A5103234596- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Brain Tumor Detection and Classification
- RNA Research and Splicing
- Chronic Lymphocytic Leukemia Research
- Functional Brain Connectivity Studies
- Immunodeficiency and Autoimmune Disorders
- Cell Image Analysis Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA modifications and cancer
- Gene expression and cancer classification
- Neurological Disease Mechanisms and Treatments
- Biomedical Text Mining and Ontologies
- Cerebrospinal fluid and hydrocephalus
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Retinal Imaging and Analysis
- Metabolomics and Mass Spectrometry Studies
- Spectroscopy and Chemometric Analyses
- Acute Myocardial Infarction Research
- Anatomy and Medical Technology
- Genomics and Chromatin Dynamics
- Surgical Simulation and Training
- Advanced Proteomics Techniques and Applications
- Visual perception and processing mechanisms
Sungkyunkwan University
2018-2024
Samsung Medical Center
2017-2024
Korea Advanced Institute of Science and Technology
2023
Seoul National University Hospital
2023
Samsung (South Korea)
2023
Harvard University
2004-2007
Dana-Farber Cancer Institute
2004-2007
Harvard University Press
2005
Loss of heterozygosity (LOH) chromosomal regions bearing tumor suppressors is a key event in the evolution epithelial and mesenchymal tumors. Identification these usually relies on genotyping counterpart normal DNA noting where heterozygous alleles become homozygous tumor. However, paired samples for tumors cell lines are often not available. With advent oligonucleotide arrays that simultaneously assay thousands single-nucleotide polymorphism (SNP) markers, can now be done at high enough...
Abstract BACKGROUND The local and systemic effects of bacillus Calmette–Guerin (BCG) have been known for decades. To investigate the adjuvant effect BCG on resected American Joint Committee Cancer (AJCC) Stage I–III melanoma, Eastern Cooperative Oncology Group conducted a large trial to study use alone or combination dacarbazine between 1974 1978. METHODS A total 734 patients were randomized 4 clinical groups consolidated into 2 cohorts. Cohort I compared with observation II dacarbazine....
Abstract Previous studies on Alzheimer’s disease-type cognitive impairment (ADCI) and subcortical vascular (SVCI) has rarely explored spatiotemporal heterogeneity. This study aims to identify distinct cortical atrophy patterns in ADCI SVCI. 1,338 participants (713 ADCI, 208 SVCI, 417 cognitively unimpaired elders) underwent brain magnetic resonance imaging (MRI), amyloid positron emission tomography, neuropsychological tests. Using MRI, this measures thickness five regions (medial temporal,...
We aimed to determine whether lobar cerebellar microbleeds or concomitant and deep microbleeds, in the presence of cerebral attribute underlying advanced amyloid angiopathy pathology hypertensive arteriopathy.We categorized 71 patients with suspected markers (regardless microbleeds) into 4 groups according microbleed distribution: L (strictly cerebral, n=33), L/LCbll strictly n=13), L/Cbll/D (lobar, cerebellar, n=17), L/D (lobar deep, n=8). additionally 2 dentate nucleus involvement: (n=16)...
We aimed to investigate the association between glycemic variability (GV) and neuroimaging markers of white matter hyperintensities (WMH), beta-amyloid (Aβ), brain atrophy, cognitive impairment.
Abstract We developed machine learning (ML) algorithms to predict abnormal tau accumulation among patients with prodromal AD. recruited 64 AD using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Supervised ML approaches based on random forest (RF) and a gradient boosting (GBM) were used. The GBM resulted in an AUC of 0.61 (95% confidence interval [CI] 0.579–0.647) clinical data (age, sex, years education) higher 0.817 CI 0.804–0.830) neuropsychological data. highest was 0.86...
Background: Age at onset was suggested as one possible risk factor for motor dysfunction in Alzheimer’s disease (AD). Objective: We investigated the association of symptoms with cognition or neurodegeneration patients AD, and whether this differs by age onset. Methods: included 113 amyloid positive AD divided them into early-onset (EOAD) late-onset (LOAD), who underwent Unified Parkinson’s Disease Rating Scale (UPDRS)-Part III (=UPDRS) scoring, Mini-Mental State Examination (MMSE)/Clinical...
Abstract Motivation: Analysis of high-throughput proteomic/genomic data, in particular, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) data and microarray has led to a multitude techniques aimed at identifying potential biomarkers. Most the statistical for comparing two groups are based on qualitative measures such as P-value. A quantitative way interval estimation contrasts is more appealing. Results: We have devised simultaneous confidence...
Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) commonly coexist.We aimed to characterize an overlapping syndrome of AD NPH that presents with gait disturbance, ventriculomegaly on magnetic resonance imaging, significant amyloid deposition positron emission tomography (PET).Of 114 patients who underwent cerebrospinal fluid (CSF) drainage for a possible diagnosis between 2015 2020 in Samsung Medical Center, we identified 24 (21.1%) the PET, which referred as hydrocephalic...
Background Although the standardized uptake value ratio (SUVR) method is objective and simple, cut-off optimization using global SUVR values may not reflect focal increased in cerebrum. The present study investigated clinical neuroimaging characteristics according to focally β-amyloid (Aβ) Aβ status. Methods We recruited 968 participants with cognitive continuum. All underwent neuropsychological tests 498 18 F-florbetaben (FBB) amyloid positron emission tomography (PET) 470 F-flutemetamol...
In the subsection ''Initial probabilities'' of Results section, first sentence was incorrect and should say: These probabilities, denoted by P 0 (RET) (LOSS) ¼ 1 À (RET), specify probabilities RET LOSS for pterminal marker on a chromosome.The second line Equation incorrect.The correct equation is:and PðLOSSjRETÞ h Á
The aim of this study was to evaluate the association education and tau burden in mild cognitive impairment(MCI) patients with suspected non-Alzheimer pathology(SNAP). We recruited 56 aMCI who underwent MRI, [18F]-florbetaben PET [18F]THK-5351-PET. Among them, 25 turned out be amyloid negative, measured by PET. Presence neurodegeneration assessed hippocampal atrophy MRI. 16 were SNAP. used year as a proxy reserve. Tau using [18F]THK-5351-PET for all at Samsung or Asan Medical Center....
The aim of this study was to evaluate the association education and tau burden in patients with clinical probable Alzheimer's disease (AD). We recruited 26 AD patients. used year as a proxy cognitive reserve. amyloid positivity assessed by [18F]-florbetaben PET. Tau using [18F]THK-5351-PET for all at Samsung or Asan Medical Center. Cerebellar gray matter reference region we measured regional standardized uptake value ratio (SUVR). freeSurfer-derived ROIs. In logistic regression, not...
Alzheimer's disease (AD) and frontotemporal dementia (FTD) clinical syndromes are the most common causes of degenerative dementia. FTD include a behavioral variant (bvFTD) two subtypes primary progressive aphasia (PPA): semantic (svPPA) non-fluent/agrammatic (nfvPPA). Previous studies have shown that patients with these dementias demonstrate characteristic patterns cortical atrophy at group level. In this study, we first aimed to classify diagnosed (AD FTD) cognitively normal subjects using...
Amyloid imaging has become a clinically important diagnostic tool of Alzheimer's disease and related disorders. In many recent studies using amyloid PET, the images were classified as normal or abnormal based on their standard uptake value ratios(SUVRs). However, image processing pipelines to obtain SUVR differ among research centers are not readily accessible in clinical practice. Therefore, reading PET setting largely depends visual assessment. this preliminary study, we evaluated whether...
Amyloid imaging has become a clinically important diagnostic tool of Alzheimer's disease and related disorders. In many recent studies using amyloid PET, the images were classified as normal or abnormal based on their standard uptake value ratios(SUVRs). However, image processing pipelines to obtain SUVR differ among research centers are not readily accessible in clinical practice. Therefore, reading PET setting largely depends visual assessment. this preliminary study, we evaluated whether...
Alzheimer's disease (AD) and frontotemporal dementia (FTD) clinical syndromes are the most common causes of degenerative dementia. FTD include a behavioral variant (bvFTD) two subtypes primary progressive aphasia (PPA): semantic (svPPA) non-fluent/agrammatic (nfvPPA). Previous studies have shown that patients with these dementias demonstrate characteristic patterns cortical atrophy at group level. In this study, we first aimed to classify diagnosed (AD FTD) cognitively normal subjects using...