A5022350068- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Neurobiology of Language and Bilingualism
- Spatial Neglect and Hemispheric Dysfunction
- Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and genetic disorders
- Mesenchymal stem cell research
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Health, Environment, Cognitive Aging
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Health and Wellbeing Research
- Nutritional Studies and Diet
- Cerebrospinal fluid and hydrocephalus
- Amyotrophic Lateral Sclerosis Research
- Diet and metabolism studies
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Dr Youth Clinic
2023-2025
Convergence
2023-2025
Evidence Based Research (United States)
2025
Samsung (South Korea)
2012-2023
Samsung (United Kingdom)
2016-2023
Seoul National University Hospital
2023
Korea University
2016-2021
Hallym University
2016-2021
The Montreal Cognitive Assessment (MoCA) is a brief cognitive screening tool with high sensitivity for patients mild impairment (MCI). authors examined the validity and reliability of Korean version MoCA (MoCA-K) in elderly outpatients. MoCA-K, Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR) scale, neuropsychological batteries were administered to 196 persons (mild Alzheimer's disease [AD] = 44, MCI 37, normal controls [NC] 115). MoCA-K scores highly correlated those...
The Seoul Neuropsychological Screening Battery (SNSB) is one of the standardized neuropsychological test batteries widely used in Korea.However, it may be a bit too lengthy for patients with decreased attention span; and does not provide score global cognitive function (GCF), which useful monitoring longitudinally.We sought to validate dementia version SNSB (SNSB-D) that was shorter than original contained only scorable tests GCF 300.We administered SNSB-D mild impairment (MCI) (n=43)...
Noninvasive parcellation of the human cerebral cortex is an important goal for understanding and examining brain functions. Recently, patterns anatomical connections using diffusion tensor imaging (DTI) have been used to parcellate regions. Here, we present a noninvasive approach that uses "functional fingerprints" obtained by correlation measures on resting state functional magnetic resonance (fMRI) data In other terms, regions are parcellated based similarity their connection--as reflected...
In Alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe throughout cortex, ensuing cognitive decline and dementia. Similarly, circumscribed patterns of pathological have been observed in normal ageing small vessel suggesting a spatially ordered distribution across different diseases. vitro findings suggest that may spread 'prion-like' neuronal connections an activity-dependent manner. Supporting this notion, functional brain networks show spatial...
Perivascular spaces that are visible on magnetic resonance imaging (MRI) a neuroimaging marker of cerebral small vessel disease. Their location may relate to the type underlying pathology: those in white matter centrum semi-ovale have been associated with amyloid angiopathy, while basal ganglia deep perforating artery arteriolosclerosis. As angiopathy is an almost invariable pathological finding Alzheimer's disease, we hypothesized MRI-visible perivascular would be clinical diagnosis whereas...
Because the signs associated with dementia due to Alzheimer disease (AD) can be heterogeneous, goal of this study was use 3-dimensional MRI examine various patterns cortical atrophy that AD type, and investigate whether categorized into anatomical subtypes.
Abstract Introduction We conducted a phase 1 clinical trial in nine patients with mild‐to‐moderate Alzheimer's disease to evaluate the safety and dose‐limiting toxicity of stereotactic brain injection human umbilical cord blood–derived mesenchymal stem cells (hUCB‐MSCs). Methods The low‐ (n = 3) high‐dose 6) groups received total 3.0 × 10 6 cells/60 μL 6.0 μL, respectively, into bilateral hippocampi right precuneus. Results No patient showed serious adverse events including fever during...
Patients with dementia develop dysphagia some time during the clinical course of their disease. The aim this study was to compare swallowing functions 2 most common types dementia: Alzheimer disease (AD) and vascular (VaD). Videofluoroscopic studies patient groups were analyzed according various oral, pharyngeal, laryngeal variables swallowing. results indicate that there are different patterns disorders. AD patients significantly more impaired in "oral transit delay over 5 seconds" liquids...
Cerebral microbleeds (CMBs) are a neuroimaging marker of small vessel disease (SVD) with relevance for understanding mechanisms in cerebrovascular disease, cognitive impairment, and normal aging. It is hypothesized that lobar CMBs due to cerebral amyloid angiopathy (CAA) deep subcortical ischemic SVD. We tested this hypothesis using structural magnetic resonance imaging (MRI) markers SVD vivo patients impairment.We included 226 patients: 89 Alzheimer disease-related impairment (ADCI) 137...
Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid and cognitive manifestation persons without dementia important for a better understanding of course AD design prevention trials.To investigate whether associated with functioning dementia.This cross-sectional study included 2908 participants normal cognition 4133 mild impairment (MCI) from 53 studies multicenter Amyloid Biomarker Study. Normal was defined as having no...
Our previous studies demonstrated that transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the hippocampus a transgenic mouse model Alzheimer's disease (AD) reduced amyloid-β (Aβ) plaques and enhanced cognitive function through paracrine action. Due to limited life span hUCB-MSCs after their transplantation, extension hUCB-MSC efficacy was essential for AD treatment. In this study, we show repeated cisterna magna injections activated endogenous...
Cerebrovascular disease (CVD) and Alzheimer are significant causes of cognitive impairment in the elderly. However, few studies have evaluated relationship between CVD β-amyloid burden living humans or their synergistic effects on cognition. Thus, there is a need for better understanding mild (MCI) before clinical deterioration begins.
Brain age estimation from anatomical features has been attracting more attention in recent years. This interest brain is motivated by the importance of biological prediction health informatics, with an application to early neurocognitive disorders. It well-known that normal aging follows a specific pattern, which enables researchers and practitioners predict human's its degeneration. In this paper, we model predicted cortical thickness data gathered large cohort images. We collected 2,911...
In Alzheimer's continuum (a comprehensive of preclinical disease [AD], mild cognitive impairment [MCI] due to AD, and AD dementia), dysfunctions are often related cortical atrophy in specific brain regions. The purpose this study was investigate the association between anatomical pattern neuropsychological deficits.A total 249 participants with (125 dementia, 103 MCI 21 AD) who were confirmed be positive for amyloid deposits collected from memory disorder clinic department neurology at...
Alzheimer's disease is the most common cause of dementia, and currently, there no disease-modifying treatment. Favorable functional outcomes reduction amyloid levels were observed following transplantation mesenchymal stem cells (MSCs) in animal studies.We conducted a phase I clinical trial nine patients with mild-to-moderate dementia to evaluate safety dose-limiting toxicity three repeated intracerebroventricular injections human umbilical cord blood-derived MSCs (hUCB-MSCs).We recruited...
Individual differences in working memory relate to performance general cognitive ability. The neural bases of such individual differences, however, remain poorly understood. Here, using a data-driven technique known as connectome-based predictive modeling, we built models predict from whole-brain functional connectivity patterns. Using n-back or rest data the Human Connectome Project, significantly predicted novel individuals' 2-back accuracy. Model predictions also correlated with measures...
In a clinical setting, an individual subject classification model rather than group analysis would be more informative. Specifically, the subtlety of cortical atrophy in some frontotemporal dementia (FTD) patients and overlapping patterns among three FTD syndromes including behavioral variant (bvFTD), non-fluent/agrammatic primary progressive aphasia (nfvPPA), semantic PPA (svPPA) give rise to need for models at level. this study, we aimed classify each into one diagnostic categories...