A5017084934- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Visual perception and processing mechanisms
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Neuroscience and Music Perception
- Cerebrovascular and genetic disorders
- Neonatal and fetal brain pathology
- Multisensory perception and integration
- Face Recognition and Perception
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Ginkgo biloba and Cashew Applications
Yale University
2003-2025
Massachusetts General Hospital
2021-2024
Harvard University
2016-2024
University of New Haven
2021-2023
Hanyang University
2013-2019
Samsung Medical Center
2015-2016
University of Ulsan
2016
Asan Medical Center
2016
Ulsan College
2016
Montreal Neurological Institute and Hospital
2016
Abstract Introduction We conducted a phase 1 clinical trial in nine patients with mild‐to‐moderate Alzheimer's disease to evaluate the safety and dose‐limiting toxicity of stereotactic brain injection human umbilical cord blood–derived mesenchymal stem cells (hUCB‐MSCs). Methods The low‐ (n = 3) high‐dose 6) groups received total 3.0 × 10 6 cells/60 μL 6.0 μL, respectively, into bilateral hippocampi right precuneus. Results No patient showed serious adverse events including fever during...
The full neural circuits of conscious perception remain unknown. Using a visual task, we directly recorded subcortical thalamic awareness potential (TAP). We also developed unique paradigm to classify perceived versus not stimuli using eye measurements remove confounding signals related reporting on experiences. fMRI, discovered three major brain networks driving independent report: first, increases in signal detection regions visual, fusiform cortex, and frontal fields; arousal/salience...
Abstract Study Objective Sleep spindles are present from birth and reflect cognitive functions across the lifespan, but normative values for this biomarker development lacking. This study aims to establish spindle features over development. Methods All available normal 19-channel electroencephalograms developmentally children between February 2002 June 2021 in MGH EEG lab were analyzed. Approximately, 20 000 hand-marked train validate an automated detector ages. Normative rate, duration,...
The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted alters cortical thickness in the brains elderly participants. A controlled trial conducted with 85 volunteers without impairment who were 60 years old or older. Participants first randomized into two groups. One group consisted 48 participants would receive training and 37 not training. randomly divided groups, 24 received traditional for both groups daily 90-min-session, five days a...
We tested our hypothesis that the white matter network might mediate effect of amyloid and small vessel disease (SVD) on cortical thickness and/or cognition.We prospectively recruited 232 patients with cognitive impairment. Amyloid was assessed using Pittsburgh compound B-PET. SVD quantified as hyperintensity volume lacune number. The regional connectivity measured nodal efficiency by applying graph theoretical analysis to diffusion tensor imaging data. performed neuropsychological tests.SVD...
See Cohen (doi:10.1093/aww183) for a scientific commentary on this article. Amyloid-β and cerebral small vessel disease are the two major causes of cognitive impairment in elderly. However, underlying mechanisms responsible precisely how amyloid-β affect remain unclear. We investigated effects lacunes downstream imaging markers including structural network cortical thickness, further analysing their relative impact trajectories. prospectively recruited pool 117 mild patients (45 amnestic...
Background:Recent evidence suggests that combining individual imaging markers of cerebral small vessel disease (SVD) may more accurately reflect its overall burden and better correlate with clinical measures. Objective:We wished to establish the relevance total SVD score in a memory clinic population by investigating association cognitive performance, cortical atrophy, structural network measures, after adjusting for amyloid-β burden. Methods:We included 243 patients amnestic mild impairment...
Abstract This study aimed to investigate the cortical neural correlates of dementia conversion in Parkinson's disease with mild cognitive impairment (PD‐MCI). We classified 112 patients drug‐naïve early stage PD meeting criteria for PD‐MCI into either (PDD) converters ( n = 34) or nonconverters 78), depending on whether they developed within 4 years diagnosis. Cortical thickness analyses were performed 34 PDD and matched nonconverters. Additionally, a linear discriminant analysis was...
Although recent work has made headway in understanding the neural temporospatial dynamics of conscious perception, much that focused on visual paradigms. To determine whether there are shared mechanisms for perceptual consciousness across sensory modalities, here we test within auditory domain. Participants completed an threshold task while undergoing intracranial electroencephalography. Recordings from >2,800 grey matter electrodes were analyzed broadband gamma power (a range which reflects...
Alzheimer's disease dementia (ADD) and subcortical vascular (SVaD) both show cortical thinning white matter (WM) microstructural changes. We evaluated different patterns of correlation between gray (GM) WM changes in pure ADD, SVaD, mixed dementia. enrolled 40 Pittsburgh compound B (PiB) positive ADD patients without hyperintensities (pure ADD), 32 PiB negative SVaD SVaD), 23 (mixed dementia), 56 normal controls. integrity was quantified using fractional anisotropy (FA), axial diffusivity...
During visual conscious perception, the earliest responses linked to signal detection are little known. The current study aims reveal cortical neural activity changes in stages of perception using recordings from intracranial electrodes. Epilepsy patients (N=158) were recruited a multi-center collaboration and completed word recall task. Broadband gamma (40-115Hz) was extracted with band-pass filter power calculated across subjects on common brain surface. Our results show early increases...
