brain detectable highly invasive vivo imaging or post-mortem tissues. A non-invasive and inexpensive screening method needed for early diagnosis of asymptomatic AD patients. The shared developmental origin similarities with make retina a suitable surrogate tissue to assess Aβ load AD. Using curcumin, FluoroProbe that binds Aβ, we labeled measured retinal fluorescence compared immunohistochemical measurements...
To investigate morphological characteristics of optic nerve head and peripapillary region with myopia glaucoma.Ten normal 17 glaucomatous myopic participants were imaged a custom 1060-nm swept-source optical coherence tomography system. The three-dimensional images processed segmented for inner limiting membrane (ILM), posterior border retinal fiber layer (RNFL), Bruch's (BM), choroid. Seven shape parameters measured: (NFL) thickness; opening (BMO) area, eccentricity, planarity; BMO BM...
Background: The increasing availability of databases containing both magnetic resonance imaging (MRI) and genetic data allows researchers to utilize multimodal better understand the characteristics dementia Alzheimer's type (DAT). Objective: goal this study was develop analyze novel biomarkers that can help predict development progression DAT. Methods: We used feature selection ensemble learning classifier an image/genotype-based DAT score represents a subject's likelihood developing in...
Cancer-associated fibroblasts (CAFs) play a substantial role in promoting cancer cell motility, drug resistance, angiogenesis, and metastasis; therefore, extensive research has been conducted to determine their mode of activation. We aimed identify whether miRNA-200 (miR-200), widely recognized suppressor epithelial-mesenchymal transition, prevents CAFs from progression. Overexpression miR-200 prevented lung migration, invasion, tumorigenicity, metastasis. Additionally, suppressed the...
The visibility of retinal microvasculature in optical coherence tomography angiography (OCT-A) images is negatively affected by the small dimension capillaries, pulsatile blood flow, and motion artifacts. Serial acquisition time-averaging multiple OCT-A can enhance definition capillaries result repeatable consistent visualization. We demonstrate an automated method for registration averaging serially acquired images. Ten volumes from six normal control subjects were using our prototype...