A5101653997- Cerebrospinal fluid and hydrocephalus
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Virus-based gene therapy research
- Alzheimer's disease research and treatments
- Neurological and metabolic disorders
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- S100 Proteins and Annexins
- Vestibular and auditory disorders
- Thyroid Cancer Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Mesenchymal stem cell research
- Amyotrophic Lateral Sclerosis Research
- Restless Legs Syndrome Research
Kyungpook National University
2016-2025
Kyungpook National University Hospital
2015-2024
Catholic University of Korea
2020-2023
Osong Medical Innovation Foundation
2023
Yeouido St. Mary's Hospital
2023
Hallym University Kangnam Sacred Heart Hospital
2018-2022
Neurology, Inc
2014-2022
Seoul St. Mary's Hospital
2020-2021
Hallym University Medical Center
2021
Jeju National University
2014-2020
Objective: Exosomes are nanovesicles that released from normal and tumor cells detectable in cell culture supernatant human biological fluids.Although previous studies have explored exosomes cancer cells, little is understood regarding the functions of by cells.Natural killer (NK) display rapid immunity to metastatic or hematological malignancies, efforts been undertaken clinically exploit antitumor properties NK cells.However, characteristics derived remain unknown.In this study, we...
Tinnitus-the perception of sound in the absence an actual external sound-represents a symptom underlying condition rather than single disease. Several theories have been proposed to explain mechanisms tinnitus. Tinnitus generators are theoretically located auditory pathway, and such various occurring peripheral system explained terms spontaneous otoacoustic emissions, edge theory, discordant theory. Those present central dorsal cochlear nucleus, plasticity crosstalk somatosensory system,...
Exosomes derived from mesenchymal stem cells (MSCs) have been evaluated for their potential to be used as drug delivery vehicles. Synthetically personalized exosome mimetics (EMs) could the alternative vesicles delivery. In this study, we aimed isolate EMs human MSCs. Cells were mixed with paclitaxel (PTX) and PTX-loaded (PTX-MSC-EMs) isolated anticancer effects against breast cancer. bone marrow-derived MSCs (4 × 106 cells/mL) or without PTX at different concentrations in phosphate-buffered...
Abstract Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show regulates white and brown adipose tissue function. Pharmacological inhibition of synthesis leads to lipogenesis epididymal (WAT), induction browning inguinal WAT activation adaptive thermogenesis (BAT). Mice with inducible Tph1 KO tissues exhibit a similar phenotype as mice which inhibited...
Abstract Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in presence or absence treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). addition, tested efficacy MSC-EV on hair an animal model. increased DP proliferation elevated levels Bcl-2, phosphorylated Akt ERK. addition; treated MSC-EVs displayed secretion VEGF IGF-1. Intradermal injection into C57BL/6 mice...
Abstract Lipocalin‐2 (LCN2) has diverse functions in multiple pathophysiological conditions; however, its pathogenic role vascular dementia (VaD) is unknown. Here, we investigated the of LCN2 VaD using rodent models global cerebral ischemia and hypoperfusion with cognitive impairment neuroinflammation. Mice subjected to transient bilateral common carotid artery occlusion (tBCCAo) for 50 min showed neuronal death gliosis hippocampus at 7 days post‐tBCCAo. expression was observed predominantly...
In vivo biodistribution and fate of extracellular vesicles (EVs) are still largely unknown require reliable in tracking techniques. this study, bioluminescence imaging (BLI) using Renilla luciferase (Rluc) was developed applied to monitoring EVs derived from thyroid cancer (CAL-62 cells) breast (MDA-MB-231) nude mice after intravenous administration compared with a dye-based labeling method for EV CAL-62 cells. The were successfully labeled Rluc visualized by BLI mice. distribution the EVs,...
Lipocalin-2 (LCN2) is a member of the highly heterogeneous secretory protein family lipocalins and increases in its levels can contribute to neurodegeneration adult brain. However, there are no reports on role LCN2 Parkinson's disease (PD). Here, we report for first time that expression increased substantia nigra (SN) patients with PD. In mouse brains, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment neurotoxin model PD significantly upregulated expression, mainly reactive...
Diagnosing and treating dementia, including mild cognitive impairment (MCI), is challenging due to diverse disease types overlapping symptoms. Early MCI detection vital as it can precede yet distinguishing from later stage dementia intricate subtle The primary objective of this study adopt a complex network perspective unravel the underlying pathophysiological mechanisms dementia-related disorders. Leveraging extensive availability electroencephalogram (EEG) data, our focuses on meticulous...
CXCR4, the stromal cell-derived factor-1 receptor, plays an important role in migration of hematopoietic progenitor/stem cells to injured and inflamed areas. Noninvasive cell tracking methods could be useful for monitoring fate. Therefore, this study, we evaluated efficacy intravenous infusion genetically engineered mesenchymal stem (MSCs) overexpressing CXC chemokine receptor 4 (CXCR4) home tumor, by optical imaging. We constructed a retroviral vector containing CXCR with dual reporter...
Hair loss is a common medical problem affecting both males and females. Dermal papilla (DP) cells are the ultimate reservoir of with potential hair regeneration in patients. Here, we analyzed role macrophage-derived Wnts (3a 7b) macrophage extracellular vesicles (MAC-EVs) promoting growth. We studied proliferation, migration, expression growth factors human-DP presence or absence MAC-EVs. Additionally, tested effect MAC-EV treatment on mouse model human follicles. Data from western blot flow...
Abstract Mesenchymal stem cells (MSCs) can be used as a therapeutic armor for cancer. Extracellular vesicles (EVs) from MSCs have been evaluated anticancer effects. In vivo targeting of EVs to the tumor is an essential requirement successful therapy. Therefore, non-invasive methods monitoring in animal models are crucial developing EV-based cancer therapies. The present study develop bioluminescent using Renilla luciferase (Rluc)-expressing MSCs. MSC/Rluc (EV-MSC/Rluc) were visualized murine...
Oligomeric amyloid-ß is a major toxic species associated with Alzheimer's disease pathogenesis. Methods used to measure oligomeric amyloid-β in the blood have increased number recent years. The Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) specific method oligomerization tendencies blood. objective of this study was determine association between plasma and structural changes brain.We studied 162 subjects composed 92 community-based normal healthy subjects, 17 subjective cognitive...
Variants in the APOE gene region may explain ethnic differences association of Alzheimer’s disease (AD) with ε4. Ethnic allele frequencies for three SNPs (single nucleotide polymorphisms) were identified and tested 19,398 East Asians (EastA), including Koreans Japanese, 15,836 European ancestry (EuroA) individuals, 4985 African Americans, brain imaging measures cortical atrophy sub-samples EuroAs. Among ε4/ε4 AD risk increased substantially a dose-dependent manner number promoter SNP...
The metabolism of glutamine and glucose is recognized as a promising therapeutic target for the treatment cancer; however, targeted molecules that mediate in cancer cells have not been addressed. Here, we show restricting supply hepatoma cells, including HepG2 Hep3B markedly increased expression retinoic acid‐related orphan receptor alpha (RORα). Up‐regulation RORα glutamine‐deficient resulted from an increase level cellular reactive oxygen species nicotinamide adenine dinucleotide...