A5022590189- Genetics, Aging, and Longevity in Model Organisms
- Obstructive Sleep Apnea Research
- Adipokines, Inflammation, and Metabolic Diseases
- Tracheal and airway disorders
- Regulation of Appetite and Obesity
- Corporate Finance and Governance
- Hearing Loss and Rehabilitation
- Adipose Tissue and Metabolism
- Patient Satisfaction in Healthcare
- Hemoglobinopathies and Related Disorders
- Craniofacial Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Cleft Lip and Palate Research
- Hearing, Cochlea, Tinnitus, Genetics
- Circadian rhythm and melatonin
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Photorefractive and Nonlinear Optics
- Eosinophilic Disorders and Syndromes
- Oral and Maxillofacial Pathology
- Pediatric Urology and Nephrology Studies
- Photoreceptor and optogenetics research
- Prostate Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Sleep and related disorders
University of British Columbia
2020-2024
University of Arizona
2019-2024
Washington University in St. Louis
2017-2024
New Jersey Institute of Technology
2024
University of Virginia Health System
2021-2024
Dartmouth–Hitchcock Medical Center
2024
Harvard University
2024
University of Illinois Chicago
2023
British Columbia Children's Hospital
2022-2023
Vancouver Coastal Health
2023
Studies on the relationship between regional fat and insulin resistance yield mixed results. Our objective was to determine whether distribution, independent of obesity, is associated with resistance.Subjects included 115 healthy, overweight/moderately obese adults body mass index (BMI) 25-36.9 kg/m(2) who met predetermined criteria for being resistant (IR) or sensitive (IS) based modified suppression test. Computerized tomography used quantify visceral adipose tissue (VAT), sc (SAT), thigh...
The aim was to evaluate the ability of liraglutide augment weight loss and improve insulin resistance, cardiovascular disease (CVD) risk factors, inflammation in a high-risk population for type 2 diabetes (T2DM) CVD.We randomized 68 older individuals (mean age, 58±8 years) with overweight/obesity prediabetes this double-blind study 1.8 mg versus placebo 14 weeks. All subjects were advised decrease calorie intake by 500 kcal/day. Peripheral resistance quantified measuring steady-state plasma...
Abstract Amyloid beta (Aβ) deposits in the retina of Alzheimer’s disease (AD) eye may provide a useful diagnostic biomarker for AD. This study focused on relationship Aβ with macroglia and microglia, as these glial cells are hypothesized to play important roles homeostasis clearance AD retina. Significantly higher load was found compared controls, specifically mid-peripheral region. showed significantly less immunoreactivity against fibrillary acidic protein (GFAP) glutamine synthetase (GS)...
Thailand has undergone dramatic social changes in the last two decades, yet little is known about factors related to sexual initiation among adolescents.A survey using audio computer-assisted self-interviewing method was conducted assess and demographic characteristics, substance use, behavior, knowledge of HIV STIs 1,725 vocational school students aged 15-21 living northern Thailand. Gender differences for these were evaluated chi-square Mann-Whitney U tests. Multivariate survival analysis...
Platelets from patients with myeloproliferative neoplasms (MPNs) exhibit a hyperreactive phenotype. Here, we found elevated P-selectin exposure and platelet-leukocyte aggregates indicating activation of platelets essential thrombocythemia (ET) patients. Single-cell RNA-seq analysis primary samples revealed significant enrichment transcripts related to platelet activation, mTOR, oxidative phosphorylation in ET patient platelets. These observations were validated via proteomic profiling....
Perioperative instillation of intravesical chemotherapy after bladder tumor resection is supported by level I evidence showing a 30% decrease in recurrence. However, studies administrative data sets show poor use practice.We prospectively evaluated the perioperative multipractice quality improvement collaborative. Cases were categorized as ideal for (1 or 2 papillary tumors, cTa/cT1 and completely resected) nonideal. The reasons not administering cases classified appropriate modifiable....
Cleft lip and/or palate affects approximately one in 700 live births. Optimal timing for repair of cleft has yet to be objectively validated. Earlier takes advantage a high degree plasticity within the nasal cartilage and maxilla. The authors present patients enrolled an early protocol facilitating effective nostril.American Society Anesthesiologists class I II with unilateral undergoing before 3 months age were over 5 years. Perioperative data, surgical anesthetic complications,...
OBJECTIVE Salsalate treatment has been shown to improve glucose homeostasis, but the mechanism remains unclear. The aim of this study was evaluate effect salsalate on insulin action, secretion, and clearance rate in nondiabetic individuals with resistance. RESEARCH DESIGN AND METHODS This a randomized (2:1), single-blind, placebo-controlled (3.5 g daily for 4 weeks) All had measurement tolerance (75-g oral test), steady-state plasma (SSPG; suppression secretion (graded-glucose infusion test)...
Conversion of mesenchymal stem cells into terminally differentiated adipocytes progresses sequentially through regulated transcriptional steps. While it is clear that the late phases adipocyte maturation are governed by nuclear receptor peroxisome proliferator-activated gamma (PPARγ), less known about control initial stages differentiation. To identify early regulators, we performed a small interfering RNA (siRNA) screen Forkhead-box genes in and show here for first time winged helix factor...
Prevalence of cardiovascular disease (CVD) is increased in patients with obstructive sleep apnea (OSA), possibly related to dyslipidemia these individuals. Insulin resistance also common OSA, but its contribution OSA unclear. The study's aim was define the relationships among abnormalities lipoprotein metabolism, clinical measures and insulin resistance. Cross-sectional study. severity defined by apnea-hypopnea index (AHI) during polysomnography. Hypoxia were expressed as minimum mean oxygen...
Matrix metalloproteinases (MMPs) play critical roles in cancer invasion and metastasis by digesting basement membrane extracellular matrix (ECM). Much attention has focused on the enzymatic activities of MMPs; however, regulatory mechanism MMP expression remains elusive. By employing bioinformatics analysis, we identified a potential p53 response element within MMP-14 promoter. Experimentally, found that can repress promoter activity, whereas deletion this abrogated effect. Furthermore,...
Over the last 3 years a shift at our institution has taken place in which patients who would have been offered nasoalveolar molding (NAM) as an adjunct to cleft lip repair (repair after months) instead undergone early (ECLR) (2-5 weeks of life) without NAM. This study sought examine financial and social impact transition away from NAM ECLR. The efficacy is limited by patient compliance rigorous treatment schedule requiring weekly visits for appliance adjustments. Nasoalveolar required...
Intercellular signaling mediated by evolutionarily conserved planar cell polarity (PCP) proteins aligns along the tissue plane and drives polarized behaviors during morphogenesis. Accumulating evidence indicates that vertebrate PCP pathway is regulated noncanonical, β-catenin-independent Wnt signaling; however, components mechanisms are incompletely understood. In mouse hearing organ, both noncanonical (ncWnt) required in developing auditory sensory epithelium to control cochlear duct...
Exploring evacuation spill information from the U.S. Coast Guard's National Response Center database, we examine how firms alter their green innovation activities and strategies in response to environmental spills occurring near headquarters. We find that, nearby spills, increase both input output. Increases managers' perceived risk compliance cost, part due public outrage reprobation, enhanced local regulations, as well human capital redeployment, are three plausible underlying economic...
Neural circuits coordinate with muscles and sensory feedback to generate motor behaviors appropriate an animal’s environment. In C. elegans, the mechanisms by which circuit generates undulations modulates them based on environment are largely unclear. We quantitatively analyzed elegans locomotion during free movement transient optogenetic muscle inhibition. Undulatory movements were highly asymmetrical respect duration of bending unbending each cycle. Phase response curves induced brief...