Background and purpose Recent studies have demonstrated that Alzheimer's disease ( AD ) subcortical vascular dementia SV aD) white matter WM microstructural changes. However, previous on aD rarely eliminated the confounding effects of patients with mixed cerebrovascular pathologies. Therefore, our aim was to evaluate divergent topography changes in pure aD. Methods Patients who were clinically diagnosed prospectively recruited. Forty Pittsburgh compound B (PiB) positive [PiB(+) ] without...
To clarify whether subtyping of amnestic and non-amnestic mild cognitive impairment (MCI) is clinically relevant in Parkinson's disease (PD) by analyzing patterns neuroimaging longitudinal changes.We performed comparative analyses cortical thickness, hippocampal volume, white matter integrity resting-state functional connectivity between the patients with de-novo PD MCI (PD-aMCI) (n = 50) (PD-naMCI) subtypes. Additionally, we assessed rate decline each domain over time dementia conversion...
There is growing evidence that the human brain a large scale complex network. The structural network reported to be disrupted in cognitively impaired patients. However, there have been few studies evaluating effects of amyloid and small ves
Previous studies have indicated that memory training may help older people improve cognition. However, evidence regarding who will benefit from such trainings has not been fully discovered yet. Understanding the clinical and neural inter-individual differences for predicting cognitive improvement is important maximizing efficacy of memory-training programs. The purpose this study was to find individual characteristics brain morphological predict after a multi-strategic based on metamemory...
Previous studies have introduced the concept of "SuperAgers," defined as older adults with youthful memory performance associated increased cortical thickness anterior cingulate cortex. Given that age-related structural brain changes are observed earlier in white matter (WM) than areas, we investigated whether WM integrity is different between SuperAgers (SA) and typical agers (TA) it superior well a healthy lifestyle. A total 35 SA 55 TA were recruited for this study. Further, 3.0-T...
Epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) is a challenging neurodevelopmental disease characterized by abundant epileptiform spikes during non-rapid eye movement (NREM) accompanied cognitive dysfunction. The mechanism of dysfunction unknown, but treatment high-dose diazepam may improve symptoms. Spike rate does not predict response, disrupt spindles. We hypothesized that patients EE-SWAS: (1) and spindles would be anti-correlated, (2) increase decrease spikes,...
Rolandic epilepsy (RE), the most common childhood focal syndrome, is characterized by a transient period of sleep-activated epileptiform activity in centrotemporal regions and variable cognitive deficits. Sleep spindles are prominent thalamocortical brain oscillations during sleep that have been mechanistically linked to sleep-dependent memory consolidation animal models healthy controls. decreased RE related epileptic encephalopathies. To further evaluate association between this...
Emerging evidence suggests that low serum 25-hydroxyvitamin D (25OHD) may induce cognitive decline and dementia, however, the pathophysiological mechanisms are poorly understood.We sought to determine relationship between vitamin deficiency neuronal integrity in cognitively impaired patients.One hundred nine patients with memory impairment were divided into quartiles according concentrations of 25OHD concentration, from lowest (L-25OHD) highest (H-25OHD). The diffusion tensor images L-25OHD...
Abstract Morphometric correlation networks of cortical thickness, surface area, and gray matter volume have statistically different structural topology. However, there is no report directly describing their patterns in view interregional covariance. Here, we examined the characteristics three morphometric using a Venn diagram concept across 314 normal subjects. We found that over 60% all nonoverlapping emerged with divergent unique patterns, while were 10% common edges ipsilateral homotopic...
<h3>Objective:</h3> To evaluate the differences between early-onset subcortical vascular cognitive impairment (EO-SVCI) and late-onset (LO-SVCI) with regard to pathologic burden, structural changes, function. <h3>Methods:</h3> We prospectively recruited 142 patients from a single referral center. Patients were divided into EO-SVCI (n = 30, age at onset <65 years) LO-SVCI 112, ≥65 groups. All underwent neuropsychological tests, 3T brain MRI, [<sup>11</sup>C] Pittsburgh compound B...
The authors examined the effects of arts education on cognition, behavior, and brain children. Twenty-nine nonclinical children participated in a 15-week program that was composed either creative movement or musical arts. Children completed Wisconsin Card Sorting Test, clinical scales, magnetic resonance imaging before after intervention. Following completion, performances Children’s Depression Inventory scores, conduct disorder scores were significantly improved. Furthermore, cortical...
Abstract Background Metamemory is the process of monitoring and controlling one's memory. Improving metamemory may reduce memory problem in old age. We hypothesized that training (MMT) would improve cognition older adults with subjective complaints change brain region related to metacognition. Method recruited randomized multi‐strategic 10 weekly 90‐min sessions, based on concept or usual care. Cognitive tests including Elderly Verbal Learning Test, Simple Rey Figure Digit Span, Spatial